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2-(8-Fluoro-2-{2-hydroxymethyl-3-[1-methyl-5-(5-oxetan-3-yl-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazin-2-ylamino)-6-oxo-1,6-dihydro-pyridazin-3-yl]-phenyl}-1-oxo-1,2-dihydro-isoquinolin-6-yl)-2-methyl-propionitrile

2-(8-Fluoro-2-{2-hydroxymethyl-3-[1-methyl-5-(5-oxetan-3-yl-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazin-2-ylamino)-6-oxo-1,6-dihydro-pyridazin-3-yl]-phenyl}-1-oxo-1,2-dihydro-isoquinolin-6-yl)-2-methyl-propionitrile

CAS号：1360055-79-3

英文名：2-(8-Fluoro-2-{2-hydroxymethyl-3-[1-methyl-5-(5-oxetan-3-yl-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazin-2-ylamino)-6-oxo-1,6-dihydro-pyridazin-3-yl]-phenyl}-1-oxo-1,2-dihydro-isoquinolin-6-yl)-2-methyl-propionitrile

分子式

C34H33FN8O4

熔点

密度

分子量

636.675

沸点

溶解度

信号词

危险品标志

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基本信息

中文名称

2-(8-Fluoro-2-{2-hydroxymethyl-3-[1-methyl-5-(5-oxetan-3-yl-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazin-2-ylamino)-6-oxo-1,6-dihydro-pyridazin-3-yl]-phenyl}-1-oxo-1,2-dihydro-isoquinolin-6-yl)-2-methyl-propionitrile

英文名称

2-(8-Fluoro-2-{2-hydroxymethyl-3-[1-methyl-5-(5-oxetan-3-yl-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazin-2-ylamino)-6-oxo-1,6-dihydro-pyridazin-3-yl]-phenyl}-1-oxo-1,2-dihydro-isoquinolin-6-yl)-2-methyl-propionitrile

中文别名

英文别名

2-(8-fluoro-2-{2-hydroxymethyl-3-[1-methyl-5-(5-oxetan-3-yl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl]phenyl}-1-oxo-1,2-dihydroisoquinolin-6-yl)-2-methylpropionitrile

CAS号

1360055-79-3

分子式

C34H33FN8O4

分子量

636.675

精确质量

636.261

PSA

143.23

LOGP

3.34938

合成路线

2-(4-(2-cyanoporopyl-2-yl)-2-fluoro-6-methylphenyl)-3,4,4-trimethyl-4,5-dihydro-1,3-oxazole-3-ium iodide

2-(4-(2-cyanoporopyl-2-yl)-2-fluoro-6-methylphenyl)-3,4,4-trimethyl-4,5-dihydro-1,3-oxazole-3-ium iodide

2-(8-Fluoro-2-{2-hydroxymethyl-3-[1-methyl-5-(5-oxetan-3-yl-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazin-2-ylamino)-6-oxo-1,6-dihydro-pyridazin-3-yl]-phenyl}-1-oxo-1,2-dihydro-isoquinolin-6-yl)-2-methyl-propionitrile

2-(8-Fluoro-2-{2-hydroxymethyl-3-[1-methyl-5-(5-oxetan-3-yl-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazin-2-ylamino)-6-oxo-1,6-dihydro-pyridazin-3-yl]-phenyl}-1-oxo-1,2-dihydro-isoquinolin-6-yl)-2-methyl-propionitrile

上游原料

共找到15个上游原料 >

4-(cyano-dimethyl-methyl)-N-[1-dimethylamino-meth-(E)-ylidene]-2-fluoro-6-methylbenzamide

4-(cyano-dimethyl-methyl)-N-[1-dimethylamino-meth-(E)-ylidene]-2-fluoro-6-methylbenzamide

2-(8-fluoro-1-oxo-1,2-dihydro-isoquinolin-6-yl)-2-methyl-propionitrile

2-(8-fluoro-1-oxo-1,2-dihydro-isoquinolin-6-yl)-2-methyl-propionitrile

4-(cyano-dimethyl-methyl)-2-fluoro-6-methylbenzoic acid

4-(cyano-dimethyl-methyl)-2-fluoro-6-methylbenzoic acid

4-(cyano-dimethyl-methyl)-2-fluoro-6-methylbenzamide

4-(cyano-dimethyl-methyl)-2-fluoro-6-methylbenzamide

methyl 1-(2-bromoethyl)-3-nitro-1H-pyrazole-5-carboxylate

methyl 1-(2-bromoethyl)-3-nitro-1H-pyrazole-5-carboxylate

2-nitro-5-(oxetan-3-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine

2-nitro-5-(oxetan-3-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine

上游原料

4-(cyano-dimethyl-methyl)-N-[1-dimethylamino-meth-(E)-ylidene]-2-fluoro-6-methylbenzamide 2-(8-fluoro-1-oxo-1,2-dihydro-isoquinolin-6-yl)-2-methyl-propionitrile 4-(cyano-dimethyl-methyl)-2-fluoro-6-methylbenzoic acid 4-(cyano-dimethyl-methyl)-2-fluoro-6-methylbenzamide methyl 1-(2-bromoethyl)-3-nitro-1H-pyrazole-5-carboxylate 2-nitro-5-(oxetan-3-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine 5-(oxetan-3-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-ylamine 2-[4-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)-3-fluoro-5-methylphenyl]-2-methylpropionitrile 2-(8-fluoro-2-(2-formyl-3-(1-methyl-5-(5-(oxetan-3-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl)phenyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-2-methylpropanenitrile 6-chloro-2-methyl-4-((5-(oxetan-3-yl)-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazin-2-yl)amino)-2H-pyridazin-3-one 4,4-dimethyl-2-(2,4,6-trifluorophenyl)-4,5-dihydro-1,3-oxazole 2-(2,4-difluoro-6-methylphenyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole 2-(4-(2-cyanoporopyl-2-yl)-2-fluoro-6-methylphenyl)-3,4,4-trimethyl-4,5-dihydro-1,3-oxazole-3-ium iodide 2-[2-(3-bromo-2-formylphenyl)-8-fluoro-1-oxo-1,2-dihydroisoquinolin-6-yl]-2-methylpropionitrile 2,4,6-trifluoro-N-(2-hydroxy-1,1-dimethyl-ethyl)benzamide