百科

4-氨基-1-[(2R,3E,4S,5R)-3-(氟亚甲基)-4-羟基-5-(羟基甲基)四氢呋喃-2-基]嘧啶-2-酮

CAS号：130306-02-4

英文名：4-amino-1-[(2R,3E,4S,5R)-3-(fluoromethylidene)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

分子式

C10H12FN3O4

熔点

密度

分子量

257.218

沸点

590.1ºC at 760 mmHg

溶解度

信号词

危险品标志

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化合物简介

Tezacitabine is a ribonucleotide reductase inhibitor. It is a synthetic purine nucleoside analogue with potential antineoplastic activity. It is used for DNA synthetic.

基本信息

中文名称

4-氨基-1-[(2R,3E,4S,5R)-3-(氟亚甲基)-4-羟基-5-(羟基甲基)四氢呋喃-2-基]嘧啶-2-酮

英文名称

4-amino-1-[(2R,3E,4S,5R)-3-(fluoromethylidene)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

中文别名

英文别名

Fmdc cpd、tezaciabine、Tezacitabine、Mdl 101,731、FMdC

CAS号

130306-02-4

分子式

C10H12FN3O4

分子量

257.218

精确质量

257.081

PSA

110.6

LOGP

-0.4893

编号系统

UNII

7607Y95N9S

物化性质

沸点

590.1ºC at 760 mmHg

闪点

310.7ºC

合成路线

149008-04-8

4-amino-1-((6aR,8R,9aS,Z)-9-(fluoro(tributylstannyl)methylene)-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)pyrimidin-2(1H)-one

130306-02-4

4-氨基-1-[(2R,3E,4S,5R)-3-(氟亚甲基)-4-羟基-5-(羟基甲基)四氢呋喃-2-基]嘧啶-2-酮

上游原料

共找到5个上游原料 >

132619-21-7

(Z)-1-(2-deoxy-2-(fluoro(phenylsulfonyl)methylene)-3,5-O-(1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl)-β-D-erythro-pentofuranosyl)-4-ethoxy-2(1H)-pyrimidinone

113648-22-9

4-ethoxy-1-[3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-erythro-2-pentulofuranosyl]-2(1H)-pyrimidinone

135789-90-1

(E)-1-[2-deoxy-2-(fluoromethylene)-3,5-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]-β-D-erythro-pentofuranosyl]cytosine

135789-88-7

(Z)-1-[2-deoxy-2-[fluoro(tributylstannyl)methylene]-3,5-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]-β-D-erythro-pentofuranosyl]-4-ethoxy-2(1H)-pyrimidinone

149008-04-8

4-amino-1-((6aR,8R,9aS,Z)-9-(fluoro(tributylstannyl)methylene)-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)pyrimidin-2(1H)-one

上游原料

(Z)-1-(2-deoxy-2-(fluoro(phenylsulfonyl)methylene)-3,5-O-(1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl)-β-D-erythro-pentofuranosyl)-4-ethoxy-2(1H)-pyrimidinone 4-ethoxy-1-[3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-erythro-2-pentulofuranosyl]-2(1H)-pyrimidinone (E)-1-[2-deoxy-2-(fluoromethylene)-3,5-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]-β-D-erythro-pentofuranosyl]cytosine (Z)-1-[2-deoxy-2-[fluoro(tributylstannyl)methylene]-3,5-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]-β-D-erythro-pentofuranosyl]-4-ethoxy-2(1H)-pyrimidinone 4-amino-1-((6aR,8R,9aS,Z)-9-(fluoro(tributylstannyl)methylene)-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)pyrimidin-2(1H)-one