K-252a

K-252a

CAS号：99533-80-9

英文名：K-252a

分子式

C27H21N3O5

熔点

密度

1.67g/cm3

分子量

467.473

沸点

685.3ºC at 760mmHg

溶解度

信号词

Danger

危险品标志

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化合物简介

K252a is an alkaloid isolated from Nocardiopisis sp. soil fungi. This staurosporine analog is a highly potent cell permeable inhibitor of CaM kinase and phosphorylase kinase (IC50 = 1.8 and 1.7 nmol/L, respectively). At higher concentrations it is also an efficient inhibitor of serine/threonine protein kinases (IC50 of 10 to 30 nmol/L).

基本信息

中文名称

K-252a

英文名称

K-252a

中文别名

英文别名

K-252A,NOCARDIOPSIS SP、antibioticsf2370、PROTEIN KINASE INHIBITOR FROM NORCARDIOP SIS SP.、PROTEIN KINASE INHIBITOR K-252A、antibiotick252a、sf2370、K252a、PROTEIN KINASE INHIBITOR

CAS号

99533-80-9

分子式

C27H21N3O5

分子量

467.473

精确质量

467.148

PSA

94.72

LOGP

3.9839

编号系统

UNII

IV7H45AM5B

物化性质

密度

1.67g/cm3

沸点

685.3ºC at 760mmHg

闪点

368.2ºC

折射率

1.841

储存条件

-20ºC

安全信息

安全说明

S22; S24/25

危险品标志

Xi

危险性描述

H360D; H371

信号词

Danger

危险标志

GHS08

危险性防范说明

P201; P260; P308 + P311

合成路线

共找到2条合成路线 >

硫酸二甲酯

硫酸二甲酯

K-252B

K-252a

上游原料

共找到17个上游原料 >

重氮甲烷

(2S,3S,5R)-5-(7-oxo-6,7-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-12(13H)-yl)-2-((phenylselanyl)methyl)tetrahydrofuran-3-yl acetate

(2S,3S,5R)-5-(7-oxo-6,7-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-12(13H)-yl)-2-((phenylselanyl)methyl)tetrahydrofuran-3-yl acetate

13-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one

13-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one

(2R,3R)-3-Hydroxy-2,5-dimethoxy-2-methyl-tetrahydro-furan-3-carboxylic acid methyl ester

(2R,3R)-3-Hydroxy-2,5-dimethoxy-2-methyl-tetrahydro-furan-3-carboxylic acid methyl ester

13-((2R,4S,5S)-4-hydroxy-5-((phenylselanyl)methyl)tetrahydrofuran-2-yl)-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one

13-((2R,4S,5S)-4-hydroxy-5-((phenylselanyl)methyl)tetrahydrofuran-2-yl)-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one

6-N-(dimethoxybenzyl)-staurosporinone

6-N-(dimethoxybenzyl)-staurosporinone

下游产品

共找到2个下游商品 >

蛋白激酶仰制剂KT5823

蛋白激酶仰制剂KT5823

来他替尼

上游原料

重氮甲烷 (2S,3S,5R)-5-(7-oxo-6,7-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-12(13H)-yl)-2-((phenylselanyl)methyl)tetrahydrofuran-3-yl acetate 13-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one (2R,3R)-3-Hydroxy-2,5-dimethoxy-2-methyl-tetrahydro-furan-3-carboxylic acid methyl ester 13-((2R,4S,5S)-4-hydroxy-5-((phenylselanyl)methyl)tetrahydrofuran-2-yl)-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one 6-N-(dimethoxybenzyl)-staurosporinone (E)-(R)-2-Acetyl-2-hydroxy-undec-4-enoic acid methyl ester K-252B (5S,6S,8R)-6-hydroxy-5-methyl-5,6,7,8,14,15-hexahydro-13H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacen-13-one 硫酸二甲酯 (5S,6S,8R)-6-cyano-5-methyl-13-oxo-5,6,7,8,14,15-hexahydro-13H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacen-6-yl acetate (5S,6S,8R)-5-methyl-13-oxo-6,7,8,13,14,15-hexahydro-5H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacen-6-yl acetate 13-((2R,4S,5S)-4-hydroxy-5-(iodomethyl)tetrahydrofuran-2-yl)-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one (5R,6S,8R)-5-(iodomethyl)-13-oxo-6,7,8,13,14,15-hexahydro-5H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacen-6-yl acetate (5S,8R)-5-methyl-7,8,14,15-tetrahydro-5H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacene-6,13-dione (3S,5R)-2-methylene-5-(7-oxo-6,7-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-12(13H)-yl)tetrahydrofuran-3-yl acetate (2R,3S,5R)-5-(6,13-diacetyl-7-oxo-5,6,7,13-tetrahydro-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-12-yl)-2-(((4-methylbenzoyl)oxy)methyl)tetrahydrofuran-3-yl 4-methylbenzoate

下游产品

蛋白激酶仰制剂KT5823 来他替尼