化合物简介
Cetrorelix acetate (INN, USAN, BAN) (trade name Cetrotide) is an injectable gonadotropin-releasing hormone (GnRH) antagonist. A synthetic decapeptide, it is used is used in assisted reproduction to inhibit premature luteinizing hormone surges The drug works by blocking the action of GnRH upon the pituitary, thus rapidly suppressing the production and action of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). In addition, cetrorelix can be used to treat hormone-sensitive cancers of the prostate and breast (in pre-/perimenopausal women) and some benign gynaecological disorders (endometriosis, uterine fibroids and endometrial thinning). It is administered as either multiple 0.25mg daily subcutaneous injections or as a single-dose 3mg subcutaneous injection. The duration of the 3mg single dose is four days; if hCG is not administered within four days, a daily 0.25mg dose is started and continued until hCG is administered.
基本信息
中文名称
醋酸西曲瑞克
英文名称
cetrorelix
中文别名
醋酸西曲瑞克 CETRORELIXACETATE
英文别名
AC-D-2-NAL-4-CHLORO-D-PHE-B-(3-PYRIDYL)-D-ALA-SER-TYR-D-CIT-LEU-ARG-PRO-D-ALA-NH2、CETRORELIX ACETATE(CETROTIDE)、CETRIZINEDIHYDROCHLORIDE、Cetrorelixacetate、Cetrorelixum [inn-latin]、CETRORELIX、Ac-D-Nal-D-Cpa-D-Pal-Ser-Tyr-D-Cit-Leu-Arg-Pro-D-Ala-NH2、N-Acetyl-3-(2-naphthalenyl)-D-Ala-4-chloro-D-Phe-3-(3-pyridyl)-D-Ala-L-Ser-L-Tyr-N5-(aminocarbonyl)-D-Orn-L-Leu-L-Arg-L-Pro-D-Ala-NH2、Ac-DNal-DpCl-Phe-DPal-Ser-Tyr-DCit-Leu-Arg-Pro-D-Ala-NH2、Cetrorelix acetate、AC-(D-ALA[3-(2-NAPHTHYL)])-[D-PHE(4-CL)]-(D-ALA[3-(3-PYRIDYL)])-SER-TYR-(D-CIT)-LEU-ARG-PRO-D-ALA-OH、Unii-oon1hfz4ba、CETRORELIX ACID、Cetrorelixum、Ac-D-2-Nal-4-chloro-D-Phe-b-(3-pyridyl)-D-Ala-Ser-Tyr-D-Cit-Leu-Arg-Pro-D-Ala-NH2
CAS号
120287-85-6
分子式
C70H92ClN17O14
分子量
1431.04
精确质量
1429.67
PSA
495.67
LOGP
5.9323
物化性质
外观与性状
白色粉末
密度
1.42g/cm3
折射率
1.667
合成路线
