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    ChemeGen ChemeGen AS2863619 free base 纯度:98% CAS:2241300-50-3 (5mg/瓶) C110120 2241300-50-3
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    ¥4130
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    敏感偏远地区(云南、新疆、西藏、内蒙古、青海、海南、宁夏)不支持交易
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    AS2863619 free base enables conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells for the treatment of various immunological diseases. AS2863619 free base is a potent, orally active cyclin-dependent kinase 8 (CDK8) and CDK19 inhibitor with IC50s of 0.61 nM and 4.28 nM, respectively. STAT5 activation enhanced by AS2863619 free base inhibition of CDK8/19, which consequently activates the Foxp3 gene.