化合物简介
Retigabine (INN) or ezogabine (USAN) is an anticonvulsant used as an adjunctive treatment for partial epilepsies in treatment-experienced adult patients. The drug was developed by Valeant Pharmaceuticals and GlaxoSmithKline. It was approved by the European Medicines Agency under the trade name Trobalt on March 28, 2011, and by the United States Food and Drug Administration (FDA), under the trade name Potiga, on June 10, 2011.
基本信息
中文名称
瑞替加滨
英文名称
ezogabine
中文别名
2,4-二氯-7-对甲苯磺酰基-7H-吡咯并[2,3-D]嘧啶、2-氨基-4-(4-氟苄基氨基)-1-乙氧羰基氨基苯
英文别名
D-23129, Ezogabine, N-(2-Amino-4-(4-fluorobenzylamino)phenyl)carbamic acid ethyl ester、Retigabine
CAS号
150812-12-7
分子式
C16H18FN3O2
分子量
303.331
精确质量
303.138
PSA
76.38
LOGP
4.3156
编号系统
UNII
12G01I6BBU
物化性质
密度
1.307 g/cm3
沸点
430ºC at 760 mmHg
闪点
213.9ºC
折射率
1.655
蒸汽压
1.34E-07mmHg at 25°C
安全信息
信号词
Danger
危险性防范说明
P273; P301 + P310 + P330; P391; P501
危险性描述
H301; H410
危险标志
GHS06, GHS09
上游原料
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