Cryptophycin 1

Cryptophycin 1

CAS号：124689-65-2

英文名：(3S,6R,10R,13E,16S)-10-[(3-chloro-4-methoxyphenyl)methyl]-6-methyl-3-(2-methylpropyl)-16-[(1S)-1-[(2R,3R)-3-phenyloxiran-2-yl]ethyl]-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone

分子式

C35H43ClN2O8

熔点

密度

1.171g/cm3

分子量

655.178

沸点

889.4ºC at 760 mmHg

溶解度

信号词

危险品标志

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基本信息

中文名称

Cryptophycin 1

英文名称

(3S,6R,10R,13E,16S)-10-[(3-chloro-4-methoxyphenyl)methyl]-6-methyl-3-(2-methylpropyl)-16-[(1S)-1-[(2R,3R)-3-phenyloxiran-2-yl]ethyl]-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone

中文别名

英文别名

10-((3-Chloro-4-methoxyphenyl)methyl)-6-methyl-3-(2-methylpropyl)-16-(1-(3-phenyloxiranyl)ethyl)-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone、CRYPTOPHYCIN A、C35H43ClN2O8、1,4-Dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone,10-((3-chloro-4-methoxyphenyl)methyl)-6-methyl-3-(2-methylpropyl)-16-(1-(3-phenyloxiranyl)ethyl)、cryptophycin、cryptophycin-1

CAS号

124689-65-2

分子式

C35H43ClN2O8

分子量

655.178

精确质量

654.271

PSA

139.54

LOGP

5.2858

物化性质

密度

1.171g/cm3

沸点

889.4ºC at 760 mmHg

闪点

491.7ºC

折射率

1.526

蒸汽压

2.92E-32mmHg at 25°C

安全信息

危险品运输编码

UN 3172

危险类别

6.1(b)

包装等级

III

合成路线

(E)-(3S,6R,10R,16S)-10-(3-Chloro-4-methoxy-benzyl)-16-((1R,2R,3R)-2,3-dihydroxy-1-methyl-3-phenyl-propyl)-3-isobutyl-6-methyl-1,4-dioxa-8,11-diaza-cyclohexadec-13-ene-2,5,9,12-tetraone

(E)-(3S,6R,10R,16S)-10-(3-Chloro-4-methoxy-benzyl)-16-((1R,2R,3R)-2,3-dihydroxy-1-methyl-3-phenyl-propyl)-3-isobutyl-6-methyl-1,4-dioxa-8,11-diaza-cyclohexadec-13-ene-2,5,9,12-tetraone

Cryptophycin 1

上游原料

共找到34个上游原料 >

(S)-benzyl 2-(((R)-3-amino-2-methylpropanoyl)oxy)-4-methylpentanoate

(S)-benzyl 2-(((R)-3-amino-2-methylpropanoyl)oxy)-4-methylpentanoate

(3S,4R,5E)-3-[(tert-butyldimethylsilyl)oxy]-4-methyl-6-phenyl-5-hexenal

(3S,4R,5E)-3-[(tert-butyldimethylsilyl)oxy]-4-methyl-6-phenyl-5-hexenal

(E)-2-methyl-4-phenylbut-3-enal

(E)-2-methyl-4-phenylbut-3-enal

(2S,2'R)-benzyl 2-[(3'-{[(tert-butoxy)carbonyl]amino}-2'-methylpropinoyl)oxy]-4-methylpentanoate

(2S,2'R)-benzyl 2-[(3'-{[(tert-butoxy)carbonyl]amino}-2'-methylpropinoyl)oxy]-4-methylpentanoate

tert-butyl (2E,5S,6R,7E)-5-{[tert-butyl(dimethyl)silyl]oxy}-6-methyl-8-phenylocta-2,7-dienoate

tert-butyl (2E,5S,6R,7E)-5-{[tert-butyl(dimethyl)silyl]oxy}-6-methyl-8-phenylocta-2,7-dienoate

tert-butyl (5S,6R)-5-tert-butyldimethylsilanyloxy-7-hydroxy-6-methylhept-2(E)-enoate

tert-butyl (5S,6R)-5-tert-butyldimethylsilanyloxy-7-hydroxy-6-methylhept-2(E)-enoate

上游原料

(S)-benzyl 2-(((R)-3-amino-2-methylpropanoyl)oxy)-4-methylpentanoate (3S,4R,5E)-3-[(tert-butyldimethylsilyl)oxy]-4-methyl-6-phenyl-5-hexenal (E)-2-methyl-4-phenylbut-3-enal (2S,2'R)-benzyl 2-[(3'-{[(tert-butoxy)carbonyl]amino}-2'-methylpropinoyl)oxy]-4-methylpentanoate tert-butyl (2E,5S,6R,7E)-5-{[tert-butyl(dimethyl)silyl]oxy}-6-methyl-8-phenylocta-2,7-dienoate tert-butyl (5S,6R)-5-tert-butyldimethylsilanyloxy-7-hydroxy-6-methylhept-2(E)-enoate tert-butyl (5S,6R)-5-tert-butyldimethylsilanyloxy-7-(4-methoxybenzyloxy)-6-methylhept-2(E)-enoate (S)-allyl 2-(((R)-3-((R)-2-((tert-butoxycarbonyl)amino)-3-(3-chloro-4-methoxyphenyl)propanamido)-2-methylpropanoyl)oxy)-4-methylpentanoate (E)-(3S,6R,10R,16S)-16-((1R,2R,3R)-3-Chloro-2-hydroxy-1-methyl-3-phenyl-propyl)-10-(3-chloro-4-methoxy-benzyl)-3-isobutyl-6-methyl-1,4-dioxa-8,11-diaza-cyclohexadec-13-ene-2,5,9,12-tetraone (3S,4R)-1-[(tert-butyldimethylsilyl)oxy]-4-methylhex-5-en-3-ol tert-butyl (5S,6R)-5-tert-butyldimethylsilanyloxy-8-iodo-6-methylocta-2(E),7(E)-dienoate tert-butyl (5S,6S)-5-tert-butyldimethylsilanyloxy-6-methyl-7-oxohept-2(E)-enoate (E)-(3S,6R,10R,16S)-10-(3-Chloro-4-methoxy-benzyl)-16-((1R,2R,3R)-2,3-dihydroxy-1-methyl-3-phenyl-propyl)-3-isobutyl-6-methyl-1,4-dioxa-8,11-diaza-cyclohexadec-13-ene-2,5,9,12-tetraone (3S,4R)-3-tert-butyldimethylsilanyloxy-5-(4-methoxybenzyloxy)-4-methylpentanal tert-Butyl-{(S)-1-[(R)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-but-3-enyloxy}-dimethyl-silane (2R,3S)-2-(allyloxy)-3-[(4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]-butyl 4-methylbenzenesulfonate tert-butyl (5S,6R)-5-[(2S)-2-[(2R)-3-[(2R)-2-tert-butoxycarbonylamino-3-(3-chloro-4-methoxyphenyl)propionylamino]-2-methylpropionyloxy]-4-methylpentanoyloxy]-6-methyl-8-phenylocta-2(E),7(E)-dienoate 苄基膦酸二乙酯 tert-butyl (5S,6S,E)-5-(allyloxy)-[(4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]-hept-2-enoate (2E,4e)-5-苯基-2,4-戊二烯酸乙酯 ethyl (2R,3R)-2-(allyloxy)-3-[(4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]-butanoate ethyl (3S)-3-[(4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]butanoate N-乙酰基-O-甲基-D-酪氨酸 (2R)-methyl 2-methyl-2-(trans-styryl)acetate benzyl (-)-2-hydroxyisocaproate (2E,5R,6R,7E)-tert-butyl 5-hydroxy-6-methyl-8-phenylocta-2,7-dienoate (2R,3S)-1-[(4-methoxyphenyl)methoxy]-2-methyl-5-hexen-3-ol tert-butyl (5S,6S,E)-5-(((6R,10R,13S)-6-(3-chloro-4-methoxybenzyl)-13-isobutyl-2,2,10-trimethyl-4,7,11-trioxo-3,12-dioxa-5,8-diazatetradecan-14-oyl)oxy)-6-((4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl)hept-2-enoate (3R,4S)-4,6-bis(tert-butyldimethylsilyloxy)-3-methylhex-1-ene ethyl (E)-3-[(4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]prop-2-enoate (5S,6S,2E)-tert-butyl 6-[(4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]-5-hydroxyhept-2-enoate methyl 4-phenylbut-3-enoate (E)-2-methyl-4-phenyl-3-butenoic acid methyl ester