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根赤壳菌素

根赤壳菌素

CAS号：12772-57-5

英文名：radicicol

分子式

C18H17ClO6

熔点

190-194ºC

密度

1.364 g/cm3

分子量

364.777

沸点

656.2ºC at 760 mmHg

溶解度

信号词

Danger

危险品标志

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化合物简介

Radicicol, also known as monorden, is a natural product that binds to Hsp90 (Heat Shock Protein 90) and alters its function. HSP90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, angiogenesis and oncogenesis.

基本信息

中文名称

根赤壳菌素

英文名称

radicicol

中文别名

根赤壳霉素

英文别名

KF9-A、humicola fuscoatra、[Biotinyl]-Radicicol、MONORDEN、monorderne、RADISICOL、FO-4910、RADICICOL、[TAMRA]-Radicicol、Monorden/Radicicol、Radicicol from Diheterospora chlamydosporia、MONORODENE

CAS号

12772-57-5

分子式

C18H17ClO6

分子量

364.777

精确质量

364.071

PSA

96.36

LOGP

2.6916

编号系统

MDL号

MFCD01709459

RTECS号

RR1105000

PubChem号

24899351

物化性质

外观与性状

白色/黄色粉末

密度

1.364 g/cm3

沸点

656.2ºC at 760 mmHg

熔点

190-194ºC

闪点

350.7ºC

折射率

1.583

储存条件

-20ºC

蒸汽压

7.97E-18mmHg at 25°C

安全信息

安全说明

S26

危险类别码

R22

危险品运输编码

UN 2811 6.1/PG 3

危险品标志

Xn

危险性防范说明

P201; P280; P308 + P313

危险标志

GHS06, GHS08

信号词

Danger

危险性描述

H301; H340; H350

合成路线

KF 23541

根赤壳菌素

根赤壳菌素

上游原料

共找到40个上游原料 >

(1aR,2Z,4E,14R,15aR)-11-((tert-butyldimethylsilyl)oxy)-9-((tert-butyldiphenylsilyl)oxy)-14-methyl-1a,14,15,15a-tetrahydrospiro[benzo[c]oxireno[2,3-k][1]oxacyclotetradecine-6,2'-[1,3]dithian]-12(7H)-one

(1aR,2Z,4E,14R,15aR)-11-((tert-butyldimethylsilyl)oxy)-9-((tert-butyldiphenylsilyl)oxy)-14-methyl-1a,14,15,15a-tetrahydrospiro[benzo[c]oxireno[2,3-k][1]oxacyclotetradecine-6,2'-[1,3]dithian]-12(7H)-one

6,8-bis((tert-butyldimethylsilyl)oxy)-3-(chloromethyl)-1H-isochromen-1-one

6,8-bis((tert-butyldimethylsilyl)oxy)-3-(chloromethyl)-1H-isochromen-1-one

(R)-1-((2R,3R)-3-vinyloxiran-2-yl)propan-2-yl 2,4-bis(methoxymethoxy)-6-methylbenzoate

(R)-1-((2R,3R)-3-vinyloxiran-2-yl)propan-2-yl 2,4-bis(methoxymethoxy)-6-methylbenzoate

ethyl (E,5S)-5-{[tert-butyl(diphenyl)silyl]oxy}-2-hexenoate

ethyl (E,5S)-5-{[tert-butyl(diphenyl)silyl]oxy}-2-hexenoate

2-chloromethyl-4,6-dihydroxybenzaldehyde

2-chloromethyl-4,6-dihydroxybenzaldehyde

(R)-1-((2R,3R)-3-vinyloxiran-2-yl)propan-2-yl 4-((tert-butyldiphenylsilyl)oxy)-2-hydroxy-6-((2-((1E,3E)-penta-1,3-dien-1-yl)-1,3-dithian-2-yl)methyl)benzoate

(R)-1-((2R,3R)-3-vinyloxiran-2-yl)propan-2-yl 4-((tert-butyldiphenylsilyl)oxy)-2-hydroxy-6-((2-((1E,3E)-penta-1,3-dien-1-yl)-1,3-dithian-2-yl)methyl)benzoate

上游原料

(1aR,2Z,4E,14R,15aR)-11-((tert-butyldimethylsilyl)oxy)-9-((tert-butyldiphenylsilyl)oxy)-14-methyl-1a,14,15,15a-tetrahydrospiro[benzo[c]oxireno[2,3-k][1]oxacyclotetradecine-6,2'-[1,3]dithian]-12(7H)-one 6,8-bis((tert-butyldimethylsilyl)oxy)-3-(chloromethyl)-1H-isochromen-1-one (R)-1-((2R,3R)-3-vinyloxiran-2-yl)propan-2-yl 2,4-bis(methoxymethoxy)-6-methylbenzoate ethyl (E,5S)-5-{[tert-butyl(diphenyl)silyl]oxy}-2-hexenoate 2-chloromethyl-4,6-dihydroxybenzaldehyde (R)-1-((2R,3R)-3-vinyloxiran-2-yl)propan-2-yl 4-((tert-butyldiphenylsilyl)oxy)-2-hydroxy-6-((2-((1E,3E)-penta-1,3-dien-1-yl)-1,3-dithian-2-yl)methyl)benzoate (1aR,2Z,4E,14R,15aR)-9,11-bis(methoxymethoxy)-14-methyl-1a,14,15,15a-tetrahydro-6H-benzo[c]oxireno[2,3-k][1]oxacyclotetradecine-6,12(7H)-dione (E,E)-2,4-己二烯醛 4-tert-butyldiphenylsiloxy-2-chloromethyl-6-hydroxybenzaldehyde (R)-1-((2R,3R)-3-vinyloxiran-2-yl)propan-2-yl 2-((tert-butyldimethylsilyl)oxy)-4-((tert-butyldiphenylsilyl)oxy)-6-((2-((1E,3E)-penta-1,3-dien-1-yl)-1,3-dithian-2-yl)methyl)benzoate (R)-1-((2R,3R)-3-vinyloxiran-2-yl)propan-2-yl 4-((tert-butyldiphenylsilyl)oxy)-2-(chloromethyl)-6-hydroxybenzoate tert-butyldiphenyl(((S)-1-((2R,3S)-3-vinyloxiran-2-yl)propan-2-yl)oxy)silane (1aR,14R,15aR)-9,11-bis(methoxymethoxy)-14-methyl-5-(phenylthio)-1a,4,5,14,15,15a-hexahydro-6H-benzo[c]oxireno[2,3-k][1]oxacyclotetradecine-6,12(7H)-dione (2R,3R,5S)-5-(tert-butyldiphenylsilyl)-2,3-(oxiranyl)hexan-1-al 2,4-dinitrophenyl α-maltotrioside (5S)-5-(tert-butyldiphenylsilyloxy)hex-2-en-1-ol (R)-1-((2R,3R)-3-vinyloxiran-2-yl)propan-2-yl 2,4-bis(methoxymethoxy)-6-(2-oxo-3-(phenylthio)hex-5-en-1-yl)benzoate 4-tert-butyldiphenylsiloxy-2-chloromethyl-6-hydroxybenzoic acid (3R,4R,6S)-6-(tert-butyldiphenylsilyl)-3,4-(oxiranyl)hept-1-ene (R)-1-((2R,3R)-3-vinyloxiran-2-yl)propan-2-yl 2,4-bis(methoxymethoxy)-6-((E)-2-oxohexa-3,5-dien-1-yl)benzoate (3R,4R,6S)-6-(tert-Butyl-diphenyl-silanyloxy)-3-chloro-hept-1-en-4-ol (1aR,2Z,4E,14R,15aR)-9,11-bis(methoxymethoxy)-14-methyl-1a,14,15,15a-tetrahydro-6H-benzo[c]oxireno[2,3-k][1]oxacyclotetradecine-6,12(7H)-dione KF 23541 2-(chloromethyl)-4,6-dimethoxybenzaldehyde (R)-1-((2R,3S)-3-vinyloxiran-2-yl)propan-2-yl 2,4-dihydroxy-6-methylbenzoate (R)-1-((2R,3S)-3-vinyloxiran-2-yl)propan-2-yl 2,4-bis(methoxymethoxy)-6-methylbenzoate 3,5-二甲氧基苄醇 (R)-1-((2R,3R)-3-vinyloxiran-2-yl)propan-2-yl 2,4-dihydroxy-6-methylbenzoate 2-penta-1,3-dienyl-1,3-dithiane (9Z,11E)-(4R,6R,8R)-17,19-Bis-(tert-butyl-dimethyl-silanyloxy)-16-chloro-4-methyl-3,7-dioxa-tricyclo[13.4.0.06,8]nonadeca-1(15),9,11,16,18-pentaene-2,13-dione (S)-1-((2R,3S)-3-vinyloxiran-2-yl)propan-2-ol (3R,4R,6S)-6-(hydroxy)-3,4-(oxiranyl)hept-1-ene 4-戊烯-2-醇 (R)-1-((2R,3S)-3-vinyloxiran-2-yl)propan-2-yl 2,4-bis(methoxymethoxy)-6-(2-oxo-3-(phenylthio)hex-5-en-1-yl)benzoate (9Z,11E)-(4R,6R,8R)-17,19-Bis-(tert-butyl-dimethyl-silanyloxy)-4-methyl-3,7-dioxa-tricyclo[13.4.0.06,8]nonadeca-1(15),9,11,16,18-pentaene-2,13-dione (2R,3R,5S)-5-(tert-butyldiphenylsilyl)-2,3-(oxiranyl)hexan-1-ol 6-(tert-Butyl-dimethyl-silanyloxy)-8-hydroxy-3-[(E)-4-[(2S,3R)-3-((S)-2-hydroxy-propyl)-oxiranyl]-4-(4-methoxy-benzyloxy)-but-2-enyl]-isochromen-1-one 2,4-二羟基-6-甲基苯甲酸 Monocillin I