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[(2S,4S,5R)-4-氟-5-嘌呤-9-基四氢呋喃-2-基]甲醇

[(2S,4S,5R)-4-氟-5-嘌呤-9-基四氢呋喃-2-基]甲醇

CAS号：132722-90-8

英文名：[(2S,4S,5R)-4-fluoro-5-purin-9-yloxolan-2-yl]methanol

分子式

C10H11FN4O2

熔点

密度

1.7g/cm3

分子量

238.218

沸点

460.1ºC at 760mmHg

溶解度

信号词

危险品标志

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基本信息

中文名称

[(2S,4S,5R)-4-氟-5-嘌呤-9-基四氢呋喃-2-基]甲醇

英文名称

[(2S,4S,5R)-4-fluoro-5-purin-9-yloxolan-2-yl]methanol

中文别名

英文别名

2\'-F-Ara-ddp

CAS号

132722-90-8

分子式

C10H11FN4O2

分子量

238.218

精确质量

238.087

PSA

73.06

LOGP

0.4442

物化性质

密度

1.7g/cm3

沸点

460.1ºC at 760mmHg

闪点

232.1ºC

折射率

1.737

蒸汽压

2.92E-09mmHg at 25°C

合成路线

9-[5'-O-(tert-butyldimethylsilyl)-2',3'-dideoxy-2'-fluoro-β-D-arabinofuranosyl]-9H-purine

9-[5'-O-(tert-butyldimethylsilyl)-2',3'-dideoxy-2'-fluoro-β-D-arabinofuranosyl]-9H-purine

[(2S,4S,5R)-4-氟-5-嘌呤-9-基四氢呋喃-2-基]甲醇

[(2S,4S,5R)-4-氟-5-嘌呤-9-基四氢呋喃-2-基]甲醇

上游原料

共找到6个上游原料 >

[(3aR,5S,6aR)-2,2-dimethyltetrhydrofuro[2,3-d][1,3]dioxol-5-yl]methyl benzoate

[(3aR,5S,6aR)-2,2-dimethyltetrhydrofuro[2,3-d][1,3]dioxol-5-yl]methyl benzoate

9-[5'-O-(tert-butyldimethylsilyl)-2',3'-dideoxy-2'-fluoro-β-D-arabinofuranosyl]-9H-purine

9-[5'-O-(tert-butyldimethylsilyl)-2',3'-dideoxy-2'-fluoro-β-D-arabinofuranosyl]-9H-purine

9-[5'-O-(tert-butyldimethylsilyl)-2'-deoxy-2'-fluoro-β-D-arabinofuranosyl]-9H-purine

9-[5'-O-(tert-butyldimethylsilyl)-2'-deoxy-2'-fluoro-β-D-arabinofuranosyl]-9H-purine

(6-chloropurin-9-yl)-trimethylsilane

(6-chloropurin-9-yl)-trimethylsilane

5-O-benzoyl-2,3-dideoxy-1,2-difluoro-α-D-arabinofuranose

5-O-benzoyl-2,3-dideoxy-1,2-difluoro-α-D-arabinofuranose

((2S,4S,5R)-5-(6-chloro-9H-purin-9-yl)-4-fluorotetrahydrofuran-2-yl)methyl benzoate

((2S,4S,5R)-5-(6-chloro-9H-purin-9-yl)-4-fluorotetrahydrofuran-2-yl)methyl benzoate

上游原料

[(3aR,5S,6aR)-2,2-dimethyltetrhydrofuro[2,3-d][1,3]dioxol-5-yl]methyl benzoate 9-[5'-O-(tert-butyldimethylsilyl)-2',3'-dideoxy-2'-fluoro-β-D-arabinofuranosyl]-9H-purine 9-[5'-O-(tert-butyldimethylsilyl)-2'-deoxy-2'-fluoro-β-D-arabinofuranosyl]-9H-purine (6-chloropurin-9-yl)-trimethylsilane 5-O-benzoyl-2,3-dideoxy-1,2-difluoro-α-D-arabinofuranose ((2S,4S,5R)-5-(6-chloro-9H-purin-9-yl)-4-fluorotetrahydrofuran-2-yl)methyl benzoate