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米格列奈

米格列奈

CAS号：145375-43-5

英文名：[2(S)-cis]-Octahydro-γ-oxo-α-(phenylmethyl)-2H-isoindole-2-butanoic acid

分子式

C19H25NO3

熔点

密度

1.175

分子量

315.407

沸点

519.6ºC at 760 mmHg

溶解度

信号词

危险品标志

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基本信息

中文名称

米格列奈

英文名称

[2(S)-cis]-Octahydro-γ-oxo-α-(phenylmethyl)-2H-isoindole-2-butanoic acid

中文别名

(2S)-2-苄基-3-(顺式全氢异吲哚-2-羰基)丙酸

英文别名

Unii-D86I0xlb13、Mitiglinide

CAS号

145375-43-5

分子式

C19H25NO3

分子量

315.407

精确质量

315.183

PSA

57.61

LOGP

2.9065

编号系统

UNII

D86I0XLB13

物化性质

密度

1.175

沸点

519.6ºC at 760 mmHg

闪点

268ºC

折射率

1.567

蒸汽压

1.27E-11mmHg at 25°C

安全信息

海关编码

2942000000

合成路线

(3aS,6R,7aS)-8,8-dimethyl-1-{(2S)-4-[(3aR,7aS)-octahydro-2H-isoindol-2-yl]-4-oxo-2-(phenylmethyl)butanoyl}hexahydro-3a,6-methano-2,1-benzisothiazole 2,2-dioxide

(3aS,6R,7aS)-8,8-dimethyl-1-{(2S)-4-[(3aR,7aS)-octahydro-2H-isoindol-2-yl]-4-oxo-2-(phenylmethyl)butanoyl}hexahydro-3a,6-methano-2,1-benzisothiazole 2,2-dioxide

米格列奈

上游原料

共找到23个上游原料 >

(S)-2-Benzyl-4-(3aR,7aS)-octahydro-isoindol-2-yl-4-oxo-butyric acid (1R,2S,6R,7S)-3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl ester

(S)-2-Benzyl-4-(3aR,7aS)-octahydro-isoindol-2-yl-4-oxo-butyric acid (1R,2S,6R,7S)-3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl ester

DL-苄基琥珀酸

DL-苄基琥珀酸

ethyl 4-[(3aR,7aS)-octahydro-2H-isoindol-2-yl]-4-oxo-2-benzyl-butanoate

ethyl 4-[(3aR,7aS)-octahydro-2H-isoindol-2-yl]-4-oxo-2-benzyl-butanoate

(S)-2-Benzyl-succinic acid 4-((1S,2R,6S,7R)-3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl) ester 1-((1R,2S,6R,7S)-3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl) ester

(S)-2-Benzyl-succinic acid 4-((1S,2R,6S,7R)-3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl) ester 1-((1R,2S,6R,7S)-3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl) ester

(3aR,7aS)-2-chloroacetyl-octahydro-2H-isoindole

(3aR,7aS)-2-chloroacetyl-octahydro-2H-isoindole

(S)-2-Benzyl-4-(3aR,7aS)-octahydro-isoindol-2-yl-4-oxo-butyric acid methyl ester

(S)-2-Benzyl-4-(3aR,7aS)-octahydro-isoindol-2-yl-4-oxo-butyric acid methyl ester

上游原料

(S)-2-Benzyl-4-(3aR,7aS)-octahydro-isoindol-2-yl-4-oxo-butyric acid (1R,2S,6R,7S)-3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl ester DL-苄基琥珀酸 ethyl 4-[(3aR,7aS)-octahydro-2H-isoindol-2-yl]-4-oxo-2-benzyl-butanoate (S)-2-Benzyl-succinic acid 4-((1S,2R,6S,7R)-3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl) ester 1-((1R,2S,6R,7S)-3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl) ester (3aR,7aS)-2-chloroacetyl-octahydro-2H-isoindole (S)-2-Benzyl-4-(3aR,7aS)-octahydro-isoindol-2-yl-4-oxo-butyric acid methyl ester (3S)-3-benzyl-4-oxo-4-phenylmethoxybutanoate 4-nitrophenyl (S)-2-benzyl-4-((3aR,7aS)-octahydro-2H-isoindol-2-yl)-4-oxobutanoate ethyl 4-[(3aR,7aS)-octahydro-2H-isoindol-2-yl]-4-oxo-2-benzyl-2-carbethoxy-butanoate (S)-2-Benzyl-4-(3aR,7aS)-octahydro-isoindol-2-yl-4-oxo-butyric acid (S)-benzylcarbamoyl-phenyl-methyl ester (E)-benzylidenesuccinic anhydride 4-[(3aR,7aS)-octahydro-2H-isoindol-2-yl]-4-oxo-2-benzyl-butanoic acid (3aS,6R,7aS)-hexahydro-8,8-dimethyl-1-(3-phenylpropanoyl)-3H-3a,6-methano-2,1-benzisothiazole 2,2-dioxide (3S)-4-[(3aS,6R,7aS)-tetrahydro-8,8-dimethyl-2,2-dioxido-3a,6-methano-2,1-benzisothiazol-1(4H)-yl]-4-oxo-3-(phenylmethyl)butanoic acid 1,1-dimethylethyl (3S)-4-[(3aS,6R,7aS)-8,8-dimethyl-2,2-dioxidotetrahydro-3a,6-methano-2,1-benzisothiazol-1(4H)-yl]-4-oxo-3-(phenylmethyl)butanoate (S)-2-Benzyl-succinic acid bis-(4-nitro-phenyl) ester (3aR,7aS)-2-(bromoacetyl)octahydro-1H-isoindole 3-苯基丙酰氯 (2S)-2-benzyl-1-((4R)-4-benzyl-2-oxo-oxazolidin-3-yl)-4-(cis-hexahydro-isoindolin-2-yl)-butane-1,4-dione (S)-2-苄基琥珀酸 (3aS,6R,7aS)-8,8-dimethyl-1-{(2S)-4-[(3aR,7aS)-octahydro-2H-isoindol-2-yl]-4-oxo-2-(phenylmethyl)butanoyl}hexahydro-3a,6-methano-2,1-benzisothiazole 2,2-dioxide 顺式全氢异吲哚