7-O-(三乙基硅烷基)紫杉醇

7-O-(三乙基硅烷基)紫杉醇

CAS号：148930-55-6

英文名：7-O-(Triethylsilyl) Paclitaxel

分子式

C53H65NO14Si

熔点

密度

分子量

968.167

沸点

溶解度

信号词

危险品标志

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化合物简介

Protected Paclitaxel.

基本信息

中文名称

7-O-(三乙基硅烷基)紫杉醇

英文名称

7-O-(Triethylsilyl) Paclitaxel

中文别名

英文别名

7-O-(Triethylsilyl)taxol

CAS号

148930-55-6

分子式

C53H65NO14Si

分子量

968.167

精确质量

967.417

PSA

213.78

LOGP

7.34

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194420-28-5

7-O-(三乙基硅烷基)紫杉醇

7-O-(三乙基硅烷基)紫杉醇

上游原料

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(1R,2S,3S,5R,6S,7S,8S,9S)-2,6-Dibenzyloxy-3-(3-butenyl)-5-(tert-butyldimethylsiloxy)-7,9-(isopropylidenedioxy)-4,4,8-trimethyl-12-methylenebicyclo[6.4.0]dodecan-3-ol

(1R,2S,3S,5R,6S,7S,8S,9S)-2,6-Dibenzyloxy-3-(3-butenyl)-5-(tert-butyldimethylsiloxy)-7,9-(isopropylidenedioxy)-4,4,8-trimethyl-12-methylenebicyclo[6.4.0]dodecan-3-ol

(4S,4aS,6R,11S,12S,12aR)-11,12-(Carbonyldioxy)-4a,8,13,13-tetramethyl-1-methylene-5-oxo-4-triethylsiloxy-1,2,3,4,4a,5,6,9,10,11,12,12a-dodecahydro-7,11-methanobenzocyclodecen-6-yl acetate

(4S,4aS,6R,11S,12S,12aR)-11,12-(Carbonyldioxy)-4a,8,13,13-tetramethyl-1-methylene-5-oxo-4-triethylsiloxy-1,2,3,4,4a,5,6,9,10,11,12,12a-dodecahydro-7,11-methanobenzocyclodecen-6-yl acetate

2-bromo-5-(triethylsilyloxy)pentene

2-bromo-5-(triethylsilyloxy)pentene

1,2-O,O-Carbonyl-7,13-O,O-bis(triethylsilyl)-4-deacetyl-2-debenzoylbaccatin III

1,2-O,O-Carbonyl-7,13-O,O-bis(triethylsilyl)-4-deacetyl-2-debenzoylbaccatin III

(1S,2S,3S,6S,7S,8R,12S)-3,7-Dibenzyloxy-6-(cyclohexyldimethylsiloxy)-2,12-(isopropylidenedioxy)-1,5,5-trimethyl-9-methylene-6-(3-oxobutyl)bicyclo[6.4.0]dodecan-4-one

(1S,2S,3S,6S,7S,8R,12S)-3,7-Dibenzyloxy-6-(cyclohexyldimethylsiloxy)-2,12-(isopropylidenedioxy)-1,5,5-trimethyl-9-methylene-6-(3-oxobutyl)bicyclo[6.4.0]dodecan-4-one

Cycloocta[de]-1,3-benzodioxin-8,10-diol,8-(3-butenyl)dodecahydro-2,2,9,9,11b-pentamethyl-6-methylene-7,11-bis(phenylmethoxy)-, (3aS,6aR,7S,8S,10R,11R,11aS,11bS)-

Cycloocta[de]-1,3-benzodioxin-8,10-diol,8-(3-butenyl)dodecahydro-2,2,9,9,11b-pentamethyl-6-methylene-7,11-bis(phenylmethoxy)-, (3aS,6aR,7S,8S,10R,11R,11aS,11bS)-

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紫杉醇

上游原料

(1R,2S,3S,5R,6S,7S,8S,9S)-2,6-Dibenzyloxy-3-(3-butenyl)-5-(tert-butyldimethylsiloxy)-7,9-(isopropylidenedioxy)-4,4,8-trimethyl-12-methylenebicyclo[6.4.0]dodecan-3-ol (4S,4aS,6R,11S,12S,12aR)-11,12-(Carbonyldioxy)-4a,8,13,13-tetramethyl-1-methylene-5-oxo-4-triethylsiloxy-1,2,3,4,4a,5,6,9,10,11,12,12a-dodecahydro-7,11-methanobenzocyclodecen-6-yl acetate 2-bromo-5-(triethylsilyloxy)pentene 1,2-O,O-Carbonyl-7,13-O,O-bis(triethylsilyl)-4-deacetyl-2-debenzoylbaccatin III (1S,2S,3S,6S,7S,8R,12S)-3,7-Dibenzyloxy-6-(cyclohexyldimethylsiloxy)-2,12-(isopropylidenedioxy)-1,5,5-trimethyl-9-methylene-6-(3-oxobutyl)bicyclo[6.4.0]dodecan-4-one (1S,2S,3R,4R,6S,7S,8R,12S)-3,7-Dibenzyloxy-6-(3-butenyl)-6-(cyclohexylmethylsiloxy)-2,12-(isopropylidenedioxy)-1,5,5-trimethyl-9-methylenebicyclo[6.4.0]dodecan-4-ol (1S,2S,3S,6S,7S,8R,12S)-3,7-Dibenzyloxy-6-(dicyclohexylmethylsiloxy)-2,12-(isopropylidenedioxy)-1,5,5-trimethyl-9-methylene-6-(3-oxobutyl)bicyclo[6.4.0]dodecan-4-one 4-[(1S,2S,3R,5R,6R,8S)-2,6-Dibenzyloxy-5-(tert-butyldimethylsiloxy)-3-(p-methoxybenzyloxy)-4,4,8-trimethyl-7-oxocyclooctyl]-4-pentenal (1S,2S,3R,4R,6S,7S,8R,12S)-3,7-Dibenzyloxy-6-(3-butenyl)-6-(tert-butyldimethylsiloxy)-2,12-(isopropylidenedioxy)-1,5,5-trimethyl-9-methylenebicyclo[6.4.0]dodecan-4-ol (4S,4aS,5S,6S,7R,8R,11S,12S,12aR)-6,12-Dibenzyloxy-11-(tert-butyldimethylsiloxy)-4,5-(isopropylidenedioxy)-4a,8,13,13-tetramethyl-1-methylenetetradecahydro-7,11-methanobenzocyclodecene-7,8-diol (4S,4aS,5S,6S,7R,8R,11S,12S,12aR)-11,12-(Carbonyldioxy)-4,5-(isopropylidenedioxy)-4a,8,13,13-tetramethyl-1-methylenetetradecahydro-7,11-methanobenzocyclodecene-5,7,8-triol (2S,4S,4aS,6R,9S,11S,12S,12aS)-2-Bromo-11,12-(carbonyldioxy)-4a,8,13,13-tetramethyl-1-methylene-5-oxo-4,9-bis(triethylsiloxy)-1,2,3,4,4a,5,6,9,10,11,12,12a-dodecahydro-7,11-methanobenzocyclodecen-6-yl acetate 7,13-二-O-(三乙基硅烷基)浆果赤霉素III (4S,4aS,6R,9S,11S,12S,12aR)-11,12-(Carbonyldioxy)-4a,8,13,13-tetramethyl-1-methylene-5-oxo-4,9-bis(triethylsiloxy)-1,2,3,4,4a,5,6,9,10,11,12,12a-dodecahydro-7,11-methanobenzocyclodecen-6-yl acetate (1S,2S,3S,4R,6R,7S,8R,12S)-3,7-Dibenzyloxy-4-(tert-butyldimethylsiloxy)-6-(p-methoxybenzyloxy)-1,5,5-trimethyl-9-methylenebicyclo[6.4.0]dodecane-2,12-diol (4S,4aS,6R,11S,12S,12aR)-11,12-(Carbonyldioxy)-4a,8,13,13-tetramethyl-1-methylene-5,9-dioxo-4-triethylsiloxy-1,2,3,4,4a,5,6,9,10,11,12,12a-dodecahydro-7,11-methanobenzocyclodecen-6-yl acetate (4S,4aS,5S,6S,7R,8R,11S,12S,12aR)-6,12-Dibenzyloxy-11-(cyclohexyldimethylsiloxy)-4,5-(isopropylidenedioxy)-4a,8,13,13-tetramethyl-1-methylenetetradecahydro-7,11-methanobenzocyclodecene-7,8-diol 紫杉醇 (4S,4aS,5S,6S,7R,8R,11S,12S,12aR)-11,12-(Carbonyldioxy)-7,8-dihydroxy-4,5-(isopropylidenedioxy)-4a,8,13,13-tetramethyl-1-methylenetetradecahydro-7,11-methanobenzocyclodecen-6-yl acetate (1S,2S,3S,6S,7S,8R,12S)-3,7-Dibenzyloxy-6-(3-butenyl)-6-(cyclohexylmethylsiloxy)-2,12-(isopropylidenedioxy)-1,5,5-trimethyl-9-methylenebicyclo[6.4.0]dodecan-4-one 4-bromopent-4-en-1-ol (1S,4aR,5S,6S,9R,10R,11S,12S,12aS)-1,12-(Isopropylidenedioxy)-9,12a,13,13-tetramethyl-4-methylenetetradecahydro-6,10-methanobenzocyclodecene-5,6,9,10,11-pentaol (1S,2S,3S,6S,7S,8R,12S)-3,7-Dibenzyloxy-6-(3-butenyl)-6-(dicyclohexylmethylsiloxy)-2,12-(isopropylidenedioxy)-1,5,5-trimethyl-9-methylenebicyclo[6.4.0]dodecan-4-one (1S,2S,3S,4R,6S,7S,8R,12S)-3,7-Dibenzyloxy-6-(3-butenyl)-4,6-(tert-butylmethylsilylenedioxy)-2,12-(isopropylidenedioxy)-1,5,5-trimethyl-9-methylenebicyclo[6.4.0]dodecane (4S,4aS,6R,7R,8R,11S,12S,12aR)-11,12-(Carbonyldioxy)-7,8-dihydroxy-4a,8,13,13-tetramethyl-1-methylene-5-oxo-4-triethylsiloxytetradecahydro-7,11-methanobenzocyclodecen-6-yl acetate (1S,2S,3R,4R,6S,7S,8R,12S)-3,7-Dibenzyloxy-6-(3-butenyl)-6-(dicyclohexylmethylsiloxy)-2,12-(isopropylidenedioxy)-1,5,5-trimethyl-9-methylenebicyclo[6.4.0]dodecan-4-ol (1S,2S,3S,4R,6S,7S,8R,12S)-3,7-Dibenzyloxy-6-(3-butenyl)-4,6-(dicyclohexylsilylenedioxy)-2,12-(isopropylidenedioxy)-1,5,5-trimethyl-9-methylenebicyclo[6.4.0]dodecane 7-O-(三乙基硅烷基)浆果赤霉素III 巴卡丁 III 三乙基氯硅烷 (4S,4aS,5S,6S,7R,8R,11S,12S,12aR)-6,12-Dibenzyloxy-11-(dicyclohexylmethylsiloxy)-4,5-(isopropylidenedioxy)-4a,8,13,13-tetramethyl-1-methylenetetradecahydro-7,11-methanobenzocyclodecene-7,8-diol (1R,2S,5R,6S,7S,8S,9S)-2,6-Dibenzyloxy-5-(tert-butyldimethylsiloxy)-7,9-(isopropylidenedioxy)-4,4,8-trimethyl-12-methylenebicyclo[6.4.0]dodecan-3-one (1S,2S,3S,4R,6R,7S,8R,12S)-3,7-Dibenzyloxy-4-(tert-butyldimethylsiloxy)-2,12-(isopropylidenedioxy)-6-(p-methoxybenzyloxy)-1,5,5-trimethyl-9-methylenebicyclo[6.4.0]dodecane (1S,2S,3S,6S,7S,8R,12S)-3,7-Dibenzyloxy-6-(tert-butyldimethylsiloxy)-2,12-(isopropylidenedioxy)-1,5,5-trimethyl-9-methylene-6-(3-oxobutyl)bicyclo[6.4.0]dodecan-4-one 2α,10β-dibenzyloxy-11β-(t-butyldimethylsiloxy)-7β-hydroxy-1α-(p-methoxybenzyloxy)-8β,15,15-trimethyl-4-methylene-trans-bicyclo[6.4.0]dodecan-9-one (4S,4aR,5S,6S,7R,8R,11S,12S,12aR)-11,12-(Carbonyldioxy)-5,7,8-trihydroxy-4a,8,13,13-tetramethyl-1-methylene-4-(triethylsiloxy)tetradecahydro-7,11-methanobenzocyclodecen-6-yl acetate (1S,2S,4S,4aS,6R,9S,11S,12S,12aR)-2-Bromo-11,12-(carbonyldioxy)-1-hydroxy-1-hydroxymethyl-4a,8,13,13-tetramethyl-5-oxo-4,9-bis(triethylsiloxy)-1,2,3,4,4a,5,6,9,10,11,12,12a-dodecahydro-7,11-methanobenzocyclodecen-6-yl acetate 1,2-O,O-Carbonyl-7,13-O,O-bis(triethylsilyl)-2-debenzoylbaccatin III (4S,4aS,6R,9S,11S,12S,12aS)-1-Bromomethyl-11,12-(carbonyldioxy)-4a,8,13,13-tetramethyl-5-oxo-4,9-bis(triethylsiloxy)-3,4,4a,5,6,9,10,11,12,12a-decahydro-7,11-methanobenzocyclodecen-6-yl acetate (1S,2S,3S,6S,7S,8R,12S)-3,7-Dibenzyloxy-6-(3-butenyl)-6-(tert-butyldimethylsiloxy)-2,12-(isopropylidenedioxy)-1,5,5-trimethyl-9-methylenebicyclo[6.4.0]dodecan-4-one (2R,3R,5R,6S,7S,8S)-2,6-Dibenzyloxy-3-(tert-butyldimethylsiloxy)-7-[1-(3-hydroxypropyl)vinyl]-5-(p-methoxybenzyloxy)-4,4,8-trimethylcyclooctanone (4S,4aS,6R,9S,11S,12S,12aR)-11,12-(Carbonyldioxy)-9-hydroxy-4a,8,13,13-tetramethyl-1-methylene-5-oxo-4-triethylsiloxy-1,2,3,4,4a,5,6,9,10,11,12,12a-dodecahydro-7,11-methanobenzocyclodecen-6-yl acetate 5-Ethyl (2R,3R)-2-benzyloxy-3-hydroxy-3-phenylpropanethioate 2’-carboxybenzoylpaclitaxel (2R,3R,5R,6S,7S,8S)-2,6-Dibenzyloxy-3-(tert-butyldimethylsiloxy)-5-(p-methoxybenzyloxy)-4,4,8-trimethyl-7-{1-[3-(triethylsiloxy)propyl]vinyl}cyclooctanone

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