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GSK 126

GSK 126

CAS号：1346574-57-9

英文名：1-[(2S)-butan-2-yl]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-methyl-6-(6-piperazin-1-ylpyridin-3-yl)indole-4-carboxamide

分子式

C31H38N6O2

熔点

密度

分子量

526.672

沸点

溶解度

信号词

危险品标志

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化合物简介

GSK126 is a potent and highly selective S-adenosyl-methionine-competitive small molecule inhibitor of EZH2 methyltransferase enzyme activity. The inhibition activity of GSK126 on EZH2 activity may provide a promising treatment for EZH2 mutant lymphoma.

基本信息

中文名称

GSK 126

英文名称

1-[(2S)-butan-2-yl]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-methyl-6-(6-piperazin-1-ylpyridin-3-yl)indole-4-carboxamide

中文别名

英文别名

(S)-1-sec-butyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide、CS-1401、N-[(4,6-dimethyl-2-oxo-1,2-dihydro-3-pyridinyl)methyl]-3-methyl-1-[(1S)-1-methylpropyl]-6-[6-(1-piperazinyl)-3-pyridinyl]-1H-indole-4-carboxamide、GSK126||GSK-126|GSK 126、GSK126、QC-9703

CAS号

1346574-57-9

分子式

C31H38N6O2

分子量

526.672

精确质量

526.306

PSA

98.8

LOGP

6.0083

编号系统

UNII

W4OGW9QZ97

合成路线

2-(哌嗪-1-基)吡啶-5-硼酸频那醇酯

2-(哌嗪-1-基)吡啶-5-硼酸频那醇酯

(S)-6-bromo-1-(sec-butyl)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-methyl-1H-indole-4-carboxamide

(S)-6-bromo-1-(sec-butyl)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-methyl-1H-indole-4-carboxamide

GSK 126

上游原料

共找到5个上游原料 >

(S)-6-bromo-1-(sec-butyl)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-methyl-1H-indole-4-carboxamide

(S)-6-bromo-1-(sec-butyl)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-methyl-1H-indole-4-carboxamide

6-bromo-1-(sec-butyl)-3-methyl-1H-indole-4-carboxylic acid

6-bromo-1-(sec-butyl)-3-methyl-1H-indole-4-carboxylic acid

2-(哌嗪-1-基)吡啶-5-硼酸频那醇酯

2-(哌嗪-1-基)吡啶-5-硼酸频那醇酯

6-bromo-N-[(4,6-dimethyl-2-oxo-1,2-dihydro-3-pyridinyl)methyl]-3-methyl-1-(1-methylpropyl)-1H-indole-4-carboxamide

6-bromo-N-[(4,6-dimethyl-2-oxo-1,2-dihydro-3-pyridinyl)methyl]-3-methyl-1-(1-methylpropyl)-1H-indole-4-carboxamide

3-(氨基甲基)-4,6-二甲基-2(1H)-吡啶酮(9ci)

3-(氨基甲基)-4,6-二甲基-2(1H)-吡啶酮(9ci)

上游原料

(S)-6-bromo-1-(sec-butyl)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-methyl-1H-indole-4-carboxamide 6-bromo-1-(sec-butyl)-3-methyl-1H-indole-4-carboxylic acid 2-(哌嗪-1-基)吡啶-5-硼酸频那醇酯 6-bromo-N-[(4,6-dimethyl-2-oxo-1,2-dihydro-3-pyridinyl)methyl]-3-methyl-1-(1-methylpropyl)-1H-indole-4-carboxamide 3-(氨基甲基)-4,6-二甲基-2(1H)-吡啶酮(9ci)