6-羟基地氯雷他定

6-羟基地氯雷他定

CAS号：119410-05-8

英文名：8-chloro-11-piperidin-4-ylidene-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridin-6-ol

分子式

C19H19ClN2O

熔点

密度

1.3g/cm3

分子量

326.82

沸点

520.3ºC at 760 mmHg

溶解度

信号词

危险品标志

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化合物简介

A hydroxylated metabolite of Desloratadine.

基本信息

中文名称

6-羟基地氯雷他定

英文名称

8-chloro-11-piperidin-4-ylidene-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridin-6-ol

中文别名

英文别名

6-OH desloratadine、6-Hydroxy Desloratadine

CAS号

119410-05-8

分子式

C19H19ClN2O

分子量

326.82

精确质量

326.119

PSA

45.15

LOGP

3.8386

物化性质

密度

1.3g/cm3

沸点

520.3ºC at 760 mmHg

闪点

268.5ºC

折射率

1.649

蒸汽压

1.19E-11mmHg at 25°C

合成路线

8-Chloro-5,11-dihydro-11-(4-piperidinylidene)-6H-benzo(5,6)cyclohepta(1,2-b)pyridin-6-one

8-Chloro-5,11-dihydro-11-(4-piperidinylidene)-6H-benzo(5,6)cyclohepta(1,2-b)pyridin-6-one

6-羟基地氯雷他定

6-羟基地氯雷他定

上游原料

共找到8个上游原料 >

Ethyl 4-(8-Chloro-5,6-dihydro-6-oxo-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-1-piperidinecarboxylate

Ethyl 4-(8-Chloro-5,6-dihydro-6-oxo-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-1-piperidinecarboxylate

8-Chloro-6-methoxy-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

8-Chloro-6-methoxy-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

8-Chloro-5,11-dihydro-11-(1-methyl-4-piperidinylidene)-6H-benzo<5,6>cyclohepta<1,2-b>pyridin-6-one

8-Chloro-5,11-dihydro-11-(1-methyl-4-piperidinylidene)-6H-benzo<5,6>cyclohepta<1,2-b>pyridin-6-one

8-Chloro-5,11-dihydro-11-(4-piperidinylidene)-6H-benzo(5,6)cyclohepta(1,2-b)pyridin-6-one

8-Chloro-5,11-dihydro-11-(4-piperidinylidene)-6H-benzo(5,6)cyclohepta(1,2-b)pyridin-6-one

6-methoxy-8-chloro-11-(1-methyl-4-piperidinyl)-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ol

6-methoxy-8-chloro-11-(1-methyl-4-piperidinyl)-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ol

8-氯-5,6-二氢-11H-苯并[5,6]环庚烷并[1,2-b]吡啶-11-酮

8-氯-5,6-二氢-11H-苯并[5,6]环庚烷并[1,2-b]吡啶-11-酮

上游原料

Ethyl 4-(8-Chloro-5,6-dihydro-6-oxo-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-1-piperidinecarboxylate 8-Chloro-6-methoxy-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one 8-Chloro-5,11-dihydro-11-(1-methyl-4-piperidinylidene)-6H-benzo<5,6>cyclohepta<1,2-b>pyridin-6-one 8-Chloro-5,11-dihydro-11-(4-piperidinylidene)-6H-benzo(5,6)cyclohepta(1,2-b)pyridin-6-one 6-methoxy-8-chloro-11-(1-methyl-4-piperidinyl)-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ol 8-氯-5,6-二氢-11H-苯并[5,6]环庚烷并[1,2-b]吡啶-11-酮 8-chloro-11H-benzo[5,6]-cyclohepta[1,2-b]pyridin-11-one Ethyl 4-[8-Chloro-6-[(ethoxycarbonyl)oxy]-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene]-1-piperidinecarboxylate