化合物简介
KML-29 is an extremely specific monoacylglycerol lipase (MAGL) inhibitor. KML-2 should be useful to distinguish between actions of 2-arachidonoyl glycerol (an endogenous ligand of cannabinoid receptors that is deactivated by MAGL) and anandamide, another endocannabinoid.
基本信息
中文名称
KML-29
英文名称
1,1,1,3,3,3-Hexafluoro-2-propanyl 4-[bis(1,3-benzodioxol-5-yl)(hy droxy)methyl]-1-piperidinecarboxylate
中文别名
英文别名
hexafluoro-2-propyl acrylate、1,1,1,3,3,3-hexafluoroprop-2-yl acrylate、Hexafluoroisopropyl acrylate、1,1,1,3,3,3-hexafluoroisopropylacrylate、1,1,1,3,3,3-hexafluoropropan-2-yl acrylate、Acrylic Acid 1,1,1,3,3,3-Hexafluoroisopropyl Ester
CAS号
1380424-42-9
分子式
C24H21F6NO7
分子量
549.416
精确质量
549.122
PSA
86.69
LOGP
4.6596
合成路线
![bis(benzo[d][1,3]dioxol-5-yl)(piperidin-4-yl)methanol](https://cdn-oss.0elem.com/prod/mob/images/144/1446818-43-4.jpg)
![tert-butyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)-piperidine-1-carboxylate](https://cdn-oss.0elem.com/prod/mob/images/144/1446818-42-3.jpg)
