百科

2,5-二(羟基甲基)-3,4-吡咯烷二醇

2,5-二(羟基甲基)-3,4-吡咯烷二醇

CAS号：132295-44-4

英文名：2,5-Anhydro-2,5-imino-D-glucitol

分子式

C6H13NO4

熔点

139-142.5ºC

密度

1.408g/cm3

分子量

163.172

沸点

395.9ºC at 760 mmHg

溶解度

信号词

危险品标志

若想填写更详细的询价信息，请点击进入询价页面

点我

化合物简介

Many pyrrolidines are powerful inhibitors of glycohydrolases, enzymes responsible for cleavage of glycosidic bonds, glycoprotein processing and the gastrointestinal breakdown of dietary carbohydrates. These compounds are charged at physiological pH and are believed to associate with acidic amino acids at the active site. Inhibition of glycohydrolases could be of therapeutic value for the treatment of viral infections, cancer, diabetes, and obesity.

基本信息

中文名称

2,5-二(羟基甲基)-3,4-吡咯烷二醇

英文名称

2,5-Anhydro-2,5-imino-D-glucitol

中文别名

英文别名

(2R,4R,5S)-2,5-bis(hydroxymethyl)pyrrolidine-3,4-diol

CAS号

132295-44-4

分子式

C6H13NO4

分子量

163.172

精确质量

163.084

PSA

92.95

LOGP

-2.638

物化性质

外观与性状

白色结晶固体

密度

1.408g/cm3

沸点

395.9ºC at 760 mmHg

熔点

139-142.5ºC

闪点

221.9ºC

折射率

1.559

蒸汽压

6.55E-08mmHg at 25°C

合成路线

5-azido-5-deoxy-L-sorbose

5-azido-5-deoxy-L-sorbose

2,5-二(羟基甲基)-3,4-吡咯烷二醇

2,5-二(羟基甲基)-3,4-吡咯烷二醇

2,5-二(羟基甲基)-3,4-吡咯烷二醇

2,5-二(羟基甲基)-3,4-吡咯烷二醇

上游原料

共找到52个上游原料 >

(3S,4R,5S)-3-azido-5-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-hydroxydihydrofuran-2(3H)-one

(3S,4R,5S)-3-azido-5-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-hydroxydihydrofuran-2(3H)-one

(3S,4R,5S)-3-Azido-5-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-hydroxy-dihydro-furan-2-one

(3S,4R,5S)-3-Azido-5-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-hydroxy-dihydro-furan-2-one

methyl (2R,3R,4R,5R)-3-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)-4-hydroxypyrrolidine-2-carboxylate

methyl (2R,3R,4R,5R)-3-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)-4-hydroxypyrrolidine-2-carboxylate

3-O-(2-bromomethyl)benzyl-1,2:4,5-di-O-isopropylidene-β-D-fructopyranose

3-O-(2-bromomethyl)benzyl-1,2:4,5-di-O-isopropylidene-β-D-fructopyranose

4-O-benzoyl-3-O-benzyl-1,2-O-isopropylidene-β-D-fructopyranose

4-O-benzoyl-3-O-benzyl-1,2-O-isopropylidene-β-D-fructopyranose

(3S,4R,5R)-3-Azido-4-(tert-butyl-dimethyl-silanyloxy)-5-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-dihydro-furan-2-one

(3S,4R,5R)-3-Azido-4-(tert-butyl-dimethyl-silanyloxy)-5-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-dihydro-furan-2-one

上游原料

(3S,4R,5S)-3-azido-5-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-hydroxydihydrofuran-2(3H)-one (3S,4R,5S)-3-Azido-5-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-hydroxy-dihydro-furan-2-one methyl (2R,3R,4R,5R)-3-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)-4-hydroxypyrrolidine-2-carboxylate 3-O-(2-bromomethyl)benzyl-1,2:4,5-di-O-isopropylidene-β-D-fructopyranose 4-O-benzoyl-3-O-benzyl-1,2-O-isopropylidene-β-D-fructopyranose (3S,4R,5R)-3-Azido-4-(tert-butyl-dimethyl-silanyloxy)-5-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-dihydro-furan-2-one (2S,3R,4R,5R)-2-(hydroxymethyl)-4-[dimethyl(phenyl)silyl]-5-{[dimethyl(phenyl)silyl]methyl}-1-tosylpyrrolidin-3-ol 3,4-di-O-benzyl-6-[(tert-butyloxycarbonyl)amino]-2,5-[(1-oxycarbonyl)imino]-2,5,6-trideoxy-D-glucitol (3R,4R,5R)-3-Azido-4-(tert-butyl-dimethyl-silanyloxy)-5-[(S)-2-(tert-butyl-dimethyl-silanyloxy)-1-hydroxy-ethyl]-dihydro-furan-2-one (3R,4R,5R)-3-Azido-4-(tert-butyl-dimethyl-silanyloxy)-5-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-dihydro-furan-2-one 3,4-di-O-benzyl-2,5-[(1-oxycarbonyl)imino]-2,5-dideoxy-D-glucitol methyl 2-azido-2-deoxy-3,4:5,6-di-O-isopropylidene-D-mannonate (1R,4S,6S,7R)-7-((tert-butyldimethylsilyl)oxy)-6-(((tert-butyldimethylsilyl)oxy)methyl)-2-oxa-5-azabicyclo[2.2.1]heptan-3-one (2S,2'S)-<(1R,2R)-1,2-dibenzyloxy-ethan-diyl>bis(1-tert-butoxycarbonyl)-aziridine ((2R,3S,4R,5S)-5-azido-2,3,4-trihydroxytetrahydro-2H-pyran-2-yl)methyl dihydrogen phosphate 3,4-di-O-benzyl-1,2-O-isopropylidene-5-O-methanesulfonyl-β-D-fructopyranose (S)-1-((2S,3R,4R)-4-amino-3-((tert-butyldimethylsilyl)oxy)-5-oxotetrahydrofuran-2-yl)-2-((tert-butyldimethylsilyl)oxy)ethyl trifluoromethanesulfonate (2S,3R,4R,5R)-4-(benzoyloxy)-3-(benzyloxy)-1-(benzyloxycarbonyl)-2-[(tert-butyldiphenylsilyloxy)methyl]-5-(hydroxymethyl)pyrrolidine 5,6-O-isopropylidene-2-O-trifluoromethylsulfonyl-D-mannono-1,4-lactone 5-azido-3,4-di-O-benzyl-5-deoxy-α-L-sorbopyranose 2-benzyloxycarbonylamino-2-deoxy-3,4-O-isopropylidene-5-O-methanesulfonyloxy-6-O-(tert-butyldimethylsilyl)oxy-D-glucitol (2S,3R,4R,5R)-N-benzyl-3,4-dibenzyloxy-5-[(benzyloxy)methyl]-2-hydroxymethyl-pyrrolidine (3R,4R,5S)-3-azido-5-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-hydroxydihydrofuran-2(3H)-one (S)-1-((2S,3R,4R)-4-azido-3-((tert-butyldimethylsilyl)oxy)-5-oxotetrahydrofuran-2-yl)-2-((tert-butyldimethylsilyl)oxy)ethyl trifluoromethanesulfonate 3-O-(2-bromomethyl)benzyl-1,2-O-isopropylidene-β-D-fructopyranose 10-(benzyloxy)-2,2-dimethyl-1,3,6-trioxaspiro(4,5)decane-8,9-diol 5-azido-4-O-benzoyl-3-O-benzyl-5-deoxy-β-D-fructopyranose tert-butyl (1S,2S,4R,5R)-2-(acetoxymethyl)-4-(hydroxymethyl)-6-oxa-3-azabicyclo[3.1.0]hexane-3-carboxylate (3S,4S,5S)-5-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-hydroxy-2-oxotetrahydrofuran-3-yl trifluoromethanesulfonate 4-O-benzoyl-3-O-benzyl-5-deoxy-5-iodo-1,2-O-isopropylidene-α-L-sorbopyranose (3S,4R,5S)-3-Azido-5-((R)-1,2-dihydroxy-ethyl)-4-hydroxy-dihydro-furan-2-one 5-azido-3-O-benzoyl-4-O-benzyl-5-deoxy-1,2-O-isopropylidene-α-L-sorbopyranose 3,4-di-O-benzyl-2,5-[(6-oxycarbonyl)imino]-2,5-dideoxy-D-glucitol 5-酮果糖 5-azido-4-O-benzyl-5-deoxy-1,2-O-isopropylidene-α-L-sorbopyranose (R)-1-((2S,3R,4S)-4-azido-3-((tert-butyldimethylsilyl)oxy)-5-oxotetrahydrofuran-2-yl)-2-((tert-butyldimethylsilyl)oxy)ethyl trifluoromethanesulfonate 5-azido-3,4-di-O-benzyl-5-deoxy-1,2-O-isopropylidene-α-L-sorbopyranose (3R,4R,5R)-3-azido-4-((tert-butyldimethylsilyl)oxy)-5-((S)-1,2-dihydroxyethyl)dihydrofuran-2(3H)-one (3S,4R,5R)-3-Azido-4-(tert-butyl-dimethyl-silanyloxy)-5-((R)-1,2-dihydroxy-ethyl)-dihydro-furan-2-one FRUCTOSE, (D) (2S,3R,4R)-2,5-二(羟基甲基)-3,4-二氢-2H-吡咯-3,4-二醇 (3S,4R,5R)-3-Azido-4-(tert-butyl-dimethyl-silanyloxy)-5-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-1-hydroxy-ethyl]-dihydro-furan-2-one 5-azido-5-deoxy-L-sorbose 2,3,5-三-O-(苯基甲基)-D-呋喃阿拉伯糖 1,2:4,5-二-O-异亚丙基-BETA-D-吡喃果糖 1,2-O-isopropylidene-3,4-di-O-benzyl-β-D-fructopyranose