化合物简介
Obeticholic acid (abbreviated to OCA), is a semi-synthetic bile acid analogue which has the chemical structure 6α-ethyl-chenodeoxycholic acid. It has also been known as INT-747. It is undergoing development as a pharmaceutical agent for several liver diseases and related disorders. Intercept Pharmaceuticals Inc. (NASDAQ symbol ICPT) hold the worldwide rights to develop OCA outside Japan and China, where it is licensed to Dainippon Sumitomo Pharma.
基本信息
中文名称
6-乙基鹅去氧胆酸
英文名称
6-Ethylchenodeoxycholic acid
中文别名
英文别名
6-ECDCA、INT-747、UNII-0462Z4S4OZ、6alpha-Ethyl-chenodeoxycholic acid、Obeticholic acid、1osv、CHC、(4R)-4-[(3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
CAS号
459789-99-2
分子式
C26H44O4
分子量
420.625
精确质量
420.324
PSA
77.76
LOGP
5.114
编号系统
MDL号
MFCD16621104
物化性质
密度
1.091
沸点
562.9ºC at 760 mmHg
闪点
308.3ºC
折射率
1.529
