西洛他唑

西洛他唑

CAS号：152044-53-6

英文名：(1R,5S,6S,7R,10S,14S,16S)-6,10-dihydroxy-5,7,9,9-tetramethyl-14-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-13,17-dioxabicyclo[14.1.0]heptadecane-8,12-dione

分子式：C26H39NO6S

分子量：493.656

上游原料

Methanesulfonic acid (R)-2-[(4R,5S)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-pent-4-enyl ester

Methanesulfonic acid (R)-2-[(4R,5S)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-pent-4-enyl ester

12,13-bismethylene-12,13-secoepothilone

12,13-bismethylene-12,13-secoepothilone

(2S)-methyl-5-{(2S,3R)-[3-methyl-4-(2-methyl-thiazol-4-yl)-(2S)-(triethyl-silanyloxy)-but-(3E)-enyl]-oxiranyl}-pentanal

(2S)-methyl-5-{(2S,3R)-[3-methyl-4-(2-methyl-thiazol-4-yl)-(2S)-(triethyl-silanyloxy)-but-(3E)-enyl]-oxiranyl}-pentanal

(4S)-4-(2-Methyl-3-oxo-pent-2-yl)-2,2-dimethyl-[1,3]dioxane

(4S)-4-(2-Methyl-3-oxo-pent-2-yl)-2,2-dimethyl-[1,3]dioxane

(5S)-5-hydroxy-4,4-dimethyloct-7en-3-one

(5S)-5-hydroxy-4,4-dimethyloct-7en-3-one

(3S)-3-(tert-butyl-dimethyl-silanyloxy)-4,4-dimethyl-5-oxo-heptanal

(3S)-3-(tert-butyl-dimethyl-silanyloxy)-4,4-dimethyl-5-oxo-heptanal

(4S,7R,8S,9S,16S,Z)-8-((tert-butyldimethylsilyl)oxy)-4-((4-methoxybenzyl)oxy)-5,5,7,9-tetramethyl-16-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)oxacyclohexadec-13-ene-2,6-dione

(4S,7R,8S,9S,16S,Z)-8-((tert-butyldimethylsilyl)oxy)-4-((4-methoxybenzyl)oxy)-5,5,7,9-tetramethyl-16-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)oxacyclohexadec-13-ene-2,6-dione

(1-{5-[(1R)-(tert-butyl-dimethyl-silanyloxy)-(5S)-methyl-6-(triisopropyl-silanyloxy)-hexyl]-4,(5R)-dihydro-isoxazol-3-yl}-ethyl)-phosphonic acid diethyl ester

(1-{5-[(1R)-(tert-butyl-dimethyl-silanyloxy)-(5S)-methyl-6-(triisopropyl-silanyloxy)-hexyl]-4,(5R)-dihydro-isoxazol-3-yl}-ethyl)-phosphonic acid diethyl ester

2-[(2R,3R,4S,5S)-4-(tert-Butyl-dimethyl-silanyloxy)-1,1,3,5-tetramethyl-2-triphenylsilanyloxy-dec-9-enyl]-[1,3]dithiane

2-[(2R,3R,4S,5S)-4-(tert-Butyl-dimethyl-silanyloxy)-1,1,3,5-tetramethyl-2-triphenylsilanyloxy-dec-9-enyl]-[1,3]dithiane

4-[(E)-3-hydroxy-2-methylhex-1-en-5-yn-1-yl]-2-methyl-1,3-thiazole

4-[(E)-3-hydroxy-2-methylhex-1-en-5-yn-1-yl]-2-methyl-1,3-thiazole

2,2-Dimethyl-3-oxopentanal

2,2-Dimethyl-3-oxopentanal

isopropyl (3S,5R,6R,7S,8S,12Z,15S,16E)-15-acetoxy-7-(benzyloxy)-5-((tert-butyldimethylsilyl)oxy)-3-hydroxy-4,4,6,8,16-pentamethyl-17-(2-methylthiazol-4-yl)heptadeca-12,16-dienoate

isopropyl (3S,5R,6R,7S,8S,12Z,15S,16E)-15-acetoxy-7-(benzyloxy)-5-((tert-butyldimethylsilyl)oxy)-3-hydroxy-4,4,6,8,16-pentamethyl-17-(2-methylthiazol-4-yl)heptadeca-12,16-dienoate

(3S,6R,7S,8S,12Z,15S,16E)-7-(benzyloxy)-3-((tert-butyldimethylsilyl)oxy)-15-hydroxy-4,4,6,8,16-pentamethyl-17-(2-methylthiazol-4-yl)-5-oxoheptadeca-12,16-dienoic acid

(3S,6R,7S,8S,12Z,15S,16E)-7-(benzyloxy)-3-((tert-butyldimethylsilyl)oxy)-15-hydroxy-4,4,6,8,16-pentamethyl-17-(2-methylthiazol-4-yl)-5-oxoheptadeca-12,16-dienoic acid

(2R,6S)-toluene-4-sulfonic acid 2-hydroxy-6-methyl-non-(7Z)-enyl ester

(2R,6S)-toluene-4-sulfonic acid 2-hydroxy-6-methyl-non-(7Z)-enyl ester

(2R,3S,10S,7Z,11E)-(tert-butyldimethylsilyloxy)-3,11-dimethyl-12-(2-methyl-1,3-thiazol-4-yl)dodeca-7,11-diene-1,2-diol

(2R,3S,10S,7Z,11E)-(tert-butyldimethylsilyloxy)-3,11-dimethyl-12-(2-methyl-1,3-thiazol-4-yl)dodeca-7,11-diene-1,2-diol

(3S,5R,6R,7S,8S)-phenyl 3,5,7-trihydroxy-4,4,6,8-tetramethyl-10-undecenoate

(3S,5R,6R,7S,8S)-phenyl 3,5,7-trihydroxy-4,4,6,8-tetramethyl-10-undecenoate

(3R,4R,5R)-ethyl 5-(benzyloxy)-3-((tert-butyldimethylsilyl)oxy)-2,2,4-trimethyl-6-oxohexanoate

(3R,4R,5R)-ethyl 5-(benzyloxy)-3-((tert-butyldimethylsilyl)oxy)-2,2,4-trimethyl-6-oxohexanoate

(3S,6R,7S,8S)-1,3,7-Trihydroxy-4,4,6,8-tetramethyl-12-tridecen-5-one

(3S,6R,7S,8S)-1,3,7-Trihydroxy-4,4,6,8-tetramethyl-12-tridecen-5-one

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上游原料

(2E)-2-Methyl-3-(2-methyl-1,3-thiazol-4-yl)acrylaldehyde (Z)-(4S,7R,8S,9S,16S)-4-(tert-Butyl-dimethyl-silanyloxy)-8-hydroxy-5,5,7,9-tetramethyl-16-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-oxacyclohexadec-13-ene-2,6-dione (2S,3S,4R,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-6-[1,3]dithian-2-yl-2,4,6-trimethyl-5-triphenylsilanyloxy-heptan-1-ol (4S,5S)-4-Hydroxy-5-methyl-tetrahydro-pyran-2-one (-)-(3S)-3-(tert-butyldimethylsilyl)oxy-4,4-dimethyl-5-oxoheptanoic acid 2-[(2R,3R,4S,5S)-4-(tert-Butyl-dimethyl-silanyloxy)-1,1,3,5-tetramethyl-2-triphenylsilanyloxy-dec-9-enyl]-[1,3]dithiane (1S,3S,7S,10R,11S,12S,16R)-3-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)-1-ethenyl]-11-hydroxy-7-(4-methoxybenzyloxy)-8,8,10,12-tetramethyl-4,17-dioxa-bicyclo[14.1.0]heptadecane-5,9-dione (3S,6R,7S,8S,12Z,15S,16E)-3,7-bis(tert-butyldimethylsilyloxy)-15-hydroxy-4,4,6,8,16-pentamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxo-heptadeca-12,16-dienoic acid (S)-2-(methoxymethoxy)-5-(trimethylsilyl)pent-4-ynal (3R,4R,5S)-3-(2-(1,3-dithian-2-yl)propan-2-yl)-5-((S)-1-(benzyloxy)propan-2-yl)-4,7,7,8,8-pentamethyl-1,1,1-triphenyl-2,6-dioxa-1,7-disilanonane (3R,4R,5S,6S)-6-((S)-1-(benzyloxy)propan-2-yl)-3-(iodomethyl)-2-methoxy-3,5-dimethyltetrahydro-2H-pyran-4-ol (2S)-1-((tetrahydro-2H-pyran-2-yl)oxy)-5-(trimethylsilyl)pent-4-yn-2-ol (1S)-1-[(E)-1-Methyl-2-(2-methyl-1,3-thiazol-4-yl)-1-ethenyl]-3-butenyl (3S,6R,7S,8S)-3,7-di-[tert-butyldimethylsilyloxy]-4,4,6,8-tetramethyl-5-oxo-12-tridecenoate (1S)-[(1E)-methyl-2-(2-methyl-1,3-thiazol-4-yl)ethynyl]-3-butenyl acetate (4S,7R,8S,9S,16S)-4,8-bis-(tert-butyldimethylsilanyloxy)-5,5,7,9-tetramethyl-16-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)-1-vinyl]-(13Z)-1-oxacyclohexadec-13-ene-2,6-dione (7S)-(tert-butyl-dimethyl-silanyloxy)-(11S)-hydroxy-8,8,(10R,12S)-tetramethyl-(3S)-[1-methyl-(2E)-(2-methyl-thiazol-4-yl)-vinyl]-4,17-dioxa-bicyclo[14.1.0]heptadecane-5,9-dione 2-甲基-1,3-噻唑-4-甲醛 (1R,3S,4S,5R,6R)-3-((S)-2-Benzyloxy-1-methyl-ethyl)-4,6-dimethyl-2-oxa-bicyclo[4.1.0]heptan-5-ol (4S,5S)-5-methyltetrahydro-2H-pyran-2,4-diol (6S,7S,8R,9R)-7-(tert-Butyl-dimethyl-silanyloxy)-10-[1,3]dithian-2-yl-6,8,10-trimethyl-9-triphenylsilanyloxy-undec-1-en-5-ol (1E,3S)-3-(tert-butyldimethylsilyloxy)-2-methyl-6-trimethylsilyl-1-(2-methyl-1,3-thiazol-4-yl)-1-hexen-5-yne (1E,3Z)-1-甲氧基-2-甲基-3-(三甲基硅氧基)-1,3-戊二烯 (2R,3E)-ethyl 2-hydroxy-3-methyl-4-(2-methyl-1,3-thiazol-4-yl)-3-butenoate (2R,3E)-2-(tert-butyldimethylsilyloxy)-3-methyl-4-(2-methyl-1,3-thiazol-4-yl)-3-butenal (4R,5S,6S)-6-((S)-2-Benzyloxy-1-methyl-ethyl)-2-methoxy-3,3,5-trimethyl-tetrahydro-pyran-4-ol (S)-1-((3aS,6R,7aS)-8,8-dimethyl-2,2-dioxidotetrahydro-3H-3a,6-methanobenzo[c]isothiazol-1(4H)-yl)-2-methylhept-6-en-1-one 2-甲基噻唑-4-甲酸乙酯 (2S,3S,4R,5R)-1-(benzyloxy)-6-(1,3-dithian-2-yl)-2,4,6-trimethyl-5-((triphenylsilyl)oxy)heptan-3-ol (4S,5S)-2-(4-methoxyphenyl)-5-methyl-4-((S)-pent-4-en-2-yl)-1,3-dioxane (S,E)-2-methyl-1-(2-methylthiazol-4-yl)hexa-1,5-dien-3-yl (3R,5R,6R,7S,8S)-7-((tert-butyldimethylsilyl)oxy)-3-hydroxy-4,4,6,8-tetramethyl-5-((triphenylsilyl)oxy)tridec-12-enoate (3S,6R,7S,8S)-(S,E)-2-methyl-1-(2-methylthiazol-4-yl)hexa-1,5-dien-3-yl 3-((tert-butyldimethylsilyl)oxy)-7-hydroxy-4,4,6,8-tetramethyl-5-oxotridec-12-enoate (3S)-2-methyl-1-(2-methyl-1,3-thiazol-4-yl)hexa-1,5-dien-3-ol methyl (S)-2-((1R,2S)-1,3-dihydroxy-2-methylpropyl)pent-4-enoate (2S)-2-methylhept-6-en-1-ol (3S)-3-(methoxymethoxy)-6-(trimethylsilyl)hex-5-yn-2-ol 埃博霉素C [(S)-4-Methoxymethoxy-5-(tetrahydro-pyran-2-yloxy)-pent-1-ynyl]-trimethyl-silane (2R,3R,4R,5R)-3-((tert-butyldimethylsilyl)oxy)-6-(1,3-dithian-2-yl)-2,4,6-trimethyl-5-((triphenylsilyl)oxy)heptanal (2S,3S,4R)-2-((S)-1-(benzyloxy)propan-2-yl)-3,5-dimethyl-3,4-dihydro-2H-pyran-4-ol (1E,3S,5Z)-2-methyl-6-trimethylsilyl-1-(2-methyl-1,3-thiazol-4-yl)-1,5-hexadien-3-ol (2R,3E)-ethyl 2-(tert-butyldimethylsilyloxy)-3-methyl-4-(2-methyl-1,3-thiazol-4-yl)-3-butenoate Carbonic acid (E)-(R)-2-(tert-butyl-dimethyl-silanyloxy)-3-methyl-4-(2-methyl-thiazol-4-yl)-1-trimethylsilanylethynyl-but-3-enyl ester methyl ester (2R,3E)-2-hydroxy-3-methyl-4-(2-methyl-1,3-thiazol-4-yl)-3-butenenitrile [(4R,5R,6S)-6-((S)-2-Benzyloxy-1-methyl-ethyl)-2-methoxy-3,3,5-trimethyl-tetrahydro-pyran-4-yloxy]-triphenyl-silane (S)-2-Methoxymethoxy-5-trimethylsilanyl-pent-4-yn-1-ol

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