百科

p-nitrobenzyl 2-<(3S,4R)-3-<(1R)-(tert-butyldimethylsiloxy)ethyl>-4-<<(2R)-N-p-nitrobenzyloxycarbonylpyrrolidin-2-yl>carbonylthio>-2-oxoazetidin-1-yl>-2-triphenylphosphoranylideneacetate

CAS号：105499-15-8

英文名：p-nitrobenzyl 2-<(3S,4R)-3-<(1R)-(tert-butyldimethylsiloxy)ethyl>-4-<<(2R)-N-p-nitrobenzyloxycarbonylpyrrolidin-2-yl>carbonylthio>-2-oxoazetidin-1-yl>-2-triphenylphosphoranylideneacetate

分子式：C51H55N4O11PSSi

分子量：991.127

合成路线

81225-41-4

(2S,5R,6S)-6-Bromo-6-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid methyl ester

105499-15-8

p-nitrobenzyl 2-<(3S,4R)-3-<(1R)-(tert-butyldimethylsiloxy)ethyl>-4-<<(2R)-N-p-nitrobenzyloxycarbonylpyrrolidin-2-yl>carbonylthio>-2-oxoazetidin-1-yl>-2-triphenylphosphoranylideneacetate

105458-95-5

(R)-Pyrrolidine-1,2-dicarboxylic acid 1-(4-nitro-benzyl) ester

105499-15-8

p-nitrobenzyl 2-<(3S,4R)-3-<(1R)-(tert-butyldimethylsiloxy)ethyl>-4-<<(2R)-N-p-nitrobenzyloxycarbonylpyrrolidin-2-yl>carbonylthio>-2-oxoazetidin-1-yl>-2-triphenylphosphoranylideneacetate

87596-66-5

(S)-2-{(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-1-[chloro-(4-nitro-benzyloxycarbonyl)-methyl]-4-oxo-azetidin-2-ylsulfanylcarbonyl}-pyrrolidine-1-carboxylic acid 4-nitro-benzyl ester

105499-15-8

p-nitrobenzyl 2-<(3S,4R)-3-<(1R)-(tert-butyldimethylsiloxy)ethyl>-4-<<(2R)-N-p-nitrobenzyloxycarbonylpyrrolidin-2-yl>carbonylthio>-2-oxoazetidin-1-yl>-2-triphenylphosphoranylideneacetate

87596-65-4

p-nitrobenzyl 2-<(3S,4R)-3-<(1R)-(tert-butyldimethylsiloxy)ethyl>-4-<<(2S)-N-p-nitrobenzyloxycarbonylpyrrolidin-2-yl>carbonylthio>-2-oxoazetidin-1-yl>-2-hydroxyacetate

105499-15-8

p-nitrobenzyl 2-<(3S,4R)-3-<(1R)-(tert-butyldimethylsiloxy)ethyl>-4-<<(2R)-N-p-nitrobenzyloxycarbonylpyrrolidin-2-yl>carbonylthio>-2-oxoazetidin-1-yl>-2-triphenylphosphoranylideneacetate

上游原料

(R)-Pyrrolidine-1,2-dicarboxylic acid 1-(4-nitro-benzyl) ester (2S,5R,6S)-6-Bromo-6-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid methyl ester (S)-2-{(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-1-[chloro-(4-nitro-benzyloxycarbonyl)-methyl]-4-oxo-azetidin-2-ylsulfanylcarbonyl}-pyrrolidine-1-carboxylic acid 4-nitro-benzyl ester p-nitrobenzyl 2-<(3S,4R)-3-<(1R)-(tert-butyldimethylsiloxy)ethyl>-4-<<(2S)-N-p-nitrobenzyloxycarbonylpyrrolidin-2-yl>carbonylthio>-2-oxoazetidin-1-yl>-2-hydroxyacetate

下游产品

p-nitrobenzyl (5R,6S)-6-<(1R)-(tert-butyldimethylsiloxy)ethyl>-2-<(2R)-N-p-nitrobenzyloxycarbonylpyrrolidin-2-yl>-2-penem-3-carboxylate (5R,6S)-6-<(1R)-hydroxyethyl>-2-<(2R)-pyrrolidin-2-yl>-2-penem-3-carboxylic acid