化合物简介
Pregnanolone (3α-hydroxy-5β-pregnan-20-one or 3α,5β-tetrahydroprogesterone; sometimes abbreviated as 3α,5β-THP), also known as eltanolone (INN), is an endogenous neurosteroid that is biosynthesized from progesterone. It is a positive allosteric modulator of the GABAA receptor, as well as a negative allosteric modulator of the glycine receptor, and is known to have sedative, anxiolytic, anesthetic, and anticonvulsant effects. It was investigated for clinical use as a general anesthetic, but produced unwanted side effects such as convulsions on occasion, and for that reason was never marketed.
基本信息
中文名称
孕烷醇酮
英文名称
3α-hydroxy-5β-pregnan-20-one
中文别名
5α-孕(甾)烷-3β-醇-20-酮、3α-羟基-5β-孕(甾)烷-20-酮、乙他诺隆
英文别名
Pregnanolone II、5-Pregnan-3-ol-20-one、pregnanalone、Pregnan-20-one, 3-hydroxy-, (3α,5β)-、PREGNAN-3A-OL-20-ONE、3alpha-hydroxy-5beta-pregnan-20-one、Pregnan-20-one,3-hydroxy-, (3a,5b)-、Butabindide oxalate
CAS号
128-20-1
分子式
C21H34O2
分子量
318.493
精确质量
318.256
PSA
37.3
LOGP
4.5952
编号系统
MDL号
MFCD00067137
PubChem号
24898909
RTECS号
TU4384000
物化性质
外观与性状
固体
密度
1.05 g/cm3 (20ºC)
沸点
431.2ºC at 760 mmHg
熔点
149ºC
折射率
1.524
稳定性
Stable at normal temperatures and pressures.
储存条件
Keep tightly closed. Store in a cool dry place.
蒸汽压
3.05E-09mmHg at 25°C
安全信息
安全说明
S22; S36
危险类别码
R40
危险品标志
Xn
信号词
Warning
危险性防范说明
P281
危险性描述
H351
危险标志
GHS08
生产方法及用途
用途
激素类药。
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