化合物简介
Roxindole (EMD-49,980) is a dopaminergic and serotonergic drug which was originally developed for the treatment of schizophrenia. In clinical trials its antipsychotic efficacy was only modest but it was unexpectedly found to produce potent and rapid antidepressant and anxiolytic effects. As a result, roxindole was further researched for the treatment of depression instead. It has also been investigated as a therapy for Parkinson's disease and prolactinoma.
基本信息
中文名称
罗新朵
英文名称
roxindole
中文别名
罗克吲哚、3-[4-(3,6-二氢-4-苯基-1(2H)-吡啶)丁基]-1H-吲哚-5-醇盐酸盐
英文别名
Roxindole、RoxindoleHCl、Roxindole hydrochloride,3-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)butyl]-1H-indol-5-olhydrochloride、ROXINDOLE HYDROCHLORIDE
CAS号
112192-04-8
分子式
C23H26N2O
分子量
346.465
精确质量
346.205
PSA
39.26
LOGP
4.9234
编号系统
UNII
43227SMS0O
物化性质
密度
1.173g/cm3
沸点
575.7ºC at 760mmHg
闪点
302ºC
折射率
1.651
蒸汽压
7.46E-14mmHg at 25°C
安全信息
海关编码
2933990090