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CAS号：129655-21-6

英文名：1,3-bis[2-[(8S)-8-(chloromethyl)-4-hydroxy-1-methyl-7,8-dihydro-3H-pyrrolo[3,2-e]indole-6-carbonyl]-1H-indol-5-yl]urea

分子式

C43H36Cl2N8O5

熔点

密度

1.604g/cm3

分子量

815.703

沸点

溶解度

信号词

危险品标志

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化合物简介

As members of the cyclopropylpyrroloindole family, Adozelesin and Bizelesin cause genomic DNA lesions by alkylating DNA. Adozelesin induces single-strand DNA lesions, whereas Bizelesin induces both single-strand lesions and double-strand DNA cross-links. Thus, despite similar abilities to alkylate DNA, the chemotherapeutic agents Adozelesin and Bizelesin caused a decrease in HCT116 tumor cell proliferation by different pathways (i.e., Adozelesin induced apoptosis, and Bizelesin induced senescence).

基本信息

中文名称

比折来新

英文名称

1,3-bis[2-[(8S)-8-(chloromethyl)-4-hydroxy-1-methyl-7,8-dihydro-3H-pyrrolo[3,2-e]indole-6-carbonyl]-1H-indol-5-yl]urea

中文别名

英文别名

Benzo(1,2-b:4,3-b\')dipyrrol-4-ol,6,6\'-(carbonylbis(imino-1H-indole-5,2-diylcarbonyl))bis(8-(chloromethyl)-3,6,7,8-tetrahydro-1-methyl-,(S-(R*,R*))、U-77,779、BIZELESIN、Bizelesin (USAN/INN)

CAS号

129655-21-6

分子式

C43H36Cl2N8O5

分子量

815.703

精确质量

814.219

PSA

185.37

LOGP

9.5254

编号系统

UNII

L0O9OBI87E

物化性质

密度

1.604g/cm3

折射率

1.856

合成路线

(S)-1-(chloromethyl)-1,6-dihydro-5-hydroxy-8-methylbenzo[1,2-b:4,3-b']dipyrrole hydrochloride

(S)-1-(chloromethyl)-1,6-dihydro-5-hydroxy-8-methylbenzo[1,2-b:4,3-b']dipyrrole hydrochloride

1H-Indole-2-carboxylic acid, 5,5'-(carbonyldiimino)bis-

1H-Indole-2-carboxylic acid, 5,5'-(carbonyldiimino)bis-

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上游原料

共找到9个上游原料 >

(S)-6-tert-butyl 1-methyl 8-(acetoxymethyl)-4-(benzyloxy)-7,8-dihydropyrrolo[3,2-e]indole-1,6(3H)-dicarboxylate

(S)-6-tert-butyl 1-methyl 8-(acetoxymethyl)-4-(benzyloxy)-7,8-dihydropyrrolo[3,2-e]indole-1,6(3H)-dicarboxylate

(S)-1,6-dihydro-1-(hydroxymethyl)-8-methyl-5-(phenylmethoxy)-benzo[1,2-b:4,3-b']dipyrrole-3(2H)-carboxylic acid 1,1-dimethylethyl ester

(S)-1,6-dihydro-1-(hydroxymethyl)-8-methyl-5-(phenylmethoxy)-benzo[1,2-b:4,3-b']dipyrrole-3(2H)-carboxylic acid 1,1-dimethylethyl ester

(1S)-3-[(tert-butyloxy)carbonyl]-1-(chloromethyl)-5-hydroxy-8-methyl-1,2-dihydro-3H-pyrrolo[3,2-e]indole

(1S)-3-[(tert-butyloxy)carbonyl]-1-(chloromethyl)-5-hydroxy-8-methyl-1,2-dihydro-3H-pyrrolo[3,2-e]indole

(S)-3-Acetoxymethyl-6-benzyloxy-5-((E)-2-methoxycarbonyl-vinylamino)-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester

(S)-3-Acetoxymethyl-6-benzyloxy-5-((E)-2-methoxycarbonyl-vinylamino)-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester

(S)-1-(chloromethyl)-1,6-dihydro-5-hydroxy-8-methylbenzo[1,2-b:4,3-b']dipyrrole hydrochloride

(S)-1-(chloromethyl)-1,6-dihydro-5-hydroxy-8-methylbenzo[1,2-b:4,3-b']dipyrrole hydrochloride

1H-Indole-2-carboxylic acid, 5,5'-(carbonyldiimino)bis-

1H-Indole-2-carboxylic acid, 5,5'-(carbonyldiimino)bis-

上游原料

(S)-6-tert-butyl 1-methyl 8-(acetoxymethyl)-4-(benzyloxy)-7,8-dihydropyrrolo[3,2-e]indole-1,6(3H)-dicarboxylate (S)-1,6-dihydro-1-(hydroxymethyl)-8-methyl-5-(phenylmethoxy)-benzo[1,2-b:4,3-b']dipyrrole-3(2H)-carboxylic acid 1,1-dimethylethyl ester (1S)-3-[(tert-butyloxy)carbonyl]-1-(chloromethyl)-5-hydroxy-8-methyl-1,2-dihydro-3H-pyrrolo[3,2-e]indole (S)-3-Acetoxymethyl-6-benzyloxy-5-((E)-2-methoxycarbonyl-vinylamino)-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester (S)-1-(chloromethyl)-1,6-dihydro-5-hydroxy-8-methylbenzo[1,2-b:4,3-b']dipyrrole hydrochloride 5,5'-(carbonyldiimino)bis-1H-indole-2-carboxylic acid diethyl ester 5-氨基吲哚-2-甲酸乙酯 (S)-1-(chloromethyl)-1,6-dihydro-8-methyl-5-(phenylmethoxy)-benzo[1,2-b:4,3-b']dipyrrole-3(2H)-carboxylic acid 1,1-dimethylethyl ester