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乙基甲基(4S)-4-(2,3-二氯苯基)-2,6-二甲基-1,4-二氢-3,5-吡啶二羧酸酯

CAS号：105618-03-9

英文名：5-O-ethyl 3-O-methyl (4R)-4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

分子式

C18H19Cl2NO4

熔点

密度

1.277g/cm3

分子量

384.254

沸点

471.5ºC at 760mmHg

溶解度

信号词

危险品标志

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化合物简介

A dihydropyridine calcium channel blocker. Enantiomer S of Felodipine.

基本信息

中文名称

乙基甲基(4S)-4-(2,3-二氯苯基)-2,6-二甲基-1,4-二氢-3,5-吡啶二羧酸酯

英文名称

5-O-ethyl 3-O-methyl (4R)-4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

中文别名

英文别名

Lopac-F-9677

CAS号

105618-03-9

分子式

C18H19Cl2NO4

分子量

384.254

精确质量

383.069

PSA

64.63

LOGP

4.2931

编号系统

UNII

X2HM27A9QK

物化性质

密度

1.277g/cm3

沸点

471.5ºC at 760mmHg

闪点

239ºC

折射率

1.549

蒸汽压

4.62E-09mmHg at 25°C

合成路线

1352187-22-4

3-ethyl 5-((R)-1-hydroxy-3-(phenylsulfonyl)propan-2-yl) (R)-4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

74-88-4

甲基碘

105618-03-9

乙基甲基(4S)-4-(2,3-二氯苯基)-2,6-二甲基-1,4-二氢-3,5-吡啶二羧酸酯

上游原料

(S)-4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-5-pivaloyloxymethoxycarbonyl-3-pyridinecarboxylic acid

1215080-63-9

(2R)-1-(phenylthio)-3-(tetrahydro-2H-pyran-2-yloxy)propan-2-yl 2-(2,3-dichlorobenzylidene)-3-oxobutanoate

1352187-22-4

3-ethyl 5-((R)-1-hydroxy-3-(phenylsulfonyl)propan-2-yl) (R)-4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

127634-13-3

(S)-4-(2,3-dichlorophenyl)-5-(ethoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylic acid

上游原料

甲基碘甲醇钠 (S)-4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-5-pivaloyloxymethoxycarbonyl-3-pyridinecarboxylic acid (2R)-1-(phenylthio)-3-(tetrahydro-2H-pyran-2-yloxy)propan-2-yl 2-(2,3-dichlorobenzylidene)-3-oxobutanoate 3-ethyl 5-((R)-1-hydroxy-3-(phenylsulfonyl)propan-2-yl) (R)-4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate (S)-4-(2,3-dichlorophenyl)-5-(ethoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylic acid (R)-(+)-4-(2,3-dichlorophenyl)-1,4-dihydro-5-methoxycarbonyl-2,6-dimethyl-3-pyridinecarboxylic acid (R)-3-ethyl 5-((R)-1-hydroxy-3-(phenylthio)propan-2-yl) 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate 非洛地平 3-ethyl 5-((R)-1-hydroxy-3-tosylpropan-2-yl) (R)-4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate (4S)-3-ethyl 5-(1-(phenylthio)-3-(tetrahydro-2H-pyran-2-yloxy)propan-2-yl) 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate