化合物简介
Phenibut (fenibut, phenybut; brand names Noofen and Citrocard), contracted from β-phenyl-γ-aminobutyric acid (β-phenyl-GABA), is a central depressant and analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA), or a GABA analogue. The addition of a phenyl ring allows phenibut to cross the blood–brain barrier. Phenibut was developed in the Soviet Union in the 1960s, and has since been used there as a pharmaceutical drug to treat a wide range of ailments, including posttraumatic stress disorder, anxiety, depression, asthenia, insomnia, alcoholism, stuttering, and vestibular disorders, among other conditions. In some other parts of the world, phenibut is not approved for clinical use, and is instead sold as a nutritional supplement. It has been reported by some researchers to possess nootropic actions for its ability to improve neurological functions,[medical citation needed] but others have not observed these effects. It is generally accepted that phenibut has anxiolytic effects in both animal models and in humans.
基本信息
中文名称
4-氨基-3-苯基丁酸盐酸盐
英文名称
4-Amino-3-phenylbutyric acid hydrochloride
中文别名
3’-氯苯丙酮、4-氨基-3-苯基丁酸
英文别名
fenigama、PHENIBUT、pgaba、FENIBUT、phenigama、Benzenepropanoic acid, β-(aminomethyl)-、fenigam、Phenygam、phenylgam、Phenybut、phenigam
CAS号
1078-21-3
分子式
C10H14ClNO2
分子量
215.677
精确质量
215.071
PSA
63.32
LOGP
2.7059
编号系统
EINECS号
214-079-6
物化性质
熔点
194.0-202.0°C
安全信息
海关编码
2922499990
危险品标志
Xi
生产方法及用途
用途
菲尼布特用作抗抑郁药。
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