化合物简介
GW3965 is a potent, selective liver X receptor (LXR) agonist for hLXRα and hLXR. GW3965 has shown potent anti-inflammatory activity in both irritant and allergic contact models of dermatitis, requiring the participation of both LXRα and LXRβ.
基本信息
中文名称
GW3965
英文名称
GW3965
中文别名
3-[3-[[[2-氯-3-(三氟甲基)苯基]甲基](2,2-联苯基乙基)氨基]丙氧基]苯乙酸盐酸盐、3-[3-[[[2-氯-3-(三氟甲基)苯基]甲基](2,2-二苯基乙基)氨基]丙氧基]-苯乙酸、GW-3965
英文别名
UNII-6JI5YOG7RC、3-(3-(N-(2-Chloro-3-trifluoromethylbenzyl)(2,2-diphenylethyl)amino)propoxy)phenylacetic acid、(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-2,2-diphenylethyl-amino]-propoxy}-phenyl)-acetic acid、(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-acetic acid、2-(3-{3-[[2-chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino]propoxy}-phenyl)acetic acid、2-[3-[3-[[2-chloro-3-(trifluoromethyl)phenyl]methyl-(2,2-diphenylethyl)amino]propoxy]phenyl]acetic acid、2-(3-(3-((2-chloro-3-(trifluoromethyl)benzyl)(2,2-diphenylethyl)amino)propoxy)phenyl)acetic acid、3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-N-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid、2-{3-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2,2-diphenylethyl)amino)propoxy]phenyl}acetic acid
CAS号
405911-09-3
分子式
C33H31ClF3NO3
分子量
582.052
精确质量
581.194
PSA
49.77
LOGP
8.0891
编号系统
UNII
6JI5YOG7RC
物化性质
密度
1.261g/cm3
沸点
672.4ºC at 760mmHg
闪点
360.5ºC
合成路线
