化合物简介
Ospemifene (commercial name Osphena produced by Shionogi) is an oral medication indicated for the treatment of dyspareunia– pain during sexual intercourse– encountered by some women, more often in those who are post-menopausal. Ospemifene is a selective estrogen receptor modulator (SERM) acting similarly to an estrogen on the vaginal epithelium, building vaginal wall thickness which in turn reduces the pain associated with dyspareunia. Dyspareunia is most commonly caused by \"vulval and vaginal atrophy.\"; The medication was approved by the FDA in February 2013.
基本信息
中文名称
Ospemifene
英文名称
2-[4-[(Z)-4-chloro-1,2-diphenylbut-1-enyl]phenoxy]ethanol
中文别名
英文别名
FC-1271a、Osphena、Fc-1271、Deamino-hydroxytoremifene、Ospemifene、UNII-B0P231ILBK
CAS号
128607-22-7
分子式
C24H23ClO2
分子量
378.891
精确质量
378.139
PSA
29.46
LOGP
5.6457
编号系统
UNII
B0P231ILBK
物化性质
密度
1.166g/cm3
沸点
544.6ºC at 760 mmHg
闪点
283.2ºC
折射率
1.607
蒸汽压
1.08E-12mmHg at 25°C
上游原料
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