化合物简介
Sacubitril (INN developmental code name AHU-377) is an antihypertensive drug used in combination with valsartan. The combination drug valsartan/sacubitril, known during trials as LCZ696 and marketed under the brand name Entresto, is a treatment for heart failure. It was approved under the FDA's priority review process for use in heart failure on July 7, 2015.
基本信息
中文名称
沙库巴曲
英文名称
Sacubitril
中文别名
沙库必曲、4-(((2S,4R)-1-([1,1\'-联苯]-4-基)-5-乙氧基-4-甲基-5-氧代丙烷-2-基)氨基)-4-氧代丁酸
英文别名
4-[[(2S,4R)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoic acid、AHU-377、4-(((2S,4R)-1-([1,1\'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic acid、ENTRESTO
CAS号
149709-62-6
分子式
C24H29NO5
分子量
411.491
精确质量
411.205
PSA
92.7
LOGP
4.2259
编号系统
MDL号
MFCD00920862
物化性质
可溶性
10 mM in DMSO
合成路线
上游原料
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