化合物简介
Prulifloxacin is an older synthetic antibiotic of the fluoroquinolone drug class undergoing clinical trials prior to a possible NDA (New Drug Application) submission to the U.S. Food and Drug Administration (FDA). It is a prodrug which is metabolized in the body to the active compound ulifloxacin. It was developed over two decades ago by Nippon Shinyaku Co. and was patented in Japan in 1987 and in the United States in 1989.
基本信息
中文名称
普卢利沙星
英文名称
Prulifloxacin
中文别名
6-氟-1-甲基-7-[4-(5-甲基-2-氧代-1,3-二氧杂环戊烯-4-基)-甲基-1-哌啶基]-4-氧代-4H-[1,3]硫氮杂环丁烷并[3,2-a]喹啉-3-羧酸、6-氟-1-甲基-7-{4-(5-甲基-2-氧代-1,3-二噁茂烷-4-基)-甲基-1-哌啶基}-4-氧代-1H,4H-[1,3]噻啶并[3,2-A]-3-喹啉羧酸
英文别名
Quisnon、Sword、nm441、SEA BUCKTHORN P.E
CAS号
123447-62-1
分子式
C21H20FN3O6S
分子量
461.463
精确质量
461.106
PSA
134.43
LOGP
2.6427
编号系统
UNII
J42298IESW
物化性质
外观与性状
黄色或略黄色粉末
密度
1.62 g/cm3
沸点
633.2ºC at 760 mmHg
闪点
336.8ºC
折射率
1.698
蒸汽压
1.77E-20mmHg at 25°C
生产方法及用途
用途
喹诺酮类抗生素。
合成路线
上游原料
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