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地利洛非

地利洛非

CAS号：14357-78-9

英文名：Diprenorphine,17-(Cyclopropylmethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-α,α-dimethyl-6,14-ethenomorphinan-7-methanol

分子式

C26H35NO4

熔点

密度

1.33 g/cm3

分子量

425.56

沸点

溶解度

信号词

危险品标志

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化合物简介

Diprenorphine (brand name Revivon; former developmental code name M5050), also known as diprenorfin, is a non-selective, high-affinity, weak partial agonist of the μ- (MOR), κ- (KOR), and δ-opioid receptor (DOR) (with equal affinity) that is employed in veterinary medicine as an opioid antagonist. It is used to reverse the effects of super-potent opioid analgesics such as etorphine and carfentanil that are used for tranquilizing large animals. The drug is not approved for use in humans.

基本信息

中文名称

地利洛非

英文名称

Diprenorphine,17-(Cyclopropylmethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-α,α-dimethyl-6,14-ethenomorphinan-7-methanol

中文别名

利巴韦林杂质

英文别名

DIPRENORPHINE、RX-5050M、Diprenorphin、DIPRENORPHINE POTENT OPIOID ANTAGON、diprenorpine、M-5050

CAS号

14357-78-9

分子式

C26H35NO4

分子量

425.56

精确质量

425.257

PSA

62.16

LOGP

3.3255

编号系统

UNII

1F0L5N25ZZ

物化性质

密度

1.33 g/cm3

折射率

1.656

安全信息

危险类别码

R20/21/22

危险品标志

Xn

合成路线

N-nordiprenorphine

N-nordiprenorphine

环丙甲醛

地利洛非

上游原料

共找到23个上游原料 >

1-[(5alpha,7alpha)-4,5-环氧-3,6-二甲氧基-17-甲基-6,14-乙烯桥吗喃-7-基]乙酮

1-[(5alpha,7alpha)-4,5-环氧-3,6-二甲氧基-17-甲基-6,14-乙烯桥吗喃-7-基]乙酮

N-Benzyl-northebain

N-Benzyl-northebain

(4R,4aS,6R,7R,7aR,12bS)-3-(cyclopropylmethyl)-6-(2-hydroxypropan-2-yl)-9-methoxy-1,2,3,4,5,6-hexahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinolin-7(7aH)-ol

(4R,4aS,6R,7R,7aR,12bS)-3-(cyclopropylmethyl)-6-(2-hydroxypropan-2-yl)-9-methoxy-1,2,3,4,5,6-hexahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinolin-7(7aH)-ol

N-nordiprenorphine

N-nordiprenorphine

2-(4,5α-epoxy-3,6-dimethoxy-6α,14α-ethano-morphinan-7α-yl)-propan-2-ol

2-(4,5α-epoxy-3,6-dimethoxy-6α,14α-ethano-morphinan-7α-yl)-propan-2-ol

(4R,7aR,12bS)-7,9-dimethoxy-1,2,3,4,7a,13-hexahydro-4,12-methanobenzofuro[3,2-e]isoquinoline

(4R,7aR,12bS)-7,9-dimethoxy-1,2,3,4,7a,13-hexahydro-4,12-methanobenzofuro[3,2-e]isoquinoline

上游原料

1-[(5alpha,7alpha)-4,5-环氧-3,6-二甲氧基-17-甲基-6,14-乙烯桥吗喃-7-基]乙酮 N-Benzyl-northebain (4R,4aS,6R,7R,7aR,12bS)-3-(cyclopropylmethyl)-6-(2-hydroxypropan-2-yl)-9-methoxy-1,2,3,4,5,6-hexahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinolin-7(7aH)-ol N-nordiprenorphine 2-(4,5α-epoxy-3,6-dimethoxy-6α,14α-ethano-morphinan-7α-yl)-propan-2-ol (4R,7aR,12bS)-7,9-dimethoxy-1,2,3,4,7a,13-hexahydro-4,12-methanobenzofuro[3,2-e]isoquinoline 溴甲基环丙烷 cyclopropyl((4R,4aS,6R,7R,7aR,12bS)-6-(2-hydroxypropan-2-yl)-7,9-dimethoxy-1,2,5,6,7,7a-hexahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinolin-3(4H)-yl)methanone (5R,6R,7S,9R,13S,14S)-17-Cyclopropylmethyl-4,5-epoxy-18,19-dihydro-3,6-dimethoxy-α,α-dimethyl-6,14-ethanomorphinan-7-methanol 蒂巴因 3-(O-t-butyldimethylsilyl)-6-(O-desmethyl)-diprenorphine (5R,6R,7S,9R,13S,14S)-7-Acetyl-4,5-epoxy-17-formyl-18,19-dihydro-3,6-dimethoxy-6,14-ethanomorphinan (5R,6R,7S,9R,13S,14S)-7-Acetyl-4,5-epoxy-18,19-dihydro-3,6-dimethoxy-6,14-ethanomorphinan 甲基碘 (5R,6R,7S,9R,13S,14S)-7-Acetyl-17-cyclopropylmethyl-4,5-epoxy-18,19-dihydro-3,6-dimethoxy-6,14-ethanomorphinan 1-[(5alpha,7alpha)-4,5-环氧-18,19-二氢-3,6-二甲氧基-17-甲基-6,14-乙烯桥吗喃-7-基]乙酮 4,5α-epoxy-7α-(1-hydroxy-1-methyl-ethyl)-3,6-dimethoxy-6α,14α-ethano-morphinane-17-carbonitrile N-demethyl-N-formylthebaibe (5R,6R,7S,9R,13S,14R)-7-Acetyl-4,5-epoxy-17-formyl-3,6-dimethoxy-6,14-ethenomorphinan (5R,6R,7S,9R,13S,14R)-7-Acetyl-17-benzyl-4,5-epoxy-3,6-dimethoxy-6,14-ethenomorphinan dihydromethylthevinol 6-O-desmethyl-diprenorphine 环丙甲醛