化合物简介
Emivirine (MKC-442) is a failed experimental agent for the treatment of HIV. It is a non-nucleoside reverse transcriptase inhibitor. While emivirine showed promising antiviral activity in vitro, it failed to show sufficient efficacy in human trials. However it is still notable as an early proof of concept, which led to the discovery of a number of related antiviral drugs.
基本信息
中文名称
1-(乙氧基甲基)-6-(苯基甲基)-5-丙-2-基嘧啶-2,4-二酮
英文名称
emivirine
中文别名
英文别名
I-EBU、1EtOMe6Bz5i-Pr-U、Emivirine、Emivirine [USAN:INN]、[14C]-Emivirine、1-(ethoxymethyl)-5-(1-methylethyl)-6-(phenylmethyl)pyrimidine-2,4(1H,3H)-dione、Mkc 442、Coactinon、1-ethoxymethyl-5-isopropyl-6-benzyluracil、6-benzyl-1-(ethoxymethyl)-5-isopropyl uracil、6-benzyl-1-(ethoxymethyl)-5-propan-2-ylpyrimidine-2,4-dione
CAS号
149950-60-7
分子式
C17H22N2O3
分子量
302.368
精确质量
302.163
PSA
64.09
LOGP
2.2448
编号系统
UNII
X87G8IX72O
安全信息
海关编码
2933990090
合成路线
