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多尼培南

多尼培南

CAS号:148016-81-3
英文名:Doripenem
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化合物简介
Doripenem is an ultra-broad-spectrum injectable antibiotic. It is a beta-lactam and belongs to the subgroup of carbapenems. It was launched by Shionogi Co. of Japan under the brand name Finibax in 2005 and is being marketed outside Japan by Johnson & Johnson. It is particularly active against Pseudomonas aeruginosa. The usual form is doripenem monohydrate.
基本信息
编号系统
物化性质
上游原料
(2S,4S)-1-p-methoxybenzyloxycarbonyl-4tritylthio-2-(p-methoxybenzyloxycarbonylaminosulfonylaminomethyl)pyrrolidine (2S,4R)-N-tetr-butoxycarbonyl-4-methanesulfonyloxy-2-hydroxymethylpyrrolidine (2S,4S)-2-aminomethyl-1-p-methoxybenzyloxycarbonyl-4-tritylthiopyrrolidine L-羟基脯氨酸 Boc-L-羟脯氨酸 反式-4-羟基-L-脯氨酸甲酯 多尼培南缩合物 (1R,5S,6S)-2-[(3S,5S)-1-allyloxycarbonyl-5-(N-sulfamoylamino) methylpyrrolidin-3-yl]thio-6-[(1R)-1-hydroxyethyl]-1-methyl-1-carba-2-penem-3-carboxylic acid allyl ester 2-Methyl-2-propanyl (2S,4S)-4-(acetylsulfanyl)-2-{[{[(2-methyl-2- propanyl)oxy]carbonyl}(sulfamoyl)amino]methyl}-1-pyrrolidinecarbo xylate (2S,4S)-2-[[(氨基磺酰基)(叔丁氧羰基)氨基]甲基]-4-巯基-1-吡咯烷羧酸叔丁酯 4-methoxybenzyl (4R,5S,6S)-6-((R)-1-hydroxyethyl)-3-(((3S,5S)-1-(((4-methoxybenzyl)oxy)carbonyl)-5-(((N-(((4-methoxybenzyl)oxy)carbonyl)sulfamoyl)amino)methyl)pyrrolidin-3-yl)thio)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate (2S,4R)-1-p-methoxybenzyloxycarbonyl-4-methanesulfonyloxypyrrolidine-2-carboxylic acid methyl ester (2S,4S)-4-(乙酰基硫代)-2-(羟基甲基)-1-吡咯烷羧酸-1,1-二甲基乙酯 diphenylmethyl (4R,5S,6S)-6-[(1R)-1-hydroxyethyl]-4-methyl-3-[[(3S,5S)-1-(tert-butoxycarbonyl)-5-[N-sulfamoyl-N-(tert-butoxycarbonyl)aminomethyl]pyrrolidin-3-yl]thio]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate 4-nitrobenzyl (4R,5R,6S)-6-[(1R)-1-hydroxyethyl]-4-methyl-3,7-dioxo-1-azabicyclo[3.2.0]-heptane-2-carboxylate (R)-4-硝基苄基-2-重氮-4-((2R,3S)-3-((R)-1-羟乙基)-氮杂环丁-4-酮-2-基]-3-氧代戊酸酯 (2S,4R)-1-p-methoxybenzyloxycarbonyl-4-hydroxypyrrolidine-2-carboxylic acid methyl ester (2S,4S)-1-p-methoxybenzyloxycarbonyl-2-phthalimidomethyl-4-tritylthiopyrrolidine (2S,4S)-1-p-methoxybenzyloxycarbonyl-4-tritylthiopyrrolidine-2-carboxylic acid methyl ester (2S,4S)-1-p-methoxybenzyloxycarbonyl-4-tritylthiopyrrolidine-2-methanol