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2-{4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2- fluorophenyl}acetohydrazide

2-{4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2- fluorophenyl}acetohydrazide

CAS号:1093987-89-3
英文名:2-{4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2- fluorophenyl}acetohydrazide
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3-chloro-5-[(6-chloro-3-{[5-(3,5-dimethyl-1-{[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}-1H-pyrazol-4-yl)-1,3,4-oxadiazol-2-yl]methyl}-2-fluorophenyl)oxy]benzonitrile N'-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetyl)-4-methyl-2-(methylsulfonyl)-1H-imidazole-5-carbohydrazide 3-[5-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1,3,4-oxadiazol-2-yl]-N-cyclopropylbenzamide 3-chloro-5-{[6-chloro-2-fluoro-3-({5-[3-fluoro-2-methyl-4-(methyloxy)phenyl]-1,3,4-oxadiazol-2-yl}methyl)phenyl]oxy}benzonitrile 4-chloro-3-[5-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1,3,4-oxadiazol-2-yl]-N-cyclopropylbenzenesulfonamide 3-[5-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1,3,4-oxadiazol-2-yl]-N-[2-(4-morpholinyl)ethyl]benzamide 3-chloro-5-[(6-chloro-2-fluoro-3-{[5-(2-methyl-4-{[2-(4-morpholinyl)ethyl]oxy}phenyl)-1,3,4-oxadiazol-2-yl]methyl}phenyl)oxy]benzonitrile 3-[5-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1,3,4-oxadiazol-2-yl]-N-[2-(methylsulfonyl)ethyl]benzamide 3-chloro-5-{[6-chloro-3-({[5-chloro-2-(methylthio)-4-pyridinyl]-1,3,4-oxadiazol-2-yl}methyl)-2-fluorophenyl]oxy}benzonitrile 3-[5-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1,3,4-oxadiazol-2-yl]-N-[(2,2-dimethyl-1,3-dioxolan-4-yl)methyl]benzamide 3-chloro-5-[(6-chloro-2-fluoro-3-{[5-(4-methyl-1H-imidazol-5-yl)-1,3,4-oxadiazol-2-yl]methyl}phenyl)oxy]benzonitrile 3-chloro-5-[(6-chloro-3-{[5-(4-{[3-(dimethylamino)propyl]oxy}-2-methylphenyl)-1,3,4-oxadiazol-2-yl]methyl}-2-fluorophenyl)oxy]benzonitrile 3-[5-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1,3,4-oxadiazol-2-yl]-N-(2,3-dihydroxypropyl)benzamide 3-[5-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1,3,4-oxadiazol-2-yl]-N-(3-hydroxypropyl)benzamide 3-chloro-5-[(6-chloro-2-fluoro-3-{[5-(2-methyl-4-{[3-(4-morpholinyl)propyl]oxy}phenyl)-1,3,4-oxadiazol-2-yl]methyl}phenyl)oxy]benzonitrile N'-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetyl)-5-methyl-2-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-4-pyridinecarbohydrazide 3-chloro-5-{[6-chloro-2-fluoro-3-({5-[4-methyl-2-(methylsulfonyl)-1H-imidazol- 5-yl]-1,3,4-oxadiazol-2-yl}methyl)phenyl]oxy}benzonitrile 3-chloro-5-[(6-chloro-2-fluoro-3-{[5-(4-hydroxy-2-methylphenyl)-1,3,4-oxadiazol-2-yl]methyl}phenyl)oxy]benzonitrile 3-chloro-5-[(6-chloro-2-fluoro-3-{[5-(4-methyl-1H-pyrazol-5-yl)-1,3,4-oxadiazol-2-yl]methyl}phenyl)oxy]benzonitrile 3-[(3-{[5-(3-amino-5-methyl-1H-pyrazol-4-yl)-1,3,4-oxadiazol-2-yl]methyl}-6-chloro-2-fluorophenyl)oxy]-5-chlorobenzonitrile 3-(3-((5-(2-bromo-3-hydroxy-4,6-dimethylphenyl)-1,3,4-oxadiazol-2-yl)methyl)-6-chloro-2- fluorophenoxy)-5-chlorobenzonitrile 3-chloro-5-[(6-chloro-3-{[5-(1,4-dimethyl-1H-imidazol-5-yl)-1,3,4-oxadiazol-2-yl]methyl}-2-fluorophenyl)oxy]benzonitrile 3-chloro-5-{[6-chloro-2-fluoro-3-({5-[5-methyl-2-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-4-pyridinyl]-1,3,4-oxadiazol-2-yl}methyl)phenyl]oxy}benzonitrile 3-chloro-5-(6-chloro-2-fluoro-3-((5-(4-methyl-2-(pyridin-4-yl)-1H-imidazol-5-yl)-1,3,4-oxadiazol-2-yl)methyl)phenoxy)benzonitrile 3-chloro-5-({6-chloro-3-[(5-{3,5-dimethyl-1-[2-(methylsulfonyl)ethyl]-1H-pyrazol-4-yl}-1,3,4-oxadiazol-2-yl)methyl]-2-fluorophenyl}oxy)benzonitrile N'-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetyl)-2-{[(2S)-2,3-dihydroxy-3-methylbutyl]oxy}-5-methyl-4-pyridinecarbohydrazide 3-[(3-{[5-(5-amino-2-methylphenyl)-1,3,4-oxadiazol-2-yl]methyl}-6-chloro-2-fluorophenyl)oxy]-5-chlorobenzonitrile 3-chloro-5-[(6-chloro-3-{[5-(6-{[(2S)-2,3-dihydroxy-3-methylbutyl]oxy}-2-methyl-3-pyridinyl)-1,3,4-oxadiazol-2-yl]methyl}-2-fluorophenyl)oxy]benzonitrile 3-chloro-5-[(6-chloro-3-{[5-(2-{[(2S)-2,3-dihydroxy-3-methylbutyl]oxy}-5-methyl-4-pyridinyl)-1,3,4-oxadiazol-2-yl]methyl}-2-fluorophenyl)oxy]benzonitrile 3-chloro-5-({6-chloro-3-[(5-{1-[(2S)-2,3-dihydroxy-3-methylbutyl]-3,5-dimethyl-1H-pyrazol-4-yl}-1,3,4-oxadiazol-2-yl)methyl]-2-fluorophenyl}oxy)benzonitrile N'-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetyl)-4-methyl-1H-pyrazole-5-carbohydrazide 3-chloro-5-{[6-chloro-2-fluoro-3-({5-[4-methyl-6-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-3-pyridinyl]-1,3,4-oxadiazol-2-yl}methyl)phenyl]oxy}benzonitrile 3-[5-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1,3,4-oxadiazol-2-yl]benzamide 3-chloro-5-{[6-chloro-2-fluoro-3-({5-[2-methyl-6-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-3-pyridinyl]-1,3,4-oxadiazol-2-yl}methyl)phenyl]oxy}benzonitrile 3-chloro-5-[(6-chloro-3-{[5-(6-{[(2S)-2,3-dihydroxy-3-methylbutyl]oxy}-4-methyl-3-pyridinyl)-1,3,4-oxadiazol-2-yl]methyl}-2-fluorophenyl)oxy]benzonitrile 3-[5-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1,3,4-oxadiazol-2-yl]benzoic acid 3-chloro-5-{[6-chloro-3- ({5-[(1E)-1-cyano-2-(ethyloxy)-1-propen-1-yl]-1,3,4-oxadiazol-2-yl}methyl)-2- fluorophenyl]oxy}benzonitrile 1,1-dimethylethyl (3R)-3-[({4-[5-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1,3,4-oxadiazol-2-yl]-3-methylphenyl}oxy)methyl]-1-piperidinecarboxylate 3-chloro-5-{[6-chloro-3-({5-[(1Z)-1-cyano-2-(ethyloxy)-1-propen-1-yl]-1,3,4-oxadiazol-2-yl}methyl)-2-fluorophenyl]oxy}benzonitrile 3-chloro-5-({6-chloro-2-fluoro-3-[(5-{4-[(2-hydroxy-2-methylpropyl)oxy]-2-methylphenyl}-1,3,4-oxadiazol-2-yl)methyl]phenyl}oxy)benzonitrile 3-chloro-5-[(6-chloro-2-fluoro-3-{[5-(4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl)-1,3,4-oxadiazol-2-yl]methyl}phenyl)oxy]benzonitrile 3-chloro-5-(6-chloro-3-((5-(4-chloro-2-ethyl-1H-imidazol-5-yl)-1,3,4-oxadiazol-2-yl)methyl)-2-fluorophenoxy)benzonitrile 3-chloro-5-[(6-chloro-3-{[5-(1,4-dimethyl-1H-pyrazol-5-yl)-1,3,4-oxadiazol-2-yl]methyl}-2-fluorophenyl)oxy]benzonitrile 3-chloro-5-[(6-chloro-2-fluoro-3-{[5-(4-methyl-2-{[2-(methylsulfonyl)ethyl]amino}-1,3-thiazol-5-yl)-1,3,4-oxadiazol-2-yl]methyl}phenyl)oxy]benzonitrile 1,1-dimethylethyl 4-[(2S)-3-({4-[5-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1,3,4-oxadiazol-2-yl]-3-methylphenyl}oxy)-2-hydroxypropyl]-1-piperazinecarboxylate 3-chloro-5-{[6-chloro-2-fluoro-3-({5-[4-methyl-2-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-1,3-thiazol-5-yl]-1,3,4-oxadiazol-2-yl}methyl)phenyl]oxy}benzonitrile