化合物简介
Rivastigmine (sold under the trade name Exelon) is a parasympathomimetic or cholinergic agent for the treatment of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease. The drug can be administered orally or via a transdermal patch; the latter form reduces the prevalence of side effects, which typically include nausea and vomiting. The drug is eliminated through the urine, and appears to have relatively few drug-drug interactions.
基本信息
中文名称
利凡斯的明
英文名称
rivastigmine
中文别名
利斯的明、N-乙基-N-甲基-氨基甲酸 3-[(S)-1-(二甲氨基)乙基]苯酯
英文别名
N-Ethyl-N-methylcarbamic acid 3-[(1S)-1-(dimethylamino)ethyl]phenyl-ester、[3-[(1S)-1-(dimethylamino)ethyl]phenyl] N-ethyl-N-methylcarbamate、Rivastigmine
CAS号
123441-03-2
分子式
C18H28N2O8
分子量
400.424
精确质量
400.185
PSA
147.84
LOGP
0.6371
编号系统
UNII
PKI06M3IW0
物化性质
密度
1.038g/cm3
沸点
316.2ºC at 760mmHg
闪点
145ºC
折射率
1.518
蒸汽压
0.000416mmHg at 25°C
上游原料
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