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2-氨基-2-[2-(4-辛基苯基)乙基]-1,3-丙二醇

2-氨基-2-[2-(4-辛基苯基)乙基]-1,3-丙二醇

CAS号：162359-55-9

英文名：fingolimod

分子式

C19H33NO2

熔点

密度

1.016

分子量

307.471

沸点

479.5ºC at 760 mmHg

溶解度

信号词

危险品标志

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化合物简介

Fingolimod (INN, trade name Gilenya, Novartis) is an immunomodulating drug, mostly used for treating multiple sclerosis (MS). It has reduced the rate of relapses in relapsing-remitting multiple sclerosis by approximately one-half over a two-year period. Fingolimod is a sphingosine-1-phosphate receptor modulator, which sequesters lymphocytes in lymph nodes, preventing them from contributing to an autoimmune reaction.

基本信息

中文名称

2-氨基-2-[2-(4-辛基苯基)乙基]-1,3-丙二醇

英文名称

fingolimod

中文别名

英文别名

2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol、Fingolimod、UNII-3QN8BYN5QF

CAS号

162359-55-9

分子式

C19H33NO2

分子量

307.471

精确质量

307.251

PSA

66.48

LOGP

3.9046

编号系统

UNII

3QN8BYN5QF

物化性质

密度

1.016

沸点

479.5ºC at 760 mmHg

闪点

243.8ºC

合成路线

共找到5条合成路线 >

2-硝基去氨基芬戈莫德

2-硝基去氨基芬戈莫德

2-氨基-2-[2-(4-辛基苯基)乙基]-1,3-丙二醇

2-氨基-2-[2-(4-辛基苯基)乙基]-1,3-丙二醇

上游原料

共找到39个上游原料 >

tert-butyl (5-(4-octylphenethyl)-2-phenyl-1,3-dioxan-5-yl)carbamate

tert-butyl (5-(4-octylphenethyl)-2-phenyl-1,3-dioxan-5-yl)carbamate

(3-nitro-5-(4-octylphenyl)tetrahydrofuran-3-yl)-methanol

(3-nitro-5-(4-octylphenyl)tetrahydrofuran-3-yl)-methanol

diethyl 4-octanoylbenzylphosphonate

diethyl 4-octanoylbenzylphosphonate

1-(3-nitropropyl)-4-octylbenzene

1-(3-nitropropyl)-4-octylbenzene

(4-octanoylbenzyl)triphenylphosphonium bromide

(4-octanoylbenzyl)triphenylphosphonium bromide

2-硝基去氨基芬戈莫德

2-硝基去氨基芬戈莫德

下游产品

共找到5个下游商品 >

[2-amino-2-(hydroxymethyl)-4-(4-octylphenyl)butyl] dihydrogen phosphate

[2-amino-2-(hydroxymethyl)-4-(4-octylphenyl)butyl] dihydrogen phosphate

4,5-二氢-2-甲基-4-[2-(4-辛基苯基)乙基]-4-恶唑甲醇

4,5-二氢-2-甲基-4-[2-(4-辛基苯基)乙基]-4-恶唑甲醇

S) FTY720磷酸酯

S) FTY720磷酸酯

FTY 720 磷酸酯

FTY 720 磷酸酯

[1,1-双(羟基甲基)-3-(4-辛基苯基)丙基]氨基甲酸苯基甲酯

[1,1-双(羟基甲基)-3-(4-辛基苯基)丙基]氨基甲酸苯基甲酯

上游原料

tert-butyl (5-(4-octylphenethyl)-2-phenyl-1,3-dioxan-5-yl)carbamate (3-nitro-5-(4-octylphenyl)tetrahydrofuran-3-yl)-methanol diethyl 4-octanoylbenzylphosphonate 1-(3-nitropropyl)-4-octylbenzene (4-octanoylbenzyl)triphenylphosphonium bromide 2-硝基去氨基芬戈莫德 2-(乙酰氨基)-2-[2-(4-辛基苯基)-2-氧代乙基]-丙二酸 1,3-二乙酯 5-ethynyl-2,2-dimethyl-[1,3]dioxan-(N-tert-butyloxycarbonyl)-5-ylamine 4-硝基苄基三苯基溴蓊盐 tert-butyl (2,2-dimethyl-5-(4-(oct-1-en-1-yl)phenethyl)-1,3-dioxan-5-yl)carbamate 3-nitro-1-(4-octylphenyl)propane-1,2-diol 4-辛基苯甲醛 4-n-octyliodobenzene (4-octylphenyl)(oxiran-2-yl)methanol ethyl 2-amino-2-ethoxycarbonyl-4-(4-octylphenyl)butyrate tert-butyl 2,2-dimethyl-5-[(4-octylphenyl)ethynyl]-1,3-dioxan-5-ylcarbamate N-(1-羟基-2-(羟基甲基)-4-(4-辛基苯基)-2-丁基)乙酰胺 N-[2,2-二甲基-5-[2-(4-辛基苯基)乙基]-1,3-二氧六环-5-基]氨基甲酸叔丁酯乙酸-[2-(4-辛酰基苯基)]乙酯 4-氯苯甲醛乙酸-[2-(4-辛基苯基)]乙酯 3-nitro-1-(4-octylphenyl)propan-1-ol 2-bromo-1-(4-octylphenyl)ethanone 乙酸-[2-(4-辛酰基苯基)]乙酯二乙基2-乙酰胺基-2-(4-辛基苯乙基)丙二酸酯 tert-butyl (2,2-dimethyl-5-(4-nitrostyryl)-1,3-dioxan-5-yl)carbamate 1-(4-(bromomethyl)phenyl)octan-1-one tert-butyl 5-(4-aminophenethyl)-2,2-dimethyl-1,3-dioxan-5-ylcarbamate tert-butyl 2,2-dimethyl-5-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenethyl)-1,3-dioxan-5-ylcarbamate 2-乙酰胺基-2-(4-辛基苯乙基)丙烷-1,3-二基二乙酸酯乙酸-[2-(4-辛基苯基)]乙酯 1-苯基辛烷乙酸苯乙酯乙酸-[2-(4-辛基苯基)]乙醇 1-octylzinc(II) iodide 4-辛基苯乙醇甲磺酸酯辛酰氯 4-(2-碘代乙基)辛基苯

下游产品

[2-amino-2-(hydroxymethyl)-4-(4-octylphenyl)butyl] dihydrogen phosphate 4,5-二氢-2-甲基-4-[2-(4-辛基苯基)乙基]-4-恶唑甲醇 S) FTY720磷酸酯 FTY 720 磷酸酯 [1,1-双(羟基甲基)-3-(4-辛基苯基)丙基]氨基甲酸苯基甲酯