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1,4-二脱氧-1,4-亚氨基-d-甘露醇盐酸盐

CAS号：114976-76-0

英文名：1,4-Dideoxy-1,4-imino-D-mannitol, Hydrochloride

分子式

C6H14ClNO4

熔点

147-148ºC

密度

1.492g/cm3

分子量

199.633

沸点

448.6ºC at 760mmHg

溶解度

信号词

危险品标志

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化合物简介

A competitive glycosidase inhibitor. It is also a glycoprotein mannosidase inhibitor - inhibiting jack bean, and to a lesser extent lysosomal alpha-mannosidase. It is an azofuranose analog of mannose, and is structurally related to swainsonine.

基本信息

中文名称

1,4-二脱氧-1,4-亚氨基-d-甘露醇盐酸盐

英文名称

1,4-Dideoxy-1,4-imino-D-mannitol, Hydrochloride

中文别名

英文别名

1,4-DIDEOXY-1,4-IMINO-D-MANNITOL HYDROCHLORIDE

CAS号

114976-76-0

分子式

C6H14ClNO4

分子量

199.633

精确质量

199.061

PSA

92.95

LOGP

-1.836

编号系统

MDL号

MFCD01310868

物化性质

密度

1.492g/cm3

沸点

448.6ºC at 760mmHg

熔点

147-148ºC

闪点

258ºC

储存条件

2-8ºC

蒸汽压

6.21E-10mmHg at 25°C

安全信息

安全说明

S26; S36

危险类别码

R36/37/38

海关编码

2933990090

危险品标志

合成路线

180182-35-8

(S)-1-((3aS,4R,6aR)-2,2-dimethyl-5-(9-phenyl-9H-fluoren-9-yl)tetrahydro-3aH-[1,3]dioxolo[4,5-c]pyrrol-4-yl)-2-(methoxymethoxy)ethanol

114976-76-0

1,4-二脱氧-1,4-亚氨基-d-甘露醇盐酸盐

上游原料

(2S,3S,4R)-N-benzyl-2-[(1'S)-1,2-dihydroxyethyl]-3,4-(isopropylidenedioxy)pyrrolidine

132430-78-5

(2S,3S,4R)-N-benzyl-2-formyl-3,4-(isopropylidenedioxy)pyrrolidine

160882-76-8

(2S)-4-氧代-1-(9-苯基芴基)-脯氨酸甲酯

668994-35-2

(S)-1-benzyl-2,5-dihydro-2-((S)-2',2'-dimethyl-1',3'-dioxolan-4'-yl)-1H-pyrrole

668994-37-4

(2S,3S,4R)-1-benzyl-2-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)pyrrolidine-3,4-diol

上游原料

L-羟基脯氨酸 (2S,3S,4R)-N-benzyl-2-[(1'S)-1,2-dihydroxyethyl]-3,4-(isopropylidenedioxy)pyrrolidine (2S,3S,4R)-N-benzyl-2-formyl-3,4-(isopropylidenedioxy)pyrrolidine (2S)-4-氧代-1-(9-苯基芴基)-脯氨酸甲酯 (S)-1-benzyl-2,5-dihydro-2-((S)-2',2'-dimethyl-1',3'-dioxolan-4'-yl)-1H-pyrrole (2S,3S,4R)-1-benzyl-2-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)pyrrolidine-3,4-diol 2S)-(4R (2S,3S,4R)-N-benzyl-3,4-(isopropylidenedioxy)-2-vinyl-pyrrolidine (2R,3S,4S)-2-(benzyloxy)-4-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-nitrobutane-1,3-diol 1-((3aS,4S,6aR)-2,2-dimethyl-5-(9-phenyl-9H-fluoren-9-yl)tetrahydro-4H-[1,3]dioxolo[4,5-c]pyrrol-4-yl)-2-(methoxymethoxy)ethan-1-one 反式-4-羟基-L-脯氨酸甲酯盐酸盐 (S)-N-allyl-N-benzyl-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)prop-2-en-1-amine (2S,3S,4R)-3,4-dihydroxy-N-(9'-phenylfluoren-9'-yl)pyrrolidine-2-carboxylic acid methyl ester (S)-1-((3aS,4R,6aR)-2,2-dimethyl-5-(9-phenyl-9H-fluoren-9-yl)tetrahydro-3aH-[1,3]dioxolo[4,5-c]pyrrol-4-yl)-2-(methoxymethoxy)ethanol (3aS,4S,6aR)-2,2-Dimethyl-5-(9-phenyl-9H-fluoren-9-yl)-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole-4-carboxylic acid methyl ester