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Clasto-lactacystin (Omuralide)

Clasto-lactacystin (Omuralide)

CAS号:154226-60-5
英文名:CLASTO-LACTACYSTIN β-LACTONE
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化合物简介
A cell permeable, irreversible proteasome inhibitor. It is 20-fold more potent than Lactacystin. Lactacytstin spontaneously converts to clasto-lactacystin in biological systems. Clasto-lactacystin is the only cell permeable form of lactacystin. Induces neurite growth and inhibits cell cycle progression similar to lactacytin.
基本信息
上游原料
methyl (2S,3S,4R)-3-((tert-butyldimethylsilyl)oxy)-2-formyl-1-(4-methoxybenzyl)-4-methyl-5-oxopyrrolidine-2-carboxylate (5R,3R)-5-hydroxymethyl-1-(4-methoxybenzyl)-3-methyl-3-methylsulfanyl-2,4-dioxo-pyrrolidine-5-carboxylic acid methyl ester (5R,4S,3R)-4-hydroxy-5-hydroxymethyl-1-(4-methoxybenzyl)-3-methyl-3-methylsulfanyl-2-oxo-pyrrolidine-5-carboxylic acid methyl ester (2R,3S)-(para-bromophenyl)-2-benzylcarbamate-3-hydroxy-4-methylpentanoate N-Benzyloxycarbonyl-DL-threo-β-hydroxyleucin-methylester (3R,4S,5R,1'S)-4-acetoxy-5-(1'-acetoxy-2'-methylpropyl)-5-hydroxymethyl-3-methylpyrrolidin-2-one (2R,3S)-methyl 3-((4S,5S)-3-benzyl-4-(((tert-butyldimethylsilyl)oxy)methyl)-5-isopropyloxazolidin-4-yl)-3-hydroxy-2-methylpropanoate methyl (4S,5S)-4-(hydroxymethyl)-5-isopropyl-2-phenyl-4,5-dihydrooxazole-4-carboxylate methyl (2R,3S,4R)-3-hydroxy-2-((S)-1-hydroxy-2-methylpropyl)-1-(4-methoxybenzyl)-4-methyl-5-oxopyrrolidine-2-carboxylate methyl (2S,3S,4R)-2-((S)-1-acetoxy-2-methylpropyl)-3-hydroxy-4-methyl-5-oxopyrrolidine-2-carboxylate (2R,4S,5R)-(-)-5-azido-4-isopropyl-2-phenyl[1,3]dioxane 3-(5S-isopropyl-4S-methoxycarbonyl-2-phenyl-4,5-dihydro-oxazol-4-yl)-3S-hydroxy-2R-methyl-N,N-diethylpropionamide (2R,3S)-(-)-2-azido-4-methyl-1-pentane-1,3-diol (2R,3S)-1-tert-butyl 2-methyl 2-((S)-1-acetoxy-2-methylpropyl)-3-hydroxy-5-oxopyrrolidine-1,2-dicarboxylate (2S,3S)-2-bromo-4-methyl-3-benzoyloxypentanoic acid methyl ester (3R,4S,5R,6S)-1-氮杂-4-羟基-5-羟基甲基-6-异丙基-3-甲基-7-氧杂双环[3.3.0]辛烷-2-酮 (3R,4S)-1-tert-butoxycarbonyl-4-hydroxy-3,8,8-trimethyl-2-oxo-1-aza-7,9-dioxaspiro[4,5]decane (2R,3S)-3-hydroxy-3-((4S,5S)-5-isopropyl-4-(methoxycarbonyl)-2-phenyl-4,5-dihydrooxazol-4-yl)-2-methylpropanoic acid 1-tert-butyl 2-ethyl (2S)-2-[(1S)-1-(acetyloxy)-2-methylpropyl]-5-oxo-2,5-dihydro-1H-pyrrole-1,2-dicarboxylate 1-tert-butyl 2-ethyl (2S)-2-[(1S)-1-(acetyloxy)-2-methylpropyl]-5-oxopyrrolidine-1,2-dicarboxylate tert-butyl (5-((1S,2S)-1-hydroxy-2-methylbut-3-en-1-yl)-2,2-dimethyl-1,3-dioxan-5-yl)carbamate ethyl (1S)-1-[(tert-butoxycarbonyl)amino]-2-isopropylcyclopent-2-ene-1-carboxylate methyl (2R,3S,4R)-3-((tert-butyldimethylsilyl)oxy)-2-((S)-1-hydroxy-2-methylallyl)-1-(4-methoxybenzyl)-4-methyl-5-oxopyrrolidine-2-carboxylate (1S)-N-(1-cyano-2-isopropylcyclopent-2-en-1-yl)-P,P-diphenylphosphinic amide (1R,4R,5S)-1-((S)-1-hydroxy-2-methylpropyl)-2-(4-methoxybenzyl)-4-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione (5R,4R,3R)-4-(tert-butyl-dimethyl-silanyloxymethyl)-5-hydroxymethyl-1-(4-methoxybenzyl)-3-methyl-3-methylsulfanyl-2-oxo-pyrrolidine-5-carboxylic acid methyl ester methyl (4S,5S)-4-((1S,2S,E)-1-hydroxy-6-methoxy-2-methyl-6-oxohex-3-en-1-yl)-5-isopropyl-2-phenyl-4,5-dihydrooxazole-4-carboxylate (4R,5S)-5-isopropyl-2-phenyl-4,5-dihydrooxazole-4-carboxylic acid methyl ester (2R)-2-Amino-3-hydroxy-4-methylpentansaeure-methylester methyl (2R,3R,4R)-3-hydroxy-1-(4-methoxybenzyl)-4-methyl-4-(methylthio)-5-oxo-2-((pivaloyloxy)methyl)pyrrolidine-2-carboxylate (3R,4S,5R,1'S)-4-acetoxy-5-(1'-acetoxy-2'-methylpropyl)-3-methylpyrrolidin-2-one-5-carboxylic acid methyl (4R,5S)-4-formyl-5-isopropyl-2-phenyl-4,5-dihydrooxazole-4-carboxylate (para-bromophenyl)-4-methyl-2-(E)-pentenoate L-threo-Pentitol, 3,4-anhydro-1,2-dideoxy-2-methyl- 1-tert-butyl 2-ethyl (2S,3S,4R)-2-[(1S)-1-(acetyloxy)-2-methylpropyl]-3-hydroxy-4-methyl-5-oxopyrrolidine-1,2-dicarboxylate (2R,3R,4R,1'S)-(+)-3-hydroxy-2-(1-hydroxy-2-methyl-propyl)-4-methyl-5-oxo-pyrrolidine-2-carboxylic acid methyl ester methyl (2E)-4-methylpent-2-enoate (3R,4s,5r)-4-羟基-5-[(1s)-1-羟基-2-甲基丙基]-3-甲基-2-吡咯烷酮-5-羧酸 (2R,3S)-2-azo-4-methyl-3-benzoyloxypentanoic acid methyl ester 1-(tert-butyl) 2-methyl (2S,3S,4R)-2-((S)-1-acetoxy-2-methylpropyl)-3-hydroxy-4-methyl-5-oxopyrrolidine-1,2-dicarboxylate (3R,4S,5S,6S)-1-氮杂-5-(t-丁基二甲基硅烷基氧基甲基)-4-羟基-6-异丙基-3-甲基-7-氧杂双环[3.3.0]-辛烷-2-酮 methyl (2R,3R,4R)-3-((tert-butyldimethylsilyl)oxy)-1-(4-methoxybenzyl)-4-methyl-4-(methylthio)-5-oxo-2-((pivaloyloxy)methyl)pyrrolidine-2-carboxylate methyl (4S,5S)-4-((1S,2S)-1-hydroxy-2-methylbut-3-en-1-yl)-5-isopropyl-2-phenyl-4,5-dihydrooxazole-4-carboxylate methyl (4R)-1-(4-methoxybenzyl)-4-methyl-4-(methylthio)-3,5-dioxopyrrolidine-2-carboxylate (2R,3S)-2,3-dihydroxy-4-methylpentanoic acid methyl ester methyl (2R,3S,4R)-3-((tert-butyldimethylsilyl)oxy)-2-((S)-1-hydroxy-2-methylpropyl)-1-(4-methoxybenzyl)-4-methyl-5-oxopyrrolidine-2-carboxylate 1-tert-butyl 2-ethyl (2S,3S)-2-[(1S)-1-(acetyloxy)-2-methylpropyl]-3-hydroxy-5-oxopyrrolidine-1,2-dicarboxylate ethyl 2-((1S)-1-hydroxy-2-methylpropyl)-5-oxo-D-prolinate tert-butyl (3R,4S)-2,4-dihydroxy-3,8,8-trimethyl-7,9-dioxa-1-azaspiro[4.5]decane-1-carboxylate