化合物简介
Nicergoline (INN, marketed under the trade name Sermion) is an ergot derivative used to treat senile dementia and other disorders with vascular origins. It has been found to increase mental agility and enhance clarity and perception. It decreases vascular resistance and increases arterial blood flow in the brain, improving the utilization of oxygen and glucose by brain cells. It has similar vasoactive properties in other areas of the body, particularly the lungs.
基本信息
中文名称
尼麦角林
英文名称
Nicergoline
中文别名
[(8R,10S)-10-甲氧基-1,6-地甲基麦角林-8-基]甲基-5-溴吡啶-3-羧酸酯、5-溴吡啶-3-羧酸-[(8R,10S)-10-甲氧基-1,6-二甲基麦角林-8-基]甲酯、麦角溴烟酯
英文别名
Sermion、Memoq、Cergodum、mne、fi6714、nargoline、ergoline-8-methanol 10-methoxy-1,6-dimethyl-,8-(5-bromo-3-pyridinecarboxylate)、Ergobel、[(8R,10S)-10-Methoxy-1,6-dimethylergolin-8-yl]methyl 5-Bromopyridine-3-carboxylate、5-bromo-nicotinic acid 10-methoxy-1,6-dimethyl-ergolin-8-ylmethyl ester、nigergoline、Dilasenil、5-Bromopyridine-3-carboxylic Acid [(8R,10S)-10-Methoxy-1,6-dimethylergolin-8-yl]methyl Ester、TA 079、Ergotop
CAS号
27848-84-6
分子式
C24H26BrN3O3
分子量
484.386
精确质量
483.116
PSA
56.59
LOGP
3.8488
编号系统
UNII
JCV8365FWN
物化性质
密度
1.47 g/cm3
沸点
594.4ºC at 760 mmHg
闪点
313.3ºC
稳定性
Stable at normal temperatures and pressures.
储存条件
2-8ºC
蒸汽压
0mmHg at 25°C
安全信息
安全说明
S36
危险类别码
R22
危险品运输编码
UN 1544
危险类别
6.1(b)
包装等级
III
危险品标志
Xn
