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来普霉素B

来普霉素B

CAS号：87081-35-4

英文名：leptomycin B

分子式

C33H48O6

熔点

41-44ºC

密度

1.072 g/cm3

分子量

540.731

沸点

725.8ºC at 760 mmHg

溶解度

信号词

危险品标志

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化合物简介

Leptomycin B is a secondary metabolite produced by Streptomyces spp.

基本信息

中文名称

来普霉素B

英文名称

leptomycin B

中文别名

英文别名

antibioticcl1957a、2,10,12,16,18-nonadecapentaenoic acid、antibioticci940、7,9,11,15-hexamethyl-8-oxo--yl)-17-ethyl-6-hydroxy-5、LEPTOMYCIN B FROM STREPTOMYCES SP、Leptomycin B,(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-19-[(2S,3S)-3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoicacid

CAS号

87081-35-4

分子式

C33H48O6

分子量

540.731

精确质量

540.345

PSA

100.9

LOGP

6.7847

编号系统

UNII

Y031I2N1EO

物化性质

外观与性状

白色结晶固体

密度

1.072 g/cm3

沸点

725.8ºC at 760 mmHg

熔点

41-44ºC

闪点

224.7ºC

折射率

1.542

储存条件

-20ºC

安全信息

安全说明

7-16-24-33-45

危险类别码

R23/25

危险品运输编码

UN 1230 3

海关编码

2916190090

危险品标志

T; F

合成路线

(2R,3S)-1-(benzyloxy)-3-methylpent-4-yn-2-ol

(2R,3S)-1-(benzyloxy)-3-methylpent-4-yn-2-ol

来普霉素B

上游原料

共找到19个上游原料 >

(S)-3-((2S,3R,4R,5R,6S,E)-5-((tert-butyldimethylsilyl)oxy)-3-hydroxy-10-(methoxymethoxy)-2,4,6,8-tetramethyldec-8-enoyl)-4-isopropyloxazolidin-2-one

(S)-3-((2S,3R,4R,5R,6S,E)-5-((tert-butyldimethylsilyl)oxy)-3-hydroxy-10-(methoxymethoxy)-2,4,6,8-tetramethyldec-8-enoyl)-4-isopropyloxazolidin-2-one

(2S,3R,4S,E)-3-((tert-butyldimethylsilyl)oxy)-8-(methoxymethoxy)-2,4,6-trimethyloct-6-enal

(2S,3R,4S,E)-3-((tert-butyldimethylsilyl)oxy)-8-(methoxymethoxy)-2,4,6-trimethyloct-6-enal

(2E,4R,5S,6R,7R,8S,10E)-1-bromo-7,12-bis((tert-butyldimethylsilyl)oxy)-2,4,6,8,10-pentamethyldodeca-2,10-dien-5-ol

(2E,4R,5S,6R,7R,8S,10E)-1-bromo-7,12-bis((tert-butyldimethylsilyl)oxy)-2,4,6,8,10-pentamethyldodeca-2,10-dien-5-ol

(5S,6R)-6-((benzyloxy)methyl)-5-methyl-5,6-dihydro-2H-pyran-2-one

(5S,6R)-6-((benzyloxy)methyl)-5-methyl-5,6-dihydro-2H-pyran-2-one

(2S,3S)-2-((R,1E,3Z)-3-ethyl-7-((4-methoxybenzyl)oxy)-5-methylhepta-1,3-dien-1-yl)-6-isopropoxy-3-methyl-3,6-dihydro-2H-pyran

(2S,3S)-2-((R,1E,3Z)-3-ethyl-7-((4-methoxybenzyl)oxy)-5-methylhepta-1,3-dien-1-yl)-6-isopropoxy-3-methyl-3,6-dihydro-2H-pyran

(2R,3S)-2-Benzyloxymethyl-6-isopropoxy-3-methyl-3,6-dihydro-2H-pyran

(2R,3S)-2-Benzyloxymethyl-6-isopropoxy-3-methyl-3,6-dihydro-2H-pyran

上游原料

(S)-3-((2S,3R,4R,5R,6S,E)-5-((tert-butyldimethylsilyl)oxy)-3-hydroxy-10-(methoxymethoxy)-2,4,6,8-tetramethyldec-8-enoyl)-4-isopropyloxazolidin-2-one (2S,3R,4S,E)-3-((tert-butyldimethylsilyl)oxy)-8-(methoxymethoxy)-2,4,6-trimethyloct-6-enal (2E,4R,5S,6R,7R,8S,10E)-1-bromo-7,12-bis((tert-butyldimethylsilyl)oxy)-2,4,6,8,10-pentamethyldodeca-2,10-dien-5-ol (5S,6R)-6-((benzyloxy)methyl)-5-methyl-5,6-dihydro-2H-pyran-2-one (2S,3S)-2-((R,1E,3Z)-3-ethyl-7-((4-methoxybenzyl)oxy)-5-methylhepta-1,3-dien-1-yl)-6-isopropoxy-3-methyl-3,6-dihydro-2H-pyran (2R,3S)-2-Benzyloxymethyl-6-isopropoxy-3-methyl-3,6-dihydro-2H-pyran (S)-4-isopropyl-3-((S,E)-6-(methoxymethoxy)-2,4-dimethylhex-4-enoyl)oxazolidin-2-one (5S,6S)-6-[(1E,3Z)-(R)-3-Ethyl-7-(4-methoxy-benzyloxy)-5-methyl-hepta-1,3-dienyl]-5-methyl-5,6-dihydro-pyran-2-one (5S,6S)-6-((1E,3Z,5R,7E,9E,11R,12S,13R,14R,15S,17E)-14,19-bis((tert-butyldimethylsilyl)oxy)-3-ethyl-12-hydroxy-5,9,11,13,15,17-hexamethylnonadeca-1,3,7,9,17-pentaen-1-yl)-5-methyl-5,6-dihydro-2H-pyran-2-one (E)-(S)-6-Methoxymethoxy-2,4-dimethyl-hex-4-enal (S)-3-((2S,3R,4S,E)-3-hydroxy-8-(methoxymethoxy)-2,4,6-trimethyloct-6-enoyl)-4-isopropyloxazolidin-2-one (2E,10E)-(4R,5S,6R,7R,8S)-1-Bromo-7-(tert-butyl-dimethyl-silanyloxy)-12-methoxymethoxy-2,4,6,8,10-pentamethyl-dodeca-2,10-dien-5-ol (2R,3S)-1-(benzyloxy)-3-methylpent-4-yn-2-ol (4Z,6E)-(R)-5-Ethyl-3-methyl-7-((2S,3S)-3-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-hepta-4,6-dienal (5S,6S)-6-((1E,3Z)-(R)-3-Ethyl-7-hydroxy-5-methyl-hepta-1,3-dienyl)-5-methyl-5,6-dihydro-pyran-2-one (2E,4R,5S,6R,7R,8S,10E)-7-((tert-butyldimethylsilyl)oxy)-12-(methoxymethoxy)-2,4,6,8,10-pentamethyldodeca-2,10-diene-1,5-diol (2R,3S)-6-isopropoxy-3-methyl-3,6-dihydro-2H-pyran-2-carbaldehyde