软骨藻酸

软骨藻酸

CAS号：14277-97-5

英文名：domoic acid

分子式

C15H21NO6

熔点

228ºC

密度

1.273 g/cm3

分子量

311.33

沸点

607.2ºC at 760 mmHg

溶解度

信号词

危险品标志

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化合物简介

Domoic acid (DA) is a kainic acid analog neurotoxin that causes amnesic shellfish poisoning (ASP). It is produced by algae and accumulates in shellfish, sardines, and anchovies. When sea lions, otters, cetaceans, humans etc., then eat contaminated animals poisoning may result. Exposure to the biotoxin affects the brain, causing seizures, and possibly death.

基本信息

中文名称

软骨藻酸

英文名称

domoic acid

中文别名

二甲乙二烯咯三酸、Domoic acid = Domoins辵re

英文别名

Domoic acid、Domoic Acid、Domoic acid,(2S,3S,4R,5\'R)-2-Carboxy-4-(5\'-carboxy-1\'-methyl-1Z,3E-hexadienyl)-3-pyrrolidineaceticacid

CAS号

14277-97-5

分子式

C15H21NO6

分子量

311.33

精确质量

311.137

PSA

123.93

LOGP

1.3019

编号系统

PubChem号

24894006

BRN号

46376

RTECS号

UX9665100

MDL号

MFCD00040640

物化性质

外观与性状

白色至灰白色固体

密度

1.273 g/cm3

沸点

607.2ºC at 760 mmHg

熔点

228ºC

闪点

321ºC

折射率

1.544

储存条件

-20ºC

蒸汽压

2.62E-16mmHg at 25°C

安全信息

危险类别码

R20/21/22

危险品标志

Xn

合成路线

tert-butyl (2S,3S,4S)-4-((S)-1-(1,3-dioxolan-2-yl)ethyl)-3-(2-hydroxyethyl)-2-(hydroxymethyl)pyrrolidine-1-carboxylate

tert-butyl (2S,3S,4S)-4-((S)-1-(1,3-dioxolan-2-yl)ethyl)-3-(2-hydroxyethyl)-2-(hydroxymethyl)pyrrolidine-1-carboxylate

软骨藻酸

上游原料

共找到10个上游原料 >

(2S,3S,4S)-1-tert-butyl 2-methyl 3-(2-methoxy-2-oxoethyl)-4-((R)-1-oxopropan-2-yl)pyrrolidine-1,2-dicarboxylate

(2S,3S,4S)-1-tert-butyl 2-methyl 3-(2-methoxy-2-oxoethyl)-4-((R)-1-oxopropan-2-yl)pyrrolidine-1,2-dicarboxylate

1-(tert-butyl) 2-methyl (2S,3S,4R)-3-(2-methoxy-2-oxoethyl)-4-(4-methoxybut-3-en-2-yl)pyrrolidine-1,2-dicarboxylate

1-(tert-butyl) 2-methyl (2S,3S,4R)-3-(2-methoxy-2-oxoethyl)-4-(4-methoxybut-3-en-2-yl)pyrrolidine-1,2-dicarboxylate

tert-butyl (2S,3S,4S)-4-((S)-1-(1,3-dioxolan-2-yl)ethyl)-3-(2-hydroxyethyl)-2-(hydroxymethyl)pyrrolidine-1-carboxylate

tert-butyl (2S,3S,4S)-4-((S)-1-(1,3-dioxolan-2-yl)ethyl)-3-(2-hydroxyethyl)-2-(hydroxymethyl)pyrrolidine-1-carboxylate

tert-butyl (3S,4S,5S)-3-((S)-1-(1,3-dioxolan-2-yl)ethyl)-5-(((tert-butyldimethylsilyl)oxy)methyl)-4-(2-methoxy-2-oxoethyl)-2-oxopyrrolidine-1-carboxylate

tert-butyl (3S,4S,5S)-3-((S)-1-(1,3-dioxolan-2-yl)ethyl)-5-(((tert-butyldimethylsilyl)oxy)methyl)-4-(2-methoxy-2-oxoethyl)-2-oxopyrrolidine-1-carboxylate

1-(tert-butyl) 2-methyl (2S,3S,4S)-4-((S)-1-(1,3-dioxolan-2-yl)ethyl)-3-(2-methoxy-2-oxoethyl)pyrrolidine-1,2-dicarboxylate

1-(tert-butyl) 2-methyl (2S,3S,4S)-4-((S)-1-(1,3-dioxolan-2-yl)ethyl)-3-(2-methoxy-2-oxoethyl)pyrrolidine-1,2-dicarboxylate

(R,3E,5Z)-6-((3S,4S,5S)-1-(tert-butoxycarbonyl)-4-(2-methoxy-2-oxoethyl)-5-(methoxycarbonyl)pyrrolidin-3-yl)-2-methylhepta-3,5-dienoic acid

(R,3E,5Z)-6-((3S,4S,5S)-1-(tert-butoxycarbonyl)-4-(2-methoxy-2-oxoethyl)-5-(methoxycarbonyl)pyrrolidin-3-yl)-2-methylhepta-3,5-dienoic acid

上游原料

(2S,3S,4S)-1-tert-butyl 2-methyl 3-(2-methoxy-2-oxoethyl)-4-((R)-1-oxopropan-2-yl)pyrrolidine-1,2-dicarboxylate 1-(tert-butyl) 2-methyl (2S,3S,4R)-3-(2-methoxy-2-oxoethyl)-4-(4-methoxybut-3-en-2-yl)pyrrolidine-1,2-dicarboxylate tert-butyl (2S,3S,4S)-4-((S)-1-(1,3-dioxolan-2-yl)ethyl)-3-(2-hydroxyethyl)-2-(hydroxymethyl)pyrrolidine-1-carboxylate tert-butyl (3S,4S,5S)-3-((S)-1-(1,3-dioxolan-2-yl)ethyl)-5-(((tert-butyldimethylsilyl)oxy)methyl)-4-(2-methoxy-2-oxoethyl)-2-oxopyrrolidine-1-carboxylate 1-(tert-butyl) 2-methyl (2S,3S,4S)-4-((S)-1-(1,3-dioxolan-2-yl)ethyl)-3-(2-methoxy-2-oxoethyl)pyrrolidine-1,2-dicarboxylate (R,3E,5Z)-6-((3S,4S,5S)-1-(tert-butoxycarbonyl)-4-(2-methoxy-2-oxoethyl)-5-(methoxycarbonyl)pyrrolidin-3-yl)-2-methylhepta-3,5-dienoic acid (2S,3S,4S)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(1-[1,3]dioxolan-2-yl-ethyl)-3-(2-hydroxy-ethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 1-(tert-butyl) 2-methyl (2S,3S,4S)-3-(2-methoxy-2-oxoethyl)-4-(4-oxo-3-(phenylselanyl)butan-2-yl)pyrrolidine-1,2-dicarboxylate 1-(tert-butyl) 2-methyl (2S,3S,4S)-4-((R,2Z,4E)-7-hydroxy-6-methylhepta-2,4-dien-2-yl)-3-(2-methoxy-2-oxoethyl)pyrrolidine-1,2-dicarboxylate 1-(tert-butyl) 2-methyl (2S,3S,4S)-3-(2-methoxy-2-oxoethyl)-4-((Z)-4-oxobut-2-en-2-yl)pyrrolidine-1,2-dicarboxylate