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PF-4136309

PF-4136309

CAS号：1341224-83-6

英文名：PF-4136309

分子式

C29H31F3N6O3

熔点

密度

分子量

568.59

沸点

溶解度

信号词

危险品标志

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基本信息

中文名称

PF-4136309

英文名称

PF-4136309

中文别名

英文别名

INCB 8761(PF-4136309)、INCB8761(PF-4136309)、(S)-N-[2-(3-{trans-4-hydroxy-4-[5-(pyrimidin-2-yl)pyridin-2-yl]cyclohexylamino}pyrrolidin-1-yl)-2-oxoethyl]-3-(trifluoromethyl)benzamide、(S)-N-(2-(3-((4-hydroxy-4-(5-(pyrimidin-2-yl)pyridin-2-yl)cyclohexyl)amino)pyrrolidin-1-yl)-2-oxoethyl)-3-(trifluoromethyl)benzamide

CAS号

1341224-83-6

分子式

C29H31F3N6O3

分子量

568.59

精确质量

568.241

PSA

120.34

LOGP

4.0278

物化性质

外观与性状

米色或淡黄色固体

合成路线

4-hydroxy-4-(5-pyrimidin-2-ylpyridin-2-yl)cyclohexanone

4-hydroxy-4-(5-pyrimidin-2-ylpyridin-2-yl)cyclohexanone

(S)-N-{2-[3-aminopyrrolidin-1-yl]-2-oxoethyl}-3-(trifluoromethyl)benzamide hydrochloride

(S)-N-{2-[3-aminopyrrolidin-1-yl]-2-oxoethyl}-3-(trifluoromethyl)benzamide hydrochloride

PF-4136309

上游原料

共找到7个上游原料 >

8-(5-pyrimidin-2-ylpyridin-2-yl)-1,4-dioxaspiro[4.5]decan-8-ol

8-(5-pyrimidin-2-ylpyridin-2-yl)-1,4-dioxaspiro[4.5]decan-8-ol

2,5-二溴吡啶

2,5-二溴吡啶

1,4-环己二酮单乙二醇缩酮

1,4-环己二酮单乙二醇缩酮

8-(5-bromopyridin-2-yl)-1,4-dioxaspiro[4.5]decan-8-ol

8-(5-bromopyridin-2-yl)-1,4-dioxaspiro[4.5]decan-8-ol

间三氟甲基马尿酸

间三氟甲基马尿酸

4-hydroxy-4-(5-pyrimidin-2-ylpyridin-2-yl)cyclohexanone

4-hydroxy-4-(5-pyrimidin-2-ylpyridin-2-yl)cyclohexanone

上游原料

8-(5-pyrimidin-2-ylpyridin-2-yl)-1,4-dioxaspiro[4.5]decan-8-ol 2,5-二溴吡啶 1,4-环己二酮单乙二醇缩酮 8-(5-bromopyridin-2-yl)-1,4-dioxaspiro[4.5]decan-8-ol 间三氟甲基马尿酸 4-hydroxy-4-(5-pyrimidin-2-ylpyridin-2-yl)cyclohexanone (S)-N-{2-[3-aminopyrrolidin-1-yl]-2-oxoethyl}-3-(trifluoromethyl)benzamide hydrochloride