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(3E,5E,7R,8R,9S,10S,11R,13E,15E,17S,18R)-18-[(2S,3R,4S)-4-[(2R,4R,5S,6R)-2,4-二羟基-5-甲基-6-[(E)-丙-1-烯基]四氢吡喃-2-基]-3-羟基戊烷-2-基]-9-乙基-8,10-二羟基-3,17-二甲氧基-5,7,11,13-四甲基-1-氧杂环十八碳-3,5,13,15-四烯-2-酮

(3E,5E,7R,8R,9S,10S,11R,13E,15E,17S,18R)-18-[(2S,3R,4S)-4-[(2R,4R,5S,6R)-2,4-二羟基-5-甲基-6-[(E)-丙-1-烯基]四氢吡喃-2-基]-3-羟基戊烷-2-基]-9-乙基-8,10-二羟基-3,17-二甲氧基-5,7,11,13-四甲基-1-氧杂环十八碳-3,5,13,15-四烯-2-酮

CAS号：144539-92-4

英文名：(3E,5E,7R,8R,9S,10S,11R,13E,15E,17S,18R)-18-[(2S,3R,4S)-4-[(2R,4R,5S,6R)-2,4-dihydroxy-5-methyl-6-[(E)-prop-1-enyl]oxan-2-yl]-3-hydroxypentan-2-yl]-9-ethyl-8,10-dihydroxy-3,17-dimethoxy-5,7,11,13-tetramethyl-1-oxacyclooctadeca-3,5,13,15-tetraen-2-one

分子式

C39H64O10

熔点

密度

1.14g/cm3

分子量

692.919

沸点

828.2ºC at 760mmHg

溶解度

信号词

危险品标志

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基本信息

中文名称

(3E,5E,7R,8R,9S,10S,11R,13E,15E,17S,18R)-18-[(2S,3R,4S)-4-[(2R,4R,5S,6R)-2,4-二羟基-5-甲基-6-[(E)-丙-1-烯基]四氢吡喃-2-基]-3-羟基戊烷-2-基]-9-乙基-8,10-二羟基-3,17-二甲氧基-5,7,11,13-四甲基-1-氧杂环十八碳-3,5,13,15-四烯-2-酮

英文名称

(3E,5E,7R,8R,9S,10S,11R,13E,15E,17S,18R)-18-[(2S,3R,4S)-4-[(2R,4R,5S,6R)-2,4-dihydroxy-5-methyl-6-[(E)-prop-1-enyl]oxan-2-yl]-3-hydroxypentan-2-yl]-9-ethyl-8,10-dihydroxy-3,17-dimethoxy-5,7,11,13-tetramethyl-1-oxacyclooctadeca-3,5,13,15-tetraen-2-one

中文别名

英文别名

Concanamycin F、concanolide A

CAS号

144539-92-4

分子式

C39H64O10

分子量

692.919

精确质量

692.45

PSA

155.14

LOGP

4.9999

物化性质

密度

1.14g/cm3

沸点

828.2ºC at 760mmHg

闪点

243.7ºC

折射率

1.544

蒸汽压

8.12E-32mmHg at 25°C

合成路线

(2R,3R,4S,5S,6R)-4-ethyl-3,5-dihydroxy-2,6-dimethylnon-8-yn-1-yl pivalate

(2R,3R,4S,5S,6R)-4-ethyl-3,5-dihydroxy-2,6-dimethylnon-8-yn-1-yl pivalate

(3E,5E,7R,8R,9S,10S,11R,13E,15E,17S,18R)-18-[(2S,3R,4S)-4-[(2R,4R,5S,6R)-2,4-二羟基-5-甲基-6-[(E)-丙-1-烯基]四氢吡喃-2-基]-3-羟基戊烷-2-基]-9-乙基-8,10-二羟基-3,17-二甲氧基-5,7,11,13-四甲基-1-氧杂环十八碳-3,5,13,15-四烯-2-酮

(3E,5E,7R,8R,9S,10S,11R,13E,15E,17S,18R)-18-[(2S,3R,4S)-4-[(2R,4R,5S,6R)-2,4-二羟基-5-甲基-6-[(E)-丙-1-烯基]四氢吡喃-2-基]-3-羟基戊烷-2-基]-9-乙基-8,10-二羟基-3,17-二甲氧基-5,7,11,13-四甲基-1-氧杂环十八碳-3,5,13,15-四烯-2-酮

上游原料

共找到52个上游原料 >

methyl (2Z,4E,6R,7R,8S,9S,10R,12E,14E,16S,17R,18S)-7,9-bis((diethyl(isopropyl)silyl)oxy)-8-ethyl-17,19-dihydroxy-2,16-dimethoxy-4,6,10,12,18-pentamethylnonadeca-2,4,12,14-tetraenoate

methyl (2Z,4E,6R,7R,8S,9S,10R,12E,14E,16S,17R,18S)-7,9-bis((diethyl(isopropyl)silyl)oxy)-8-ethyl-17,19-dihydroxy-2,16-dimethoxy-4,6,10,12,18-pentamethylnonadeca-2,4,12,14-tetraenoate

(2R,3R,4S,5R)-5-benzoyloxy-1-benzyloxy-2,4-dimethylhexan-3-ol

(2R,3R,4S,5R)-5-benzoyloxy-1-benzyloxy-2,4-dimethylhexan-3-ol

21,23-Di-O-methylconcanolide A

21,23-Di-O-methylconcanolide A

(E)-(2R,3R)-3-(4-Methoxy-benzyloxy)-2-methyl-hex-4-enal

(E)-(2R,3R)-3-(4-Methoxy-benzyloxy)-2-methyl-hex-4-enal

(2E,10E,12E)-(4R,5R,6S,7S,8R,14S)-5,7-Bis-(diethyl-isopropyl-silanyloxy)-6-ethyl-14-methoxy-2,4,8,10-tetramethyl-14-((4R,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-tetradeca-2,10,12-trienal

(2E,10E,12E)-(4R,5R,6S,7S,8R,14S)-5,7-Bis-(diethyl-isopropyl-silanyloxy)-6-ethyl-14-methoxy-2,4,8,10-tetramethyl-14-((4R,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-tetradeca-2,10,12-trienal

(2R,3R,4S,5S,6R)-4-ethyl-3,5-dihydroxy-2,6-dimethylnon-8-yn-1-yl pivalate

(2R,3R,4S,5S,6R)-4-ethyl-3,5-dihydroxy-2,6-dimethylnon-8-yn-1-yl pivalate

上游原料

methyl (2Z,4E,6R,7R,8S,9S,10R,12E,14E,16S,17R,18S)-7,9-bis((diethyl(isopropyl)silyl)oxy)-8-ethyl-17,19-dihydroxy-2,16-dimethoxy-4,6,10,12,18-pentamethylnonadeca-2,4,12,14-tetraenoate (2R,3R,4S,5R)-5-benzoyloxy-1-benzyloxy-2,4-dimethylhexan-3-ol 21,23-Di-O-methylconcanolide A (E)-(2R,3R)-3-(4-Methoxy-benzyloxy)-2-methyl-hex-4-enal (2E,10E,12E)-(4R,5R,6S,7S,8R,14S)-5,7-Bis-(diethyl-isopropyl-silanyloxy)-6-ethyl-14-methoxy-2,4,8,10-tetramethyl-14-((4R,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-tetradeca-2,10,12-trienal (2R,3R,4S,5S,6R)-4-ethyl-3,5-dihydroxy-2,6-dimethylnon-8-yn-1-yl pivalate (3Z,5E,7R,8R,9S,10S,11R,13E,15E,17S,18R)-18-((2R,3R,4S)-3-((diethyl(isopropyl)silyl)oxy)-4-methyl-5-oxohexan-2-yl)-9-ethyl-3,17-dimethoxy-5,7,11,13-tetramethyl-8,10-bis((triethylsilyl)oxy)oxacyclooctadeca-3,5,13,15-tetraen-2-one (2S,4R,5R,6E)-2-benzoyloxy-5-diethylisopropylsilyloxy-4-methyloct-6-en-3-one (3S,4R,E)-4-((4-methoxybenzyl)oxy)-3-methylhept-5-ene-1,2-diol 1-((4R,5S,6R)-2,2-di-tert-butyl-5-methyl-6-((E)-prop-1-en-1-yl)-1,3,2-dioxasilinan-4-yl)butan-2-ol (2S)-2-((4R,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)butan-1-ol 1-methoxy-4-((((3S,4R,E)-3-methylhepta-1,5-dien-4-yl)oxy)methyl)benzene (2R,3R,4S,5R)-4-((diethyl(isopropyl)silyl)oxy)-5-((2R,3S,4E,6E,9R,10S,11S,12R,13R,14E,16Z)-11-ethyl-3,17-dimethoxy-7,9,13,15-tetramethyl-18-oxo-10,12-bis((triethylsilyl)oxy)oxacyclooctadeca-4,6,14,16-tetraen-2-yl)-3-methylhexan-2-yl benzoate (2S,3S,4S,5S,6R,8E,10E,12S)-3,5-bis((diethyl(isopropyl)silyl)oxy)-4-ethyl-12-methoxy-2,6,8-trimethyl-12-((4R,5S)-2,2,5-trimethyl-1,3-dioxan-4-yl)dodeca-8,10-dienal (3S,4R,5R,6R,7R,8R)-8-benzoyloxy-6-diethylisopropylsilyloxy-4-hydroxy-3-methoxy-5,7-dimethylnon-1-yne (2R,3R,4S,5S,6R,8E,10E,12S)-3,5-bis((diethyl(isopropyl)silyl)oxy)-4-ethyl-12-methoxy-2,6,8-trimethyl-12-((4R,5S)-2,2,5-trimethyl-1,3-dioxan-4-yl)dodeca-8,10-dien-1-yl pivalate Benzoic acid (7E,9E,17E,19Z)-(1R,2R,3R,4R,5R,6S,12R,13S,14S,15R,16R)-3-(diethyl-isopropyl-silanyloxy)-14-ethyl-5-hydroxy-6,20-dimethoxy-20-methoxycarbonyl-1,2,4,10,12,16,18-heptamethyl-13,15-bis-triethylsilanyloxy-icosa-7,9,17,19-tetraenyl ester 1-((4R,5S,6R)-2,2-di-tert-butyl-5-methyl-6-((E)-prop-1-en-1-yl)-1,3,2-dioxasilinan-4-yl)butan-2-one (5R,6S,7R,E)-5-hydroxy-7-((4-methoxybenzyl)oxy)-6-methyldec-8-en-3-one (2E,4R,5R,6S,7S,8R,10E,12E,14S)-5,7-bis((diethyl(isopropyl)silyl)oxy)-6-ethyl-14-methoxy-2,4,8,10-tetramethyl-14-((4R,5S)-2,2,5-trimethyl-1,3-dioxan-4-yl)tetradeca-2,10,12-trien-1-ol methyl (2Z,4E,6R,7R,8S,9S,10R,12E,14E,16S,17R,18S)-7,9-bis((diethyl(isopropyl)silyl)oxy)-8-ethyl-17-hydroxy-2,16-dimethoxy-19-((4-methoxyphenyl)diphenylmethoxy)-4,6,10,12,18-pentamethylnonadeca-2,4,12,14-tetraenoate (2S,3S,4R,5R)-5-benzoyloxy-3-diethylisopropylsilyloxy-2,4-dimethylhexanal methyl (2Z,4E,6R,7R,8S,9S,10R,12E,14E,16S)-7,9-bis((diethyl(isopropyl)silyl)oxy)-8-ethyl-2,16-dimethoxy-4,6,10,12-tetramethyl-16-((4R,5S)-2,2,5-trimethyl-1,3-dioxan-4-yl)hexadeca-2,4,12,14-tetraenoate (2S,4R,5R,6R,7R,8R,9R)-2,9-dibenzoyloxy-7-diethylisopropylsilyloxy-5-hydroxy-4-methoxy-6,8-dimethyldecan-3-one (2Z,4E,6R,7R,8S,9S,10R,12E)-7,9-bis((diethyl(isopropyl)silyl)oxy)-8-ethyl-13-iodo-2-methoxy-4,6,10,12-tetramethyltrideca-2,4,12-trienoic acid (2S,3RS,4S,5R,6E)-5-diethylisopropylsilyloxy-4-methyloct-6-ene-2,3-diol (3Z,5E,7R,8R,9S,10S,11R,13E,15E,17S,18R)-8,10-bis((diethyl(isopropyl)silyl)oxy)-9-ethyl-3,17-dimethoxy-18-((S)-1-((4-methoxyphenyl)diphenylmethoxy)propan-2-yl)-5,7,11,13-tetramethyloxacyclooctadeca-3,5,13,15-tetraen-2-one 1-((4R,5S,6R)-2-(4-methoxyphenyl)-5-methyl-6-((E)-prop-1-en-1-yl)-1,3-dioxan-4-yl)butan-2-ol (2R,4R,5R)-1-benzyloxy-5-hydroxy-2,4-dimethylhexan-3-one (2R,3R,4R,5R,6R,7R)-7-benzoyloxy-5-diethylisopropylsilyloxy-3-hydroxy-2-methoxy-4,6-dimethyloctanal (3Z,5E,7R,8R,9S,10S,11R,13E,15E,17S,18R)-8,10-bis((diethyl(isopropyl)silyl)oxy)-9-ethyl-18-((S)-1-hydroxypropan-2-yl)-3,17-dimethoxy-5,7,11,13-tetramethyloxacyclooctadeca-3,5,13,15-tetraen-2-one 1-((4R,5S,6R)-2,2-di-tert-butyl-5-methyl-6-((E)-prop-1-en-1-yl)-1,3,2-dioxasilinan-4-yl)butan-2-yl acetate 23-O-Methylconcanolide A (4R,5R,6S,7S,8R,E)-5,7-bis((diethyl(isopropyl)silyl)oxy)-6-ethyl-2,4,8-trimethylundec-2-en-10-yn-1-ol methyl (2Z,4E,6R,7R,8S,9S,10R,12E)-7,9-bis((diethyl(isopropyl)silyl)oxy)-8-ethyl-13-iodo-2-methoxy-4,6,10,12-tetramethyltrideca-2,4,12-trienoate (2E,4R,5R,6S,7S,8R,10E)-5,7-bis((diethyl(isopropyl)silyl)oxy)-6-ethyl-11-iodo-2,4,8,10-tetramethylundeca-2,10-dien-1-ol (3S,4R,E)-3-methylhepta-1,5-dien-4-ol (8E,10E)-(2R,3R,4S,5S,6R,12S)-3,5-Bis-(diethyl-isopropyl-silanyloxy)-4-ethyl-12-methoxy-2,6,8-trimethyl-12-((4R,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-dodeca-8,10-dien-1-ol (E)-(4R,5R,6S,7S,8R)-5,7-Bis-(diethyl-isopropyl-silanyloxy)-6-ethyl-2,4,8-trimethyl-undec-2-en-10-ynoic acid ethyl ester (2Z,4E,6R,7R,8S,9S,10R,12E,14E,16S,17R,18R,19R,20R,21R)-21-(benzoyloxy)-19-((diethyl(isopropyl)silyl)oxy)-8-ethyl-17-hydroxy-2,16-dimethoxy-4,6,10,12,18,20-hexamethyl-7,9-bis((triethylsilyl)oxy)docosa-2,4,12,14-tetraenoic acid (2E,4R,5R,6S,7S,8R,10E)-5,7-bis((diethyl(isopropyl)silyl)oxy)-6-ethyl-11-iodo-2,4,8,10-tetramethylundeca-2,10-dienal (5R,6S,7R,E)-5,7-dihydroxy-6-methyldec-8-en-3-yl acetate (R)-2-((2R,3S,4E,6E,9R,10S,11S,12R,13R,14E,16Z)-10,12-bis((diethyl(isopropyl)silyl)oxy)-11-ethyl-3,17-dimethoxy-7,9,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6,14,16-tetraen-2-yl)propanal (2R,3R,4E)-3-diethylisopropylsilyloxy-2-methylhex-4-enal (2S,4R,5R,6E)-2-benzoyloxy-5-hydroxy-4-methyloct-6-en-3-one