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{(1R,2R)-2-[(E)-(S)-6-(tert-Butyl-dimethyl-silanyloxy)-hept-1-enyl]-4-oxo-cyclopentyl}-acetonitrile

{(1R,2R)-2-[(E)-(S)-6-(tert-Butyl-dimethyl-silanyloxy)-hept-1-enyl]-4-oxo-cyclopentyl}-acetonitrile

CAS号：135272-95-6

英文名：{(1R,2R)-2-[(E)-(S)-6-(tert-Butyl-dimethyl-silanyloxy)-hept-1-enyl]-4-oxo-cyclopentyl}-acetonitrile

分子式：C20H35NO2Si

分子量：349.583

合成路线

(+)-4-cyanomethylcyclopent-2-en-1-one

(+)-4-cyanomethylcyclopent-2-en-1-one

(S,E)-(6-((tert-butyldimethylsilyl)oxy)hept-1-en-1-yl)(hex-1-yn-1-yl)copper

(S,E)-(6-((tert-butyldimethylsilyl)oxy)hept-1-en-1-yl)(hex-1-yn-1-yl)copper

{(1R,2R)-2-[(E)-(S)-6-(tert-Butyl-dimethyl-silanyloxy)-hept-1-enyl]-4-oxo-cyclopentyl}-acetonitrile

{(1R,2R)-2-[(E)-(S)-6-(tert-Butyl-dimethyl-silanyloxy)-hept-1-enyl]-4-oxo-cyclopentyl}-acetonitrile

(R)-4-acetoxycyclopent-2-en-1-one

(R)-4-acetoxycyclopent-2-en-1-one

{(1R,2R)-2-[(E)-(S)-6-(tert-Butyl-dimethyl-silanyloxy)-hept-1-enyl]-4-oxo-cyclopentyl}-acetonitrile

{(1R,2R)-2-[(E)-(S)-6-(tert-Butyl-dimethyl-silanyloxy)-hept-1-enyl]-4-oxo-cyclopentyl}-acetonitrile

上游原料

(+)-4-cyanomethylcyclopent-2-en-1-one (R)-4-acetoxycyclopent-2-en-1-one (S,E)-(6-((tert-butyldimethylsilyl)oxy)hept-1-en-1-yl)(hex-1-yn-1-yl)copper

下游产品

{(1S,2R,4R)-2-[(E)-(S)-6-(tert-Butyl-dimethyl-silanyloxy)-hept-1-enyl]-4-methoxymethoxy-cyclopentyl}-acetaldehyde {(1R,2R,4R)-2-[(E)-(S)-6-(tert-Butyl-dimethyl-silanyloxy)-hept-1-enyl]-4-methoxymethoxy-cyclopentyl}-acetonitrile (+)-epibrefeldin A (E)-4-{(1R,2S,4S)-2-[(E)-(S)-6-(tert-Butyl-dimethyl-silanyloxy)-hept-1-enyl]-4-methoxymethoxy-cyclopentyl}-4-(tetrahydro-pyran-2-yloxy)-but-2-enoic acid ethyl ester (E)-4-{(1R,2S,4S)-2-[(E)-(S)-6-(tert-Butyl-dimethyl-silanyloxy)-hept-1-enyl]-4-methoxymethoxy-cyclopentyl}-4-hydroxy-but-2-enoic acid ethyl ester