化合物简介
Ioflupane (123I) is the International Nonproprietary Name of a phenyltropane compound which is a neuro-imaging radiopharmaceutical drug, used by nuclear medicine physicians for the diagnosis of Parkinson's disease and the differential diagnosis of Parkinson's disease over other disorders presenting similar symptoms. It is injected into a patient and viewed with a gamma camera in order to acquire SPECT images of the brain with particular respect to the striatum, a subcortical region of the basal ganglia. The drug is sold under the tradename DaTSCAN and is manufactured by GE Healthcare, formerly Amersham plc. It is not marketed outside of Europe and the United States.
基本信息
中文名称
(1R,2S,3S)-8-(3-氟丙基)-3-(4-碘苯基)-8-氮杂双环[3.2.1]辛烷-2-羧酸甲酯
英文名称
methyl (3S,4S,5R)-8-(3-fluoropropyl)-3-(4-iodophenyl)-8-azabicyclo[3.2.1]octane-4-carboxylate
中文别名
英文别名
(123I)FP-Cit、FP-Cit、2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane、8-Azabicyclo(3.2.1)octane-2-carboxylic acid,8-(3-fluoropropyl)-3-(4-iodophenyl)-,methyl ester,(1R-(exo,exo))
CAS号
155797-99-2
分子式
C18H23FINO2
分子量
431.284
精确质量
431.076
PSA
29.54
LOGP
3.6982
物化性质
外观与性状
无色或淡黄色晶体
密度
1.45g/cm3
沸点
446.7ºC at 760mmHg
闪点
224ºC
折射率
1.561
蒸汽压
3.57E-08mmHg at 25°C
合成路线