百科

1-[(2R,3S,4R,5R)-3,4-difluoro-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione

CAS号：125362-07-4

英文名：1-[(2R,3S,4R,5R)-3,4-difluoro-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione

分子式

C10H12F2N2O4

熔点

密度

1.5g/cm3

分子量

262.21

沸点

溶解度

信号词

危险品标志

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基本信息

中文名称

1-[(2R,3S,4R,5R)-3,4-difluoro-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione

英文名称

1-[(2R,3S,4R,5R)-3,4-difluoro-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione

中文别名

英文别名

2\'-F-ribo-FLT、Uridine,2\',3\'-dideoxy-2\',3\'-difluoro-5-methyl

CAS号

125362-07-4

分子式

C10H12F2N2O4

分子量

262.21

精确质量

262.077

PSA

84.58

LOGP

-0.1768

物化性质

密度

1.5g/cm3

折射率

1.544

合成路线

132776-17-1

1-[(2R,3S,4R,5R)-3,4-difluoro-5-(trityloxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione

125362-07-4

1-[(2R,3S,4R,5R)-3,4-difluoro-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione

上游原料

1-[(2R,3S,4R,5R)-3,4-difluoro-5-(trityloxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione

127840-95-3

1-{(2R,3S,4R,5R)-3,4-Difluoro-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

127840-90-8

3-(3,5-di-O-monomethoxytrityl-β-D-arabinofuranosyl)thymine

127840-91-9

1-(2-deoxy-2-fluoro-5-O-monomethoxytrityl-β-D-ribofuranosyl)thymine

124424-31-3

O-2,3-anhydro-1-(5-O-(monomethoxytrityl)-2-deoxy-2-fluoro-β-D-lyxofuranosyl)thymine

上游原料

2,2'-O-脱水-5-甲基尿嘧啶核苷 1-[(2R,3S,4R,5R)-3,4-difluoro-5-(trityloxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione 1-{(2R,3S,4R,5R)-3,4-Difluoro-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione 3-(3,5-di-O-monomethoxytrityl-β-D-arabinofuranosyl)thymine 1-(2-deoxy-2-fluoro-5-O-monomethoxytrityl-β-D-ribofuranosyl)thymine O-2,3-anhydro-1-(5-O-(monomethoxytrityl)-2-deoxy-2-fluoro-β-D-lyxofuranosyl)thymine 1-(2-deoxy-2-fluoro-5-O-monomethoxytrityl-β-D-xylofuranosyl)thymine