沛马沙星_CAS号:143383-65-7_分子式、生产方法、用途、产品-灵元素

基本信息

中文名称

沛马沙星

英文名称

1-cyclopropyl-6-fluoro-8-methoxy-7-[(3R)-3-[(1S)-1-(methylamino)ethyl]pyrrolidin-1-yl]-4-oxoquinoline-3-carboxylic acid

中文别名

英文别名

1-cyclopropyl-6-fluoro-8-methoxy-7-[3-(1-methylamino-ethyl)-pyrrolidin-1-yl]-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid、Premafloxacin (USAN/INN)、Premafloxacin、JB-1、UNII-UOM2HMO524

CAS号

143383-65-7

分子式

C21H26FN3O4

分子量

403.447

精确质量

403.191

PSA

83.8

LOGP

3.0724

编号系统

UNII

UOM2HMO524

物化性质

密度

1.354g/cm3

沸点

601.3ºC at 760mmHg

闪点

317.4ºC

折射率

1.615

蒸汽压

2.63E-15mmHg at 25°C

合成路线

143409-01-2

3R,1S-1-cyclopropyl-6-fluoro-7-[3-(1-N-tertbutoxycarbonyl-N-methylaminoethyl)-1-pyrrolidinyl]-8-methoxy-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

上游原料

tert-butyl ((S)-1-((R)-1-(1-cyclopropyl-3-(((difluoroboranyl)oxy)carbonyl)-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinolin-7-yl)pyrrolidin-3-yl)ethyl)(methyl)carbamate

847233-56-1

[1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-(oxo-κO)-3-quinoline-carboxylato-κO3]difluoroboron

143409-01-2

3R,1S-1-cyclopropyl-6-fluoro-7-[3-(1-N-tertbutoxycarbonyl-N-methylaminoethyl)-1-pyrrolidinyl]-8-methoxy-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

143408-75-7

1,1-dimethylethyl [S-(R*,S*)]-methyl[1-(3-pyrrolidinyl)ethyl]carbamate