百科

甲砜霉素

CAS号：15318-45-3

英文名：thiamphenicol

分子式

C12H15Cl2NO5S

熔点

163-166ºC

密度

1.491g/cm3

分子量

356.222

沸点

695.9ºC at 760mmHg

溶解度

信号词

危险品标志

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化合物简介

Thiamphenicol is an antibiotic. Thiamphenicol is the methyl-sulfonyl analogue of chloramphenicol and has a similar spectrum of activity, but is 2.5 to 5 times as potent. Thiamphenicol is used particularly for the treatment of sexually transmitted infections and pelvic inflammatory disease.

基本信息

中文名称

甲砜霉素

英文名称

thiamphenicol

中文别名

甲砜氯霉素

英文别名

Neomyson、2,2-Dichloro-N-[(1R,2R)-1,3-dihydroxy-1-[4-(methylsulfonyl)phenyl]-2-propyl]acetamide、thiocymetin、D-Thiophenicol、Dextrosulphenidol、Thiamphenicol、ThiaMphenicol、8065c.b.、win-5063-2、THIAMPHENICHOL、D-Thiocymetin、thiophenicol

CAS号

15318-45-3

分子式

C12H15Cl2NO5S

分子量

356.222

精确质量

355.005

PSA

112.08

LOGP

1.876

编号系统

PubChem号

24899874

RTECS号

AB6680000

BRN号

2819542

MDL号

MFCD00467983

EINECS号

239-355-3

物化性质

外观与性状

灰白色固体

密度

1.491g/cm3

沸点

695.9ºC at 760mmHg

熔点

163-166ºC

闪点

374.7ºC

折射率

1.589

稳定性

Stable at normal temperatures and pressures.

安全信息

安全说明

S22; S24/25

海关编码

2941400000

生产方法及用途

用途

甲砜霉素为一氯霉素类广谱抗菌素，用于敏感菌如流感嗜血杆菌、大肠埃希菌、沙门菌属等所致的呼吸道、尿路、肠道等感染。

合成路线

895570-99-7

(2R,3R)-2-benzylamino-3-(4-methylsulfonylphenyl)-propane-1,3-diol

海关数据

国家/地区名称	海关编码	更新时间	操作
中国	2924299090	2019-03	查看
美国	2924297690	2019-03	查看
印度	29242990	2019-03	查看
欧盟	29242998	2019-03	查看
英国	2924299899	2019-03	查看
日本	292429090	2019-03	查看
韩国	2924299090	2019-03	查看
加拿大	2924290030	2019-03	查看

上游原料

共找到33个上游原料 >

160751-25-7

(SS)-(-)-N-(p-methylthiobenzylidene)-p-toluenesulfinamide

160751-27-9

(2S,3S)-2-hydroxymethyl-3-(4-methylthiophenyl)-1H-aziridine

108656-29-7

(4S,5R)-N-(2,3-dimethylbenzoyl)-4-fluoromethyl-5-<4-(methylsulphonyl)phenyl>-2-oxazolidinone

914646-16-5

(S)-1-[4-(methylsulfonyl)phenyl]-2-propen-1-ol

160751-26-8

cis-(SS,2S,3S)-(+)-N-(p-toluenesulfinyl)-2-carbomethoxy-3-(p-methylthiophenyl)aziridine

1424361-00-1

(1S,2R,5S,8R,1'R)-5-(1'-hydroxy(p-methylsulfonyl)benzyl)-8,11,11-trimethyl-3-oxa-6-azatricyclo[6.2.1.02,7]undec-6-en-4-one

上游原料

(SS)-(-)-N-(p-methylthiobenzylidene)-p-toluenesulfinamide (2S,3S)-2-hydroxymethyl-3-(4-methylthiophenyl)-1H-aziridine (4S,5R)-N-(2,3-dimethylbenzoyl)-4-fluoromethyl-5-<4-(methylsulphonyl)phenyl>-2-oxazolidinone (S)-1-[4-(methylsulfonyl)phenyl]-2-propen-1-ol cis-(SS,2S,3S)-(+)-N-(p-toluenesulfinyl)-2-carbomethoxy-3-(p-methylthiophenyl)aziridine (1S,2R,5S,8R,1'R)-5-(1'-hydroxy(p-methylsulfonyl)benzyl)-8,11,11-trimethyl-3-oxa-6-azatricyclo[6.2.1.02,7]undec-6-en-4-one 4-(甲基巯基)苯甲醛 1-[4-(methylsulfonyl)phenyl]-2-propen-1-ol syn-(2R,3R)-[2-amino-3-methoxy-3-(4-methanesulfonyl-phenyl)-1-propanol] N-[3-hydroxy-1-(4-methylsulfanylphenyl)-1-oxopropan-2-yl]acetamide dichloroacetyl-phosphorous acid diethyl ester 1-[4-(methylsulfanyl)phenyl]-2-propen-1-ol 甲基碘 (2S,3R)-methyl-2-amino-3-[4-(methylsulfonyl)phenyl]-3-hydroxy-propanoate (1RS,2RS)-2-acetylamino-1-(4-methylsulfanyl-phenyl)-propane-1,3-diol [R(r*,r*]-2-氨基-1-[p-(甲基磺酰基)苯基]-1,3-丙二醇 (4R,5R)-4-hydroxymethyl-5-(4-(methylsulphonyl)phenyl)-2-oxazolidinone (4R,5R)-4-hydroxymethyl-5-<4-(methylthio)phenyl>-2-oxazolidinone [R(R*,R*)]-2-氨基-1-[4-(甲硫基)苯基]丙烷-1,3-二醇 (2R,3R)-2-benzylamino-3-(4-methylsulfonylphenyl)-propane-1,3-diol (1R,2R)-2-(2,2-dichloro-acetylamino)-1-(4-methylsulfanyl-phenyl)-propane-1,3-diol 五氯丙酮 D-(-)-threo-1-(4-methylthiophenyl)-2-amino-1,3-propanediol 4-[(1R,2R)-2-(2,2-dichloro-acetylamino)-1,3-dihydroxy-propyl]-benzenesulfinic acid (1R,2R)-2-ethoxycarbonylamino-1-<4-(methylthio)phenyl>-1,3-propanediol 对甲砜基苯甲醛二氯乙酸乙酯 (1R,2S)-2-(2,3-dimethylbenzoyl)amino-3-fluoro-1-<4-(methylsulphonyl)phenyl>-1-propanol 二氯乙酸甲酯 (S)-1-[4-(methylsulfonyl)phenyl]allyl carbamate (4S,5R)-4-fluoromethyl-5-<4-(methylsulphonyl)phenyl>-2-oxazolidinone (1R,2R)-2-ethoxycarbonylamino-1-<4-(methylsulphonyl)phenyl>-1,3-propanediol