罗米地辛

罗米地辛

CAS号：128517-07-7

英文名：romidepsin

分子式

C24H36N4O6S2

熔点

密度

1.174g/cm3

分子量

540.696

沸点

942.8ºC at 760 mmHg

溶解度

信号词

危险品标志

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化合物简介

Romidepsin, also known as Istodax, is an anticancer agent used in cutaneous T-cell lymphoma (CTCL) and other peripheral T-cell lymphomas (PTCLs). Romidepsin is a natural product obtained from the bacteria Chromobacterium violaceum, and works by blocking enzymes known as histone deacetylases, thus inducing apoptosis. It is sometimes referred to as depsipeptide, after the class of molecules to which it belongs. Romidepsin is branded and owned by Gloucester Pharmaceuticals, now a part of Celgene.

基本信息

中文名称

罗米地辛

英文名称

romidepsin

中文别名

FK228 罗米地辛

英文别名

Chromadax、Istodax、Romidepsin (FK228,depsipeptide)、Romidepsin、FK-228、Depsipeptide、(1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-di(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetrazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone

CAS号

128517-07-7

分子式

C24H36N4O6S2

分子量

540.696

精确质量

540.208

PSA

193.3

LOGP

2.7448

编号系统

UNII

CX3T89XQBK

物化性质

密度

1.174g/cm3

沸点

942.8ºC at 760 mmHg

闪点

524ºC

折射率

1.529

蒸汽压

0mmHg at 25°C

合成路线

180973-35-7

罗米地辛

上游原料

共找到19个上游原料 >

(5E,7R,11R,14S,17E,20S)-methyl 17-ethylidene-7-hydroxy-11,20-diisopropyl-9,12,15,18-tetraoxo-1,1,1-triphenyl-14-(tritylthiomethyl)-2-thia-10,13,16,19-tetraazahenicos-5-en-21-oate

(5E,7R,11R,14S,17E,20S)-methyl 17-ethylidene-7-hydroxy-11,20-diisopropyl-9,12,15,18-tetraoxo-1,1,1-triphenyl-14-(tritylthiomethyl)-2-thia-10,13,16,19-tetraazahenicos-5-en-21-oate

(5E,7R,11R,14S,17E,20S)-17-ethylidene-7-hydroxy-11,20-diisopropyl-9,12,15,18-tetraoxo-1,1,1-triphenyl-14-(tritylthiomethyl)-2-thia-10,13,16,19-tetraazahenicos-5-en-21-oic acid

(5E,7R,11R,14S,17E,20S)-17-ethylidene-7-hydroxy-11,20-diisopropyl-9,12,15,18-tetraoxo-1,1,1-triphenyl-14-(tritylthiomethyl)-2-thia-10,13,16,19-tetraazahenicos-5-en-21-oic acid

(R,E)-3-hydroxy-7-(tritylthio)hept-4-enoic acid

(R,E)-3-hydroxy-7-(tritylthio)hept-4-enoic acid

methyl (E)-5-(tritylthio)pent-2-enoate

methyl (E)-5-(tritylthio)pent-2-enoate

(3S,4E)-3-羟基-7-[(三苯基甲基)硫基]-4-庚烯酸

(3S,4E)-3-羟基-7-[(三苯基甲基)硫基]-4-庚烯酸

(5E,7S,11R,14S,17E,20S)-17-ethylidene-7-hydroxy-11,20-diisopropyl-9,12,15,18-tetraoxo-1,1,1-triphenyl-14-(tritylthiomethyl)-2-thia-10,13,16,19-tetraazahenicos-5-en-21-oic acid

(5E,7S,11R,14S,17E,20S)-17-ethylidene-7-hydroxy-11,20-diisopropyl-9,12,15,18-tetraoxo-1,1,1-triphenyl-14-(tritylthiomethyl)-2-thia-10,13,16,19-tetraazahenicos-5-en-21-oic acid

上游原料

(5E,7R,11R,14S,17E,20S)-methyl 17-ethylidene-7-hydroxy-11,20-diisopropyl-9,12,15,18-tetraoxo-1,1,1-triphenyl-14-(tritylthiomethyl)-2-thia-10,13,16,19-tetraazahenicos-5-en-21-oate (5E,7R,11R,14S,17E,20S)-17-ethylidene-7-hydroxy-11,20-diisopropyl-9,12,15,18-tetraoxo-1,1,1-triphenyl-14-(tritylthiomethyl)-2-thia-10,13,16,19-tetraazahenicos-5-en-21-oic acid (R,E)-3-hydroxy-7-(tritylthio)hept-4-enoic acid methyl (E)-5-(tritylthio)pent-2-enoate (3S,4E)-3-羟基-7-[(三苯基甲基)硫基]-4-庚烯酸 (5E,7S,11R,14S,17E,20S)-17-ethylidene-7-hydroxy-11,20-diisopropyl-9,12,15,18-tetraoxo-1,1,1-triphenyl-14-(tritylthiomethyl)-2-thia-10,13,16,19-tetraazahenicos-5-en-21-oic acid L-缬氨酸甲酯 N-[(9-fluorenylmethoxy)carbonyl]-L-threonyl-L-valine methyl ester (5E,7S,11R,14S,17E,20S)-methyl 17-ethylidene-7-hydroxy-11,20-diisopropyl-9,12,15,18-tetraoxo-1,1,1-triphenyl-14-(tritylthiomethyl)-2-thia-10,13,16,19-tetraazahenicos-5-en-21-oate (2E)-5-[(triphenylmethyl)thio]-2-pentenal methyl 1,3-butadiene-1-carboxylate methyl ((Z)-2-((S)-2-((R)-2-amino-3-methylbutanamido)-3-(tritylthio)propanamido)but-2-enoyl)-L-valinate benzyl (R,E)-3-hydroxy-7-(tritylthio)hept-4-enoate methyl N-(N-((((9H-fluoren-9-yl)methoxy)carbonyl)-D-valyl)-S-trityl-D-cysteinyl)-O-tosyl-L-threonyl-L-valinate benzyl (S,E)-3-hydroxy-7-(tritylthio)hept-4-enoate (S)-2-((2S,3R)-2-{(S)-2-[(R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-methyl-butyrylamino]-3-tritylsulfanyl-propionylamino}-3-hydroxy-butyrylamino)-3-methyl-butyric acid methyl ester