百科

2'-beta-氟-2',3'-二脱氧腺苷

CAS号：110143-10-7

英文名：[(2S,4S,5R)-5-(6-aminopurin-9-yl)-4-fluorooxolan-2-yl]methanol

分子式

C10H12FN5O2

熔点

密度

1.85g/cm3

分子量

253.233

沸点

541.3ºC at 760mmHg

溶解度

信号词

危险品标志

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化合物简介

Lodenosine is a failed experimental agent for the treatment of HIV. Its development was discontinued on January 11, 2001.

基本信息

中文名称

2'-beta-氟-2',3'-二脱氧腺苷

英文名称

[(2S,4S,5R)-5-(6-aminopurin-9-yl)-4-fluorooxolan-2-yl]methanol

中文别名

英文别名

2\'-F-dd-ara-A、Lodenosine、2\'-FddA、DRG-0246、F-ddA、Lodenosine (USAN)

CAS号

110143-10-7

分子式

C10H12FN5O2

分子量

253.233

精确质量

253.098

PSA

99.08

LOGP

0.6076

物化性质

密度

1.85g/cm3

沸点

541.3ºC at 760mmHg

闪点

281.2ºC

折射率

1.795

蒸汽压

1.5E-12mmHg at 25°C

安全信息

海关编码

2934999090

合成路线

共找到2条合成路线 >

234436-55-6

9-[2,3-dideoxy-2-fluoro-5-O-(triphenylmethyl)-β-D-threo-pentofuranosyl]-9H-purine-6-amine

110143-10-7

2'-beta-氟-2',3'-二脱氧腺苷

上游原料

共找到49个上游原料 >

20187-82-0

9-(2-Deoxy-2-fluoro-α-D-arabinofuranosyl)-9H-purin-6-amine

144924-99-2

9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-N6 -benzoyladenine

135473-20-0

((2S,4S,5R)-5-(6-chloro-9H-purin-9-yl)-4-fluorotetrahydrofuran-2-yl)methyl benzoate

125542-17-8

9-[5-O-(tert-butyldimethylsilyl)-2-deoxy-2-fluoro-3-O-(phenoxythiocarbonyl)-β-D-arabinofuranosyl]adenine

84025-00-3

1,3-di-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-D-arabinofuranose

90813-62-0

9-(3-deoxy-5-O-trityl-β-D-erythro-pentofuranosyl)adenine

下游产品

[(2S,4S,5R)-4-fluoro-5-(1-hydroxy-6-iminopurin-9-yl)oxolan-2-yl]methanol

上游原料

9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-N6 -benzoyladenine ((2S,4S,5R)-5-(6-chloro-9H-purin-9-yl)-4-fluorotetrahydrofuran-2-yl)methyl benzoate 9-[5-O-(tert-butyldimethylsilyl)-2-deoxy-2-fluoro-3-O-(phenoxythiocarbonyl)-β-D-arabinofuranosyl]adenine 1,3-di-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-D-arabinofuranose 9-(3-deoxy-5-O-trityl-β-D-erythro-pentofuranosyl)adenine 9-(3-O-phenoxythiocarbonyl-5-O-trityl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine 6-chloro-9-[3-deoxy-2-O-[(trifluoromethyl)sulfonyl]-5-O-(triphenylmethyl)-β-D-erythro-pentofuranosyl]-9H-purine 6-chloro-9-(3-O-benzoyl-β-D-ribofuranosyl)purine 2-脱氧-2-氟-1,3,5-三苯甲酰基-alpha-D-阿拉伯呋喃糖 5'-O-trityl-3'-O-benzoyl-2'-O-trifluoromethanesulfonyl-6-chloropurine riboside 9-(2-deoxy-2-fluoro-5-O-tetrahydropyran-2-yl-β-D-ribofuranosyl)adenine (S)-(4-fluoro-5-oxo-2,5-dihydrofuran-2-yl)methyl 4-methylbenzoate 6-chloro-9-(3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purine N6-苯甲酰-2'-氟脱氧腺苷 2-Deoxy-2-fluoro-1-O-methyl-β-D-arabinofuranose 9-[3-O-benzoyl-5-O-(triphenylmethyl)-β-D-ribofuranosyl]-6-chloro-9H-purine 6-chloro-9-(5′-O-trityl-β-D-ribofuranosyl)purine 虫草素 9-(5-O-trityl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine 9-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-2-fluoro-β-D-arabinofuranosyl]-N6 -benzoyladenine 2',5'-di-O-acetyl-3'-deoxyinosine 6-amino-9-[5-O-(tert-butyldimethylsilyl)-2-deoxy-2-fluoro-β-D-arabinofuranosyl]-9H-purine (S)-(-)-2-Fluoro-4-(hydroxymethyl)-2-buten-4-olide (6-chloropurin-9-yl)-trimethylsilane 9-(5-O-trityl-3-O-methylthiothiocarbonyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl) adenine 6-chloro-9-(3-deoxy-β-D-erythro-pentofuranosyl)-9H-purine 9-[2,3-dideoxy-2-fluoro-5-O-(triphenylmethyl)-β-D-threo-pentofuranosyl]-9H-purine-6-amine 2-脱氧-1-溴-2-氟-3,5-二苯甲酰基-alpha-D-阿拉伯呋喃糖 6-氯嘌呤核苷 9-(2,5-di-O-acetyl-3-bromo-3-deoxy-β-D-xylofuranosyl)-1,9-dihydro-6H-purine-6-one 1,3-di-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-D-arabinofuranosyl bromide 肌苷 9-(3-O-benzyl-2-deoxy-2-fluoro-5-O-tetrahydropyran-2-yl-β-D-ribofuranosyl)adenine 6-chloro-9-[3-deoxy-5-O-(triphenylmethyl)-β-D-erythro-pentofuranosyl]-9H-purine 5-O-Benzoyl-2-deoxy-2-fluoro-1-O-methyl-β-D-arabinofuranose (3R,5S)-3-fluoro-5-(p-toluoyloxymethyl)-2-tetrahydrofuranone N6-benzoyl-2'-deoxy-2'-fluoro-5'-O-(4,4'-dimethoxytrityl)adenosine (3R,5S,5S)-2-acetoxy-3-fluoro-5-(p-toluoyloxymethyl)tetrahydrofuran 9-(2,3-deoxy-2-fluoro-5-O-tetrahydropyran-2-yl-β-D-glycero-pent-2-enofuranosyl)adenine 6-chloro-9-[3-deoxy-2-O-(sulfurylimidazolyl)-5-O-(triphenylmethyl)-β-D-erythro-pentofuranosyl]-9H-purine 9-(5-O-acetyl-3-deoxy-β-D-erythro-pentofuranosyl)-6-chloro-9H-purine 5-O-Benzoyl-2-deoxy-2-fluoro-1-O-methyl-3-O-(methylthio)thiocarbonyl-β-D-arabinofuranose 6-氯嘌呤 (2R,3R,4R,5R)-2-(6-chloro-9H-purin-9-yl)-4-hydroxy-5-((trityloxy)methyl)tetrahydrofuran-3-yl benzoate 9-[3-O-苯甲酰基-2-脱氧-2-氟-5-O-(三苯基甲基)-beta-D-呋喃阿拉伯糖基]-6-氯-9H-嘌呤

下游产品

地丹诺辛 [(2S,4S,5R)-4-fluoro-5-(1-hydroxy-6-iminopurin-9-yl)oxolan-2-yl]methanol