百科

tert-butyl (S)-(1-(2-(1-(5-chloro-2-(methylsulfonamido)benzoyl)piperidin-2-yl)-5-(3-hydroxyazetidin-1-yl)pyrazolo[1,5-a]pyrimidin-7-yl)azetidin-3-yl)carbamate

tert-butyl (S)-(1-(2-(1-(5-chloro-2-(methylsulfonamido)benzoyl)piperidin-2-yl)-5-(3-hydroxyazetidin-1-yl)pyrazolo[1,5-a]pyrimidin-7-yl)azetidin-3-yl)carbamate

CAS号：1353629-10-3

英文名：tert-butyl (S)-(1-(2-(1-(5-chloro-2-(methylsulfonamido)benzoyl)piperidin-2-yl)-5-(3-hydroxyazetidin-1-yl)pyrazolo[1,5-a]pyrimidin-7-yl)azetidin-3-yl)carbamate

分子式：C30H39ClN8O6S

分子量：675.199

合成路线

(S)-5,7-dichloro-2-(piperidin-2-yl)pyrazolo[1,5-a]pyrimidine hydrochloride

(S)-5,7-dichloro-2-(piperidin-2-yl)pyrazolo[1,5-a]pyrimidine hydrochloride

tert-butyl (S)-(1-(2-(1-(5-chloro-2-(methylsulfonamido)benzoyl)piperidin-2-yl)-5-(3-hydroxyazetidin-1-yl)pyrazolo[1,5-a]pyrimidin-7-yl)azetidin-3-yl)carbamate

tert-butyl (S)-(1-(2-(1-(5-chloro-2-(methylsulfonamido)benzoyl)piperidin-2-yl)-5-(3-hydroxyazetidin-1-yl)pyrazolo[1,5-a]pyrimidin-7-yl)azetidin-3-yl)carbamate

(S)-tert-butyl 2-(5-Amino-1H-pyrazol-3-yl)piperidine-1-carboxylate

(S)-tert-butyl 2-(5-Amino-1H-pyrazol-3-yl)piperidine-1-carboxylate

tert-butyl (S)-(1-(2-(1-(5-chloro-2-(methylsulfonamido)benzoyl)piperidin-2-yl)-5-(3-hydroxyazetidin-1-yl)pyrazolo[1,5-a]pyrimidin-7-yl)azetidin-3-yl)carbamate

tert-butyl (S)-(1-(2-(1-(5-chloro-2-(methylsulfonamido)benzoyl)piperidin-2-yl)-5-(3-hydroxyazetidin-1-yl)pyrazolo[1,5-a]pyrimidin-7-yl)azetidin-3-yl)carbamate

(S)-N-(4-chloro-2-(2-(5,7-dichloropyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide

(S)-N-(4-chloro-2-(2-(5,7-dichloropyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide

tert-butyl (S)-(1-(2-(1-(5-chloro-2-(methylsulfonamido)benzoyl)piperidin-2-yl)-5-(3-hydroxyazetidin-1-yl)pyrazolo[1,5-a]pyrimidin-7-yl)azetidin-3-yl)carbamate

tert-butyl (S)-(1-(2-(1-(5-chloro-2-(methylsulfonamido)benzoyl)piperidin-2-yl)-5-(3-hydroxyazetidin-1-yl)pyrazolo[1,5-a]pyrimidin-7-yl)azetidin-3-yl)carbamate

tert-butyl (S)-2-(7-hydroxy-5-oxo-4,5-dihydropyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carboxylate

tert-butyl (S)-2-(7-hydroxy-5-oxo-4,5-dihydropyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carboxylate

tert-butyl (S)-(1-(2-(1-(5-chloro-2-(methylsulfonamido)benzoyl)piperidin-2-yl)-5-(3-hydroxyazetidin-1-yl)pyrazolo[1,5-a]pyrimidin-7-yl)azetidin-3-yl)carbamate

tert-butyl (S)-(1-(2-(1-(5-chloro-2-(methylsulfonamido)benzoyl)piperidin-2-yl)-5-(3-hydroxyazetidin-1-yl)pyrazolo[1,5-a]pyrimidin-7-yl)azetidin-3-yl)carbamate

上游原料

(S)-5,7-dichloro-2-(piperidin-2-yl)pyrazolo[1,5-a]pyrimidine hydrochloride (S)-N-(4-chloro-2-(2-(5,7-dichloropyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide (S)-tert-butyl 2-(5-Amino-1H-pyrazol-3-yl)piperidine-1-carboxylate tert-butyl (S)-2-(7-hydroxy-5-oxo-4,5-dihydropyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carboxylate

下游产品

(S)-N-(2-(2-(7-(3-aminoazetidin-1-yl)-5-(3-hydroxyazetidin-1-yl)pyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)-4-chlorophenyl)methanesulfonamide hydrochloride