化合物简介
Trichlormethiazide (INN, currently being sold under the brand names of Achletin, Diu-Hydrin and Triflumen) is a diuretic with properties similar to those of hydrochlorothiazide. It is usually administered for the treatment of oedema (including that which is associated with heart failure, hepatic cirrhosis and corticosteroid therapy) and hypertension. In veterinary medicine, trichlormethiazide can be combined with dexamethasone to be used on horses with mild swelling of distal limbs and general bruising.
基本信息
中文名称
三氯噻嗪
英文名称
Trichlormethiazide
中文别名
6-氯-3-(二氯甲基)-3,4-二氢-7-氨基磺酰基-1,2,4-苯并噻二嗪-1,1-二氧化物
英文别名
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(dichloromethyl)-3,4-dihydro-, 1,1-dioxide、6-chloro-3-(dichloromethyl)-1,1-dioxo-3,4-dihydro-2H-1λ<sup>6</sup>,2,4-benzothiadiazine-7-sulfonamide、3-Dichloromethyl-6-chloro-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide、Trichloromethiazide、6-Chloro-3-dichloromethyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-Dioxide、Achletin,Diu-Hydrin,Triflumen
CAS号
133-67-5
分子式
C8H8Cl3N3O4S2
分子量
380.656
精确质量
378.902
PSA
135.12
LOGP
4.1497
编号系统
MDL号
MFCD00057315
RTECS号
DK8925000
EINECS号
205-118-8
PubChem号
24899924
物化性质
密度
1.748g/cm3
沸点
631.3ºC at 760mmHg
熔点
248-250ºC
闪点
335.6ºC
折射率
1.625
蒸汽压
7.62E-16mmHg at 25°C
安全信息
RTECS号
DK8925000
安全说明
S36
WGK Germany
2
危险类别码
R42/43
海关编码
2935009090
危险品标志
Xn
生产方法及用途
用途
用作利尿药。