百科

1-[(2R,3R,4R,5S)-4-azido-3-fluoro-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione

CAS号：127840-94-2

英文名：1-[(2R,3R,4R,5S)-4-azido-3-fluoro-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione

分子式

C10H12FN5O4

熔点

密度

分子量

285.232

沸点

溶解度

信号词

危险品标志

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基本信息

中文名称

1-[(2R,3R,4R,5S)-4-azido-3-fluoro-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione

英文名称

1-[(2R,3R,4R,5S)-4-azido-3-fluoro-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione

中文别名

英文别名

AZdd-2\'-F-methyl-U、3\'-azido-2\',3\'-dideoxy-2\'-fluoro-5-methyluridine

CAS号

127840-94-2

分子式

C10H12FN5O4

分子量

285.232

精确质量

285.087

PSA

134.33

LOGP

-0.38324

合成路线

132776-25-1

1-[(2R,3R,4R,5S)-4-azido-3-fluoro-5-(trityloxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione

127840-94-2

1-[(2R,3R,4R,5S)-4-azido-3-fluoro-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione

上游原料

3-(3,5-di-O-monomethoxytrityl-β-D-arabinofuranosyl)thymine

115913-84-3

5-methyl-1-[(2R,4R)-4-(trityloxymethyl)-3,6-dioxabicyclo[3.1.0]hexan-2-yl]pyrimidine-2,4-dione

127840-91-9

1-(2-deoxy-2-fluoro-5-O-monomethoxytrityl-β-D-ribofuranosyl)thymine

124424-31-3

O-2,3-anhydro-1-(5-O-(monomethoxytrityl)-2-deoxy-2-fluoro-β-D-lyxofuranosyl)thymine

607351-45-1

1-(3-azido-3-deoxy-5-O-trityl-β-D-ribofuranosyl)thymine

上游原料

2,2'-O-脱水-5-甲基尿嘧啶核苷 3-(3,5-di-O-monomethoxytrityl-β-D-arabinofuranosyl)thymine 5-methyl-1-[(2R,4R)-4-(trityloxymethyl)-3,6-dioxabicyclo[3.1.0]hexan-2-yl]pyrimidine-2,4-dione 1-(2-deoxy-2-fluoro-5-O-monomethoxytrityl-β-D-ribofuranosyl)thymine O-2,3-anhydro-1-(5-O-(monomethoxytrityl)-2-deoxy-2-fluoro-β-D-lyxofuranosyl)thymine 1-(3-azido-3-deoxy-5-O-trityl-β-D-ribofuranosyl)thymine 5-甲基尿甙 1,2-di-O-acetyl-3-azido-5-O-(4-methylbenzoyl)-3-deoxy-β-D-ribofuranose O-2,2'-anhydro-1-(3-azido-3-deoxy-5-O-trityl-β-D-arabinofuranosyl)thymine [(2R,3R,4R,5R)-5-(5-methyl-2,4-dioxopyrimidin-1-yl)-4-methylsulfonyloxy-2-(trityloxymethyl)oxolan-3-yl] methanesulfonate 3'-叠氮基-3'-脱氧-5-甲基尿苷 1-[(2R,3S,4S,5S)-4-azido-3-hydroxy-5-(trityloxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione 1-[(2R,3R,4R,5S)-4-azido-3-fluoro-5-(trityloxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione 5-甲基脲嘧啶 ((2S,3R,4R,5R)-4-acetoxy-3-azido-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl 4-methylbenzoate